NEUROMEDIN U (RAT)
- Product Name
- NEUROMEDIN U (RAT)
- CAS No.
- 117505-80-3
- Chemical Name
- NEUROMEDIN U (RAT)
- Synonyms
- NMU-23;NMU, RAT;neuromedin U;NMU-23 (RAT);neuromedin U-23;NEUROMEDIN U (RAT);Rat neuromedin U-23;YKVNEYQGPVAPSGGFFLFRPRN-NH2;NeuroMedin U-23 (rat) NMU-23;H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-
- CBNumber
- CB4741505
- Molecular Formula
- C124H180N34O31
- Formula Weight
- 2642.97
- MOL File
- 117505-80-3.mol
NEUROMEDIN U (RAT) Property
- storage temp.
- −20°C
- form
- lyophilized powder
- Water Solubility
- Soluble to 1 mg/ml in Water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J66682
- Product name
- Neuromedin U, rat
- Packaging
- 0.5mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- J66682
- Product name
- Neuromedin U, rat
- Packaging
- 1mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- N2171-80Q
- Product name
- Neuromedin U
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- N2171-80P
- Product name
- Neuromedin U
- Packaging
- 100ug
- Price
- $715
- Updated
- 2021/12/16
- Product number
- PEP0002607
- Product name
- NEUROMEDIN U, RAT
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $759.07
- Updated
- 2021/12/16
NEUROMEDIN U (RAT) Chemical Properties,Usage,Production
Biological Activity
Neuromedin U, rat is a 23 amino acid brain-gut peptide that regulates several important physiological functions including energy balance, stress response and nociception through its cognate receptor NMUR2 in the central nervous system.
in vitro
To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy) 2+ 3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy) 2 + 3 -ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy) 2+ 3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection . Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy) 2+ 3 -NMU-23 to human NMUR2 receptors. From binding experiments, the K i values for NMU-23 is determined to be 4.7 nM.
target
NMUR2
NEUROMEDIN U (RAT) Preparation Products And Raw materials
Raw materials
Preparation Products
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