2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name: 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 5174-90-3
Chemical Name: 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms: 3-ethoxycarbonyl-1,8-naphthyridin-2-olate;1,2-Dihydro-3-(ethoxycarbonyl)-2-oxo-1,8-naphthyridine;Ethyl 1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate;Ethyl 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;Ethyl 1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate 95+%;2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;1,8-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester
CBNumber: CB1334450
Molecular Formula: C11H10N2O3
Formula Weight: 218.21
MOL File: 5174-90-3.mol

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2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 214.8-215.0°C
storage temp.: Sealed in dry,Room Temperature
form: solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2932209090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000832
Product name: 2-Oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TRC

Product number: O991955
Product name: 2-Oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 018155
Product name: 2-Oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
Purity: 95+%
Packaging: 500mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: 4759AE
Product name: 2-Oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
Packaging: 5g
Price: $519
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021678
Product name: 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 500MG
Price: $683.53
Updated: 2021/12/16

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2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

7521-41-7

105-53-3

5174-90-3

General procedure for the synthesis of ethyl 2-oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylate from 2-amino-3-pyridinecarboxaldehyde and diethyl malonate: 2-amino-3-pyridinecarboxaldehyde (1.0 g, 8.19 mmol) was suspended in a screw-capped pressure tube containing diethyl malonate (6.2 mL, 41.0 mmol). The reaction tube was sealed by the addition of piperidine (1.6 mL, 16.4 mmol). The reaction mixture was heated to 120°C and the reaction was kept at a constant temperature for 3.0 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature. The precipitate formed was collected by filtration and washed with ether (Et2O) to afford ethyl 2-oxo-1,2-dihydro-[1,8]naphthyridine-3-carboxylate 1.62 g in 91% yield. The structure of the product was confirmed by 1H NMR (CD3OD): δ 8.64 (m, 1H), 8.62 (s, 1H), 8.22 (m, 1H), 7.32 (m, 1H), 4.38 (m, 2H), 1.40 (t, 3H).

References

[1] Patent: WO2010/97410, 2010, A1. Location in patent: Page/Page column 121
[2] Patent: US2012/40942, 2012, A1. Location in patent: Page/Page column 56
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 12, p. 3644 - 3651
[4] Archiv der Pharmazie, 2015, vol. 348, # 1, p. 34 - 45
[5] Chemical Biology and Drug Design, 2014, vol. 84, # 6, p. 721 - 731

2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

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5174-90-3, 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester ETHYL 3-(2-AMINOPYRIDIN-3-YL)ACRYLATE 3-(4-AMINOPYRIDIN-3-YL)ACRYLIC ACID Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate 7-Bromo-4-oxo-1,4-dihydro-[1,5]naphthyridine-2-carboxylic acid ethyl ester 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL 3-(PYRIDIN-2-YLAMINO)PROPANOATE ETHYL 3-(3-PYRIDYL)ACRYLATE 2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER CHEMPACIFIC 38170 4-METHYL-2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester 6-(4-Amino-5-pyrimidinyl)-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid ethyl ester 1-(3,4-DICHLORO-PHENYL)-4-OXO-1,4-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 6-(1-Isoquinolyl)-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid ethyl ester 6-(3,4-Dimethoxyphenethyl)-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid ethyl ester

2-OXO-1,2-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

1,2-Dihydro-3-(ethoxycarbonyl)-2-oxo-1,8-naphthyridine

Ethyl 1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate 95+%

3-ethoxycarbonyl-1,8-naphthyridin-2-olate

1,8-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester

Ethyl 1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylate

5174-90-3

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