3-FLUOROCATECHOL
- Product Name
- 3-FLUOROCATECHOL
- CAS No.
- 363-52-0
- Chemical Name
- 3-FLUOROCATECHOL
- Synonyms
- 3-FLUOROCATECHOL;3-Fluorocatechol>3-Fluorocatechol,99%;3-Fluorocatechol 99%;3-FLUOROCATECHOL 98+%;3-Fluoro-1,2-benzenediol;3-FLUOROBENZENE-1,2-DIOL;3-Fluorobenznen-1,2-diol;3-Fluoro-2-hydroxy-phenol;1,2-Benzenediol, 3-fluoro-
- CBNumber
- CB1329210
- Molecular Formula
- C6H5FO2
- Formula Weight
- 128.1
- MOL File
- 363-52-0.mol
3-FLUOROCATECHOL Property
- Melting point:
- 71-73 °C (lit.)
- Boiling point:
- 218.4±20.0 °C(Predicted)
- Density
- 1.5140
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 8.54±0.10(Predicted)
- form
- Crystalline Powder
- color
- Light beige to light brown-gray
- Sensitive
- Light Sensitive
- BRN
- 2436074
- InChI
- InChI=1S/C6H5FO2/c7-4-2-1-3-5(8)6(4)9/h1-3,8-9H
- InChIKey
- DXOSJQLIRGXWCF-UHFFFAOYSA-N
- SMILES
- C1(C(F)=CC=CC=1O)O
- CAS DataBase Reference
- 363-52-0(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 20/21/22-34
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29081990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H318Causes serious eye damage
H332Harmful if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0282
- Product name
- 3-Fluorocatechol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- F0282
- Product name
- 3-Fluorocatechol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- F588825
- Product name
- 3-Fluorocatechol
- Packaging
- 50g
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- JK398255
- Product name
- 3-Fluorocatechol
- Packaging
- 1g
- Price
- $46
- Updated
- 2021/12/16
- Product number
- HCH0021907
- Product name
- 3-FLUOROCATECHOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $837.38
- Updated
- 2021/12/16
3-FLUOROCATECHOL Chemical Properties,Usage,Production
Chemical Properties
light beige to light brown-grey crystalline powder
Uses
3-Fluorocatechol is a fluorinated catechol used in the preparation of synthetic humic acid as well as an intermediate in the preparation of 3-fluoroveratrole.
Definition
ChEBI: A catechol bearing an additional fluoro substituent at position 3.
Synthesis
367-12-4
363-52-0
The general procedure for the synthesis of 3-fluorocatechol from 2-fluorophenol was as follows: o-fluorophenol (20 g, 0.2 mol) was dissolved in acetonitrile (500 mL) dried over molecular sieves and stirred under argon protection. Anhydrous magnesium chloride (68 g, 0.72 mol) and triethylamine (150 mL, 1.08 mol) were then added and the mixture was observed to be exothermic. After stirring for 20 minutes, paraformaldehyde (42 g) was added and the reaction mixture was kept at 50 °C for 6 hours. The reaction process was monitored by thin layer chromatography (TLC) and it was found that there were still residues of raw materials, but the prolongation of the reaction time did not significantly change the results. Upon completion of the reaction, the mixture was cooled to room temperature and an aqueous sodium hydroxide solution (22.8 g of sodium hydroxide dissolved in 80 mL of water) was slowly added under ice water bath conditions. Then 30 wt% hydrogen peroxide (140 mL) was slowly added dropwise, taking care to control the reaction temperature below 50 °C to avoid intense exotherm. After the dropwise addition, the reaction mixture was continued to be stirred at 30°C for 1.5 hours. Subsequently, the pH was adjusted to 1 with concentrated hydrochloric acid (12 mol/L) and extracted with ethyl acetate (4 x 100 mL). The organic phases were combined and saturated aqueous sodium thiosulfate (200 mL) was added and stirred for 1 hour to remove residual peroxide. After separation of the organic phase, the aqueous phase was again extracted with ethyl acetate (1 x 100 mL). All organic phases were combined, dried and concentrated with anhydrous magnesium sulfate. Finally, the residue was purified by column chromatography (eluent was petroleum ether/ethyl acetate, 15:1, v/v) to afford 10.3 g of a light yellow oily liquid (Intermediate C-1a) in 45% yield and recovered 4.3 g of o-fluorophenol.The NMR hydrogen spectral (300 MHz, CDCl3) data for the Intermediate C-1a were as follows:δ 6.63-6.45 (3H, m), δ 120.3 (d, J = 15.5 Hz), 111.6 (d, J = 2.6 Hz), 108.1 (d, J = 18.4 Hz).
References
[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 7, p. 1429 - 1438
[2] Patent: CN104557654, 2017, B. Location in patent: Paragraph 0091-0093
[3] Tetrahedron Letters, 2005, vol. 46, # 19, p. 3357 - 3358
[4] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2426 - 2429
[5] Patent: CN102850335, 2017, B. Location in patent: Paragraph 0018-0019
3-FLUOROCATECHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUOROCATECHOL manufacturers
- Product
- 3-FLUOROCATECHOL 363-52-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- 3-Fluorocatechol 363-52-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 3-FLUOROCATECHOL 363-52-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-06-11