ChemicalBook > CAS DataBase List > NEUROMEDIN U (RAT)

NEUROMEDIN U (RAT)

Product Name: NEUROMEDIN U (RAT)
CAS No.: 117505-80-3
Chemical Name: NEUROMEDIN U (RAT)
Synonyms: NMU-23;NMU, RAT;neuromedin U;NMU-23 (RAT);neuromedin U-23;NEUROMEDIN U (RAT);Rat neuromedin U-23;YKVNEYQGPVAPSGGFFLFRPRN-NH2;NeuroMedin U-23 (rat) NMU-23;H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-
CBNumber: CB4741505
Molecular Formula: C124H180N34O31
Formula Weight: 2642.97
MOL File: 117505-80-3.mol

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NEUROMEDIN U (RAT) Property

storage temp.: −20°C
form: lyophilized powder
Water Solubility: Soluble to 1 mg/ml in Water
Sequence: Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: N2171-80Q
Product name: Neuromedin U
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: N2171-80P
Product name: Neuromedin U
Packaging: 100ug
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002607
Product name: NEUROMEDIN U, RAT
Purity: 95.00%
Packaging: 2MG
Price: $759.07
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002607
Product name: NEUROMEDIN U, RAT
Purity: 95.00%
Packaging: 5MG
Price: $1036.22
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0002607
Product name: NEUROMEDIN U, RAT
Purity: 95.00%
Packaging: 1MG
Price: $693.57
Updated: 2021/12/16

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NEUROMEDIN U (RAT) Chemical Properties,Usage,Production

Uses

Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

Biological Activity

Neuromedin U, rat is a 23 amino acid brain-gut peptide that regulates several important physiological functions including energy balance, stress response and nociception through its cognate receptor NMUR2 in the central nervous system.

in vitro

To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy) ²⁺ ₃ and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy) ^{2 +} ₃ -ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy) ²⁺ ₃ label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection . Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy) ²⁺ ₃ -NMU-23 to human NMUR2 receptors. From binding experiments, the K _i values for NMU-23 is determined to be 4.7 nM.

target

NMUR2

References

[1] Liu JJ, et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009 Jul;330(1):268-75. DOI:10.1124/jpet.109.152967

NEUROMEDIN U (RAT) Preparation Products And Raw materials

Raw materials

Preparation Products

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117505-80-3, NEUROMEDIN U (RAT)Related Search:

NEUROMEDIN N (RAT, MOUSE, PORCINE, CANINE) ANTI-NEUROMEDIN S (RAT) NEUROMEDIN S (RAT) BIOTINYL-NEUROMEDIN S (RAT) NEUROMEDIN U (RAT)

neuromedin U-23

NEUROMEDIN U (RAT)

NMU-23 (RAT)

NMU, RAT

YKVNEYQGPVAPSGGFFLFRPRN-NH2

TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2

H-TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2

neuromedin U

H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-

L-Tyr-L-Lys-L-Val-L-Asn-L-Glu-L-Tyr-L-Gln-Gly-L-Pro-L-Val-L-Ala-L-Pro-L-Ser-Gly-Gly-L-Phe-L-Phe-L-Leu-L-Phe-L-Arg-L-Pro-L-Arg-L-Asn-NH2

Neuromedin U 25 (pig spinal cord), 1-L-tyrosine-4-L-asparagine-6-L-tyrosine-7-de-L-phenylalanine-11-de-L-isoleucine-13-L-alanine-14-L-proline-15-L-serine-16-glycine-17-glycine-18-L-phenylalanine-

NeuroMedin U-23 (rat) NMU-23

NMU-23

Rat neuromedin U-23

L-Aspartamide, L-tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-α-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-

L-Tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-α-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide

117505-80-3

C124H180N34O31

Peptide