ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
- Product Name
- ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
- CAS No.
- 10350-10-4
- Chemical Name
- ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
- Synonyms
- AURORA KA-3793;ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE;ethyl 6-methyl-2,4-dioxo-1H-pyridine-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-pyridinone-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-carboxylate;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester;4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester;1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester
- CBNumber
- CB5330652
- Molecular Formula
- C9H11NO4
- Formula Weight
- 197.19
- MOL File
- 10350-10-4.mol
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Property
- Melting point:
- 216-222°C
- Boiling point:
- 362.9±42.0 °C(Predicted)
- Density
- 1.308±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.50±1.00(Predicted)
- Appearance
- White to light yellow Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E916555
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Packaging
- 5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 021526
- Product name
- Ethyl4-Hydroxy-6-methyl-2-pyridone-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 021526
- Product name
- Ethyl4-Hydroxy-6-methyl-2-pyridone-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- Y6874
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- CHM0029731
- Product name
- ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $823.46
- Updated
- 2021/12/16
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.
Synthesis
626-34-6
105-53-3
10350-10-4
The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at the same temperature for 24 hours. After completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of alkaline activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2~3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%).
References
[1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE Suppliers
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- Fax
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- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE 10350-10-4
- Price
- US $1.00/KG
- Min. Order
- 1IU
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07