Piroheptine
- Product Name
- Piroheptine
- CAS No.
- 16378-22-6
- Chemical Name
- Piroheptine
- Synonyms
- Trimol;Piroheptine HCl;piroheptine hydrochloride;Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI)
- CBNumber
- CB71179537
- Molecular Formula
- C22H25N.ClH
- Formula Weight
- 339.907
- MOL File
- 16378-22-6.mol
Piroheptine Property
- Melting point:
- 250-253°
Safety
- Toxicity
- LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi)
N-Bromosuccinimide Price
- Product number
- API0003877
- Product name
- PIROHEPTINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.6
- Updated
- 2021/12/16
- Product number
- SYN5526
- Product name
- PiroheptineHydrochloride
- Packaging
- 50mg
- Price
- $1301
- Updated
- 2021/12/16
Piroheptine Chemical Properties,Usage,Production
Uses
Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1].
Definition
ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+).
in vivo
Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model[1].
| Animal Model: | Male 8-week-old C57BL/6J mice (20-30 g)[1] |
| Dosage: | 20 mg/kg |
| Administration: | IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval) |
| Result: | Prevented loss of striatal dopamine. |
References
[1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2
Piroheptine Preparation Products And Raw materials
Raw materials
Preparation Products
Piroheptine Suppliers
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