4-Fluorophthalic acid
- Product Name
- 4-Fluorophthalic acid
- CAS No.
- 320-97-8
- Chemical Name
- 4-Fluorophthalic acid
- Synonyms
- RARECHEM AL BO 0829;4-fluorophthalicaci;4-FLUOROPHTHALIC ACID;4-fluorobenzene-1,2-dioic acid;320-97-8;4-Fluorobenzene-1,2-dicarboxylic acid;1,2-Benzenedicarboxylic acid, 4-fluoro-
- CBNumber
- CB1317369
- Molecular Formula
- C8H5FO4
- Formula Weight
- 184.12
- MOL File
- 320-97-8.mol
4-Fluorophthalic acid Property
- Melting point:
- 154-158℃
- Boiling point:
- 377.2±27.0 °C(Predicted)
- Density
- 1.551±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 2.91±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Insoluble in water.
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H5FO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,(H,10,11)(H,12,13)
- InChIKey
- OMCXTFVBNCFZMY-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=CC=C(F)C=C1C(O)=O
- CAS DataBase Reference
- 320-97-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F621483
- Product name
- 4-FluorophthalicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- F621483
- Product name
- 4-FluorophthalicAcid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2621-3-14
- Product name
- 4-Fluorophthalic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J52643
- Product name
- 4-Fluorophthalicacid
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- X4506
- Product name
- 4-Fluorophthalicacid
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
4-Fluorophthalic acid Chemical Properties,Usage,Production
Uses
4-Fluorophthalic acid is used as a pharmaceutical intermediate.
Synthesis
452-64-2
320-97-8
Preparation of B: 4-fluoro-1,2-dimethylbenzene A (50.0 g, 402.7 mmol) was dissolved in 150 mL of water/tert-butanol (70/30, v/v) mixed solvent with an excess of KMnO4 (400 g, 2.54 mol). After the reaction mixture was refluxed overnight, EtOH (900 mL) was added to quench the unreacted KMnO4, followed by distillation to remove the alcohol. The resulting brown suspension was filtered through a diatomaceous earth pad and the filtrate was concentrated and acidified with concentrated HCl. The product was collected by filtration, the aqueous phase was extracted with EtOAc and the organic phase was dried with Na2SO4. After evaporation of the solvent under reduced pressure, a white solid B (70.0 g, 94% yield) was obtained.1H-NMR (400 MHz, DMSO-d6): δ 7.39 (m, 1H), 7.63 (br s, 1H), 7.99 (br s, 1H).
References
[1] Patent: WO2008/151211, 2008, A1. Location in patent: Page/Page column 54
[2] Australian Journal of Chemistry, 1976, vol. 29, p. 2571 - 2581
4-Fluorophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorophthalic acid manufacturers
- Product
- 4-fluorophthalic acid 320-97-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- 4-Fluorophthalic acid 320-97-8
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17
- Product
- 4-Fluorophthalic acid 320-97-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04