ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE

Product Name: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
CAS No.: 10350-10-4
Chemical Name: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
Synonyms: AURORA KA-3793;ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE;ethyl 6-methyl-2,4-dioxo-1H-pyridine-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-pyridinone-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-carboxylate;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester;4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester;1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester
CBNumber: CB5330652
Molecular Formula: C9H11NO4
Formula Weight: 197.19
MOL File: 10350-10-4.mol

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ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Property

Melting point:: 216-222°C
Boiling point:: 362.9±42.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.50±1.00(Predicted)
Appearance: White to light yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E916555
Product name: Ethyl 2,4-Dihydroxy-6-methylnicotinate
Packaging: 5mg
Price: $195
Updated: 2021/12/16

Oakwood

Product number: 021526
Product name: Ethyl4-Hydroxy-6-methyl-2-pyridone-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $13
Updated: 2021/12/16

Oakwood

Product number: 021526
Product name: Ethyl4-Hydroxy-6-methyl-2-pyridone-3-carboxylate
Purity: 97%
Packaging: 5g
Price: $43
Updated: 2021/12/16

AK Scientific

Product number: Y6874
Product name: Ethyl 2,4-Dihydroxy-6-methylnicotinate
Packaging: 1g
Price: $68
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0029731
Product name: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $823.46
Updated: 2021/12/16

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ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.

Synthesis

626-34-6

105-53-3

10350-10-4

The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at the same temperature for 24 hours. After completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of alkaline activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2~3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%).

References

[1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765

ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Suppliers

Austria 1 Belgium 1 China 72 Germany 1 India 6 Switzerland 2 United Kingdom 3 United States 8 Global 94

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View Lastest Price from ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE 10350-10-4
Price: US $1.00/KG
Min. Order: 1IU
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

10350-10-4, ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATERelated Search:

Nicotinic acid ETHYL STEARATE Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate AURORA KA-5524 AURORA KA-5497 3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE AURORA KA-5270

ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE

ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE

ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE

AURORA KA-3793

1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester

1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester

4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester

3-Pyridinecarboxylic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester

3-Pyridinecarboxylic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester (9CI, ACI)

1,2-dihydro-4-hydroxy-6-methyl-2-oxo-3-Pyridinecarboxylic acid ethyl ester (9CI ACI)

Ethyl 4-hydroxy-6-methyl-2-pyridinone-3-carboxylate

ethyl 6-methyl-2,4-dioxo-1H-pyridine-3-carboxylate

Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-carboxylate

10350-10-4

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