Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- Product Name
- Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- CAS No.
- 10128-91-3
- Chemical Name
- Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- Synonyms
- SPECS AE-508/36398048;Methyl2-hydroxynicotinate,97%;Methyl 6-hydroxypyridin-3-carboxylate;2-Hydroxy-nicotinic acid methyl ester;1,2-Dihydro-3-(methoxycarbonyl)-2-oxopyridine;Methyl 2-oxo-l,2-dihydropyridine-3-carboxylate;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate;3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB7717675
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 10128-91-3.mol
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Property
- Melting point:
- 115-118°C
- Boiling point:
- 367.6±42.0 °C(Predicted)
- Density
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 10.07±0.10(Predicted)
- form
- Solid
- color
- Cream
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M323558
- Product name
- Methyl2-hydroxynicotinate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H56-1-2H
- Product name
- Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate
- Packaging
- 5G
- Price
- $176
- Updated
- 2021/12/16
- Product number
- CHM0030525
- Product name
- METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1115.96
- Updated
- 2021/12/16
- Product number
- CHM0030525
- Product name
- METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1585.35
- Updated
- 2021/12/16
- Product number
- CHM0030525
- Product name
- METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $722.8
- Updated
- 2021/12/16
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Chemical Properties,Usage,Production
Uses
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
67-56-1
609-71-2
10128-91-3
Sulfuric acid (15 mL) and toluene (100 mL) were added to a concentrated solution of 2-hydroxynicotinic acid (50 g) in methanol (500 mL). The reaction mixture was stirred at room temperature for 28 hours before a Dean-Stark reflux device was installed and the reaction solution was neutralized with aqueous potassium carbonate, followed by evaporation of the solvent. Saturated aqueous ammonium chloride and chloroform were added to the residue, the organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford methyl 2-hydroxynicotinate (46 g, 84% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ: 3.92 (s, 3H), 6.45 (dd, J=7.3,6.4 Hz, 1H), 7.78 (dd, J=6.4,2.4 Hz, 1H). 8.29 (dd, J=7.3,2.4Hz, 1H).
References
[1] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[2] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[3] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0404
[5] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0331
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate manufacturers
- Product
- METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE 10128-91-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- methyl 2-oxo-1,2-dihydropyridine-3-carboxylate 10128-91-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 10128-91-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25