5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE
- Product Name
- 5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE
- CAS No.
- 57473-32-2
- Chemical Name
- 5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE
- Synonyms
- Zinc04204219;5,7-Dichloroimidazo[1,2-α]pyrimidine;5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE;Imidazo[1,2-a]pyrimidine, 5,7-dichloro-;5,7-Dichloroimidazo[1,2-a]pyrimidine hydrochloride salt
- CBNumber
- CB1326754
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 57473-32-2.mol
5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE Property
- Melting point:
- 257-259°C
- Density
- 1.69
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO, Methanol
- pka
- 2.31±0.30(Predicted)
- form
- Solid
- color
- Light Yellow
- CAS DataBase Reference
- 57473-32-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D434840
- Product name
- 5,7-Dichloroimidazo[1,2-a]pyrimidine
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 009198
- Product name
- 5,7-Dichloroimidazo[1,2-a]pyrimidine
- Packaging
- 100mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- FD21677
- Product name
- 5,7-Dichloroimidazo[1,2-a]pyrimidine
- Packaging
- 250mg
- Price
- $575
- Updated
- 2021/12/16
- Product number
- HCH0024258
- Product name
- 5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- 9277
- Product name
- 5,7-Dichloroimidazo[1,2-α]pyrimidine
- Packaging
- 100mg
- Price
- $875
- Updated
- 2021/12/16
5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Solid
Synthesis
51647-90-6
57473-32-2
General procedure for the synthesis of 5,7-dichloroimidazo[1,2-a]pyrimidines from 5,7-dihydroimidazo[1,2-A]pyrimidines: imidazo[1,2-a]pyrimidine-5,7-diol (4 g, 26.49 mmol) was dissolved in phosphorus trichloride (POCl3, 50 mL) and heated to a temperature of 90 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove excess POCl3. The residue was quenched with saturated sodium bicarbonate (NaHCO3) solution (100 mL) and subsequently extracted with ethyl acetate (EtOAc, 2 x 60 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target compound 5,7-dichloroimidazo[1,2-a]pyrimidine (3.5 g, 71% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.07 (d, J=1.6Hz, 1H), 7.86 (d, J=1.6Hz, 1H), 7.69 (s, 1H); LCMS (mass spectrometry) analysis showed molecular ion peaks m/z: 187.9 ([M+H]+).
References
[1] Patent: WO2018/48930, 2018, A1. Location in patent: Paragraph 00337
[2] Patent: EP1666468, 2006, A1. Location in patent: Page/Page column 64
5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE Suppliers
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View Lastest Price from 5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE manufacturers
- Product
- 5,7-Dichloroimidazo[1,2-a]pyrimidine 57473-32-2
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 5,7-DICHLORO-IMIDAZO[1,2-A]PYRIMIDINE 57473-32-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 5,7-DichloroiMidazo[1,2-a]pyriMidine 57473-32-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15