Discovery Structure Gene, mRNA, and precursor Receptors Agonists and Antagonists Biological functions Clinical implications
ChemicalBook > CAS DataBase List > NEUROMEDIN B

NEUROMEDIN B

Discovery Structure Gene, mRNA, and precursor Receptors Agonists and Antagonists Biological functions Clinical implications
Product Name
NEUROMEDIN B
CAS No.
87096-84-2
Chemical Name
NEUROMEDIN B
Synonyms
NMB;NEUROMEDIN B;GNLWATGHFM-NH2;Pig neuromedin B;NEUROMEDIN B ≥90%;Porcine neuromedin B;NEUROMEDIN BNEUROMED;Neuromedin B (porcin;NEUROMEDIN B, PORCINE;Neuromedin B, ≥90% (HPLC)
CBNumber
CB1328763
Molecular Formula
C52H73N15O12S
Formula Weight
1132.29
MOL File
87096-84-2.mol
More
Less

NEUROMEDIN B Property

Boiling point:
1697.4±65.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O : 12.5 mg/mL (11.04 mM; Need ultrasonic)
form 
Solid
pka
13.16±0.46(Predicted)
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N3762
Product name
Neuromedin B
Purity
≥90% (HPLC)
Packaging
1mg
Price
$309
Updated
2024/03/01
Alfa Aesar
Product number
J66286
Product name
Neuromedin B
Packaging
1mg
Price
$105
Updated
2023/06/20
Tocris
Product number
1908
Product name
NeuromedinB(porcine)
Packaging
1
Price
$149
Updated
2021/12/16
TRC
Product number
N391003
Product name
NeuromedinB,Porcine
Packaging
1mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
N2171-76
Product name
Neuromedin B
Packaging
1mg
Price
$531
Updated
2021/12/16
More
Less

NEUROMEDIN B Chemical Properties,Usage,Production

Discovery

NMB was purified from the porcine spinal cord in 1983 as one of the peptides with a stimulant effect on rat uterus contraction. NMB is structurally related to ranatensin, an amphibian peptide belonging to the bombesin-like peptide family, which was purified in 1970 by Nakajima. NMB cDNA was first isolated in the human and then in the rat.

Structure

NMB was first identified as a decapeptide, but subsequently 30 (NMB-30) or 32 (NMB-32) forms were also identified. The decapeptide (NMB) is also noted as NMB23–32. The C-terminal residue of the peptide is amidated. The amino acid sequences for the pig, human, and rat NMB-32 are highly conserved, and only differ in 4 aa. Their sequences of 11 aa from the C-terminus are completely identical.

Gene, mRNA, and precursor

Human NMB is located on chromosome 15 (15q25.2) and consists of three exons. Human NMB is encoded in a 76-aa precursor protein (preproNMB), which consists of a 24-aa signal peptide, a 32-aa mature peptide (NMB-32), and a 17-aa C-terminal extended peptide. The C-terminus of NMB-32 is flanked by a Gly-Lys-Lys sequence, which is a target for proteolytic processing. Nmb in rats consists of three exons, and the intron-exon border is well conserved in humans and rats. Rat preproNMB is 117 aa long, and its structure is similar to that of human preproNMB. The difference exists in the length of the extended peptide, which is 52 aa long instead of 17 aa, and the existence of a cleavage recognition site at the C-terminus of the extended peptide.

Receptors

NMB binds the NMB-preferring receptor (NMBR, also called BB1) with high affinity (Ki = 4 nM for rat NMBR-transfected BALB3T3 cells), and also binds the gastrin-releasing peptide-preferring receptor with much lower affinity (Ki = 174 nM for mouse GRPRtransfected BALB3T3 cells). NMBR is a GPCR with seven-transmembrane domains. The TM5 segment is shown to be critical for high affinity and selectivity for agonist binding. NMBR has been cloned in humans, rats,mice, chicks, and frogs. Both human and rat NMBR cDNAs encode a 390-aa residue protein, and the calculated Mr is 43 kDa in rats. The sequence similarity of the NMBR genes in mice, rats, and humans is 90%–97%. In rats, Nmbr mRNA is detected notably in the olfactory regions, hippocampal formations, amygdala, thalamus, and central core, and moderate expression is found in many other brain regions. In the peripheral organs, strong expression is found in the rat and mouse esophagus, and significant levels of expression have been found by RT-PCR in the intestines, testis, and uterus in mice.

Agonists and Antagonists

NMB is a naturally occurring agonist for NMBR. GRP and NMC are naturally occurring agonists with lower affinity for NMBR than GRPR. Labeled bombesin (BN) analogs are useful for tumor imaging and BN receptor mediated cytotoxicity.  PD168368 and PD176252 are antagonists with high selectivity for the human NMBR.

Biological functions

NMB regulates smooth muscle contraction, exocrine and endocrine secretions, body temperature, food intake, energy homeostasis, grooming and scratching (itch perception), nociception, anxiety, sighing, locomotion, and cell growth. The contractile effect of NMB is found to be more potent than that of GRP in the rat urinary bladder and esophagus.

Clinical implications

NMBR is expressed in various human cancers, including small cell lung carcinoma, nonsmall cell lung carcinoma, colon cancer, and various carcinoid tumors, and NMB may have a growth effect. Because NMB has a regulatory function for TSH release, NMB could be implicated in human thyroid disorders.

Description

NMB is distributed in the central nervous system as well as the gastrointestinal tract, and has many regulatory functions in physiology such as exocrine and endocrine secretions, smooth muscle contraction, feeding, energy homeostasis, body temperature, nociception, itch perception, anxiety, sighing, and cell growth.

Uses

Neuromedin B, porcine is an endogenous activator for the NMBR (neuromedin B receptor).

General Description

Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.

Biochem/physiol Actions

Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.

storage

Store at -20°C

NEUROMEDIN B Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

NEUROMEDIN B Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9947
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29796
Advantage
68
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5503
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9962
Advantage
55
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9292
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6527
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10523
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
999
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
Nanjing chengqimei Biotechnology Co., Ltd
Tel
19850819832
Email
2173594524@qq.com
Country
China
ProdList
2638
Advantage
58
Nanchang Tianzhen Biotechnology Co., Ltd
Tel
13173652190
Email
pomy@tanzhenbio.com
Country
China
ProdList
1619
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14092
Advantage
58
Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
ProdList
3189
Advantage
58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921 13355716090
Email
Sales@gotopbio.com
Country
China
ProdList
2836
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10011
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
Country
China
ProdList
24998
Advantage
58
Shangqiu Ladybug Network Technology Co., LTD
Tel
0370-2059268 15672839268
Fax
03702782809
Email
2352713635@qq.com
Country
China
ProdList
4206
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Email
alan.chow@synzest.com
Country
China
ProdList
9471
Advantage
58
Nanjing Yuanpeptide Biotech Co.,Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2977
Advantage
58
Chengdu Jinglin Biotechnology Co., Ltd.
Tel
17711399154
Email
3211919385@qq.com
Country
China
ProdList
1815
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
Country
China
ProdList
5144
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24017
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6213
Advantage
58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Tel
0571-85350119 15888826472
Email
15888826472@163.com
Country
China
ProdList
2729
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4590
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
18014456767 18014456767
Email
wenxi@jszkhy.com
Country
China
ProdList
1349
Advantage
58
Combio (Suzhou) Ltd.
Tel
0512-51886999 17706251929
Email
office@combiosz.com
Country
China
ProdList
2224
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29990
Advantage
58
Shanghai Toyang Biotechnology Co., LTD
Tel
021-59555769 13524932310
Fax
021-50342869
Email
1405894150@qq.com
Country
China
ProdList
8221
Advantage
58
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091 13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
10974
Advantage
58
Nanjing Yushengkang Biotechnology Co., Ltd
Tel
13327808530
Email
2670965693@qq.com
Country
China
ProdList
2179
Advantage
58
Auonsi (Shanghai) Biology Technology Co., Ltd.
Tel
400-1107768 15058188853
Fax
0571-88150696
Email
478133536@qq.com
Country
China
ProdList
8555
Advantage
58
Zhejiang Jiekun Biotechnology Co., Ltd
Tel
0571-88211951 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
4904
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5019
Advantage
58
Wuhan Peptide Core Biotechnology Co., Ltd
Tel
027-65317797 13667154760
Email
1096814016@qq.com
Country
China
ProdList
9770
Advantage
58
Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983 19135651983
Email
18611134419@163.com
Country
China
ProdList
4977
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-61856358 15829046862
Email
1035@dideu.com
Country
China
ProdList
10011
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
More
Less

View Lastest Price from NEUROMEDIN B manufacturers

Career Henan Chemical Co
Product
NEUROMEDIN B 87096-84-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

87096-84-2, NEUROMEDIN BRelated Search:


  • NEUROMEDIN B (HUMAN, PORCINE, RAT)
  • NEUROMEDIN B (HUMAN, PORCINE, RAT) ACOH 5H2O
  • NEUROMEDIN B, PORCINE
  • NEUROMEDIN B
  • H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
  • GNLWATGHFM-NH2
  • GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
  • GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O
  • NEUROMEDIN B, PORCINE MAMMALIAN BOMBESIN -LI
  • Gly-L-Asn-L-Leu-L-Trp-L-Ala-L-Thr-Gly-L-His-L-Phe-L-Met-NH2
  • LEU-SER-TRP-ASP-LEU-PRO-GLU-PRO-ARG-SER-ARG-ALA-GLY-LYS-ILE-ARG-VAL-HIS-PRO-ARG-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2: LSWDLPEPRSRAGKIRVHPRGNLWATGHFM-NH2
  • NEUROMEDIN B ≥90%
  • Neuromedin B (pig spinal cord)
  • Pig neuromedin B
  • Porcine neuromedin B
  • Neuromedin B (swinespinal cord) (9CI)
  • NEUROMEDIN BNEUROMED
  • ANTI-NMB (CENTER) antibody produced in rabbit
  • NMB
  • Neuromedin B, ≥90% (HPLC)
  • Neuromedin B (swine spinal cord)
  • Neuromedin B (porcin
  • Inhibitor,inhibit,Neuromedin B,Endogenous Metabolite
  • L-Methioninamide, glycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl-
  • 87096-84-2
  • C52H73N15O12S
  • C52H73N15O12S1
  • Cancer Research
  • BioChemical
  • Tumor Promotors
  • Tumor Growth Regulation
  • Peptide
  • BombesinsCancer Research
  • Neuropeptides
  • Peptides for Cell Biology
  • Tumor Growth Regulation
  • Tumor Promotors
  • Neuromedins and related