2-FLUORO-6-METHOXYPHENOL
- Product Name
- 2-FLUORO-6-METHOXYPHENOL
- CAS No.
- 73943-41-6
- Chemical Name
- 2-FLUORO-6-METHOXYPHENOL
- Synonyms
- 2-FLUORO-6-METHOXYPHENOL;2-Methoxy-6-fluorophenol;2-Hydroxy-3-fluoroanisole;Phenol, 2-fluoro-6-methoxy-;2-Fluoro-6-methoxyphenol98%;2-Fluoro-6-methoxyphenol 98%
- CBNumber
- CB2118840
- Molecular Formula
- C7H7FO2
- Formula Weight
- 142.13
- MOL File
- 73943-41-6.mol
2-FLUORO-6-METHOXYPHENOL Property
- Boiling point:
- 130-131 °C36 mm Hg(lit.)
- Density
- 1.23 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.52(lit.)
- Flash point:
- 218 °F
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.71±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to light brown
- Specific Gravity
- 1.230
- InChI
- InChI=1S/C7H7FO2/c1-10-6-4-2-3-5(8)7(6)9/h2-4,9H,1H3
- InChIKey
- YZNHPLVFLRSVHY-UHFFFAOYSA-N
- SMILES
- C1(O)=C(OC)C=CC=C1F
- CAS DataBase Reference
- 73943-41-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F597528
- Product name
- 2-Fluoro-6-methoxyphenol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597528
- Product name
- 2-Fluoro-6-methoxyphenol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F597528
- Product name
- 2-Fluoro-6-methoxyphenol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 008959
- Product name
- 2-Fluoro-6-methoxyphenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 2601-3-44
- Product name
- 2-Fluoro-6-methoxyphenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
2-FLUORO-6-METHOXYPHENOL Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to light brown liquid
Synthesis
456-49-5
73943-41-6
The general procedure for the synthesis of 2-fluoro-6-methoxyphenol from m-fluoroanisole was as follows: 4.0 mL (9.4 mmol) of 2.36 M n-butyllithium solution was slowly added dropwise over a period of 1 h to 10.0 mL of anhydrous tetrahydrofuran (THF) solution containing 1.28 g (10 mmol) of m-fluoroanisole (1) according to the method of Ladd and Weinstock The reaction temperature was maintained below -65 °C and cooled using a dry ice/acetone bath. The reaction mixture was stirred at -78 °C and under nitrogen protection for 2 hours. Subsequently, 1.17 g (11 mmol) of trimethoxyborane dissolved in 2.00 mL of anhydrous THF was added dropwise over 1 h at -78 °C and stirring was continued at -78 °C for 30 min. The reaction mixture was slowly warmed to 0 °C and 0.88 mL (15 mmol) of glacial acetic acid was added, followed by the dropwise addition of 1 mL (10 mmol) of 30% hydrogen peroxide (H2O2) solution. The reaction mixture was stirred at 25 °C overnight. After completion of the reaction, the reaction solution was diluted with 10 mL of water and extracted with THF (2 × 10 mL). The organic phases were combined and washed sequentially with H2O (2 × 7 mL) and 10% brine (2 × 3 mL). The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give 1.16 g (80% yield) of 2-fluoro-6-methoxyphenol. The yields of successive replicate experiments were as follows: 15.5 g of product (63% yield) was obtained from 174 mmol of feedstock; 29.7 g of product (80% yield) was obtained from 261 mmol of feedstock. The structures of the products were analyzed by 1H NMR (300 MHz, CDCl3) δ 6.82-6.63 (m, 1H), 5.51 (s, 1H), 3.90 (s, 1H); 19F NMR (282 MHz, CDCl3) δ -137.61 ppm (m, 1F); EI-MS: m/z 142 (M+), 127.
References
[1] Synlett, 2014, vol. 25, # 20, p. 2891 - 2894
[2] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0405
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2204 - 2211
[4] Journal of Organic Chemistry, 1981, vol. 46, # 1, p. 203 - 206
[5] Journal of Chemical Research, Miniprint, 1986, # 1, p. 171 - 193
2-FLUORO-6-METHOXYPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-6-METHOXYPHENOL manufacturers
- Product
- 2-FLUORO-6-METHOXYPHENOL 73943-41-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-12-18