ChemicalBook > CAS DataBase List > Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

Product Name
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
CAS No.
10128-91-3
Chemical Name
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
Synonyms
SPECS AE-508/36398048;Methyl2-hydroxynicotinate,97%;Methyl 6-hydroxypyridin-3-carboxylate;2-Hydroxy-nicotinic acid methyl ester;1,2-Dihydro-3-(methoxycarbonyl)-2-oxopyridine;Methyl 2-oxo-l,2-dihydropyridine-3-carboxylate;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate;3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ISO 9001：2015 REACH
CBNumber
CB7717675
Molecular Formula
C7H7NO3
Formula Weight
153.14
MOL File
10128-91-3.mol
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Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Property

Melting point:
115-118°C
Boiling point:
367.6±42.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
10.07±0.10(Predicted)
form 
Solid
color 
Cream
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M323558
Product name
Methyl2-hydroxynicotinate
Packaging
100mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
044742
Product name
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity
>95%
Packaging
500mg
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
044742
Product name
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity
>95%
Packaging
1g
Price
$30
Updated
2021/12/16
Apolloscientific
Product number
OR16841
Product name
Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-2H
Product name
Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate
Packaging
1g
Price
$88
Updated
2021/12/16
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Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Chemical Properties,Usage,Production

Uses

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

67-56-1

609-71-2

10128-91-3

Sulfuric acid (15 mL) and toluene (100 mL) were added to a concentrated solution of 2-hydroxynicotinic acid (50 g) in methanol (500 mL). The reaction mixture was stirred at room temperature for 28 hours before a Dean-Stark reflux device was installed and the reaction solution was neutralized with aqueous potassium carbonate, followed by evaporation of the solvent. Saturated aqueous ammonium chloride and chloroform were added to the residue, the organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford methyl 2-hydroxynicotinate (46 g, 84% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ: 3.92 (s, 3H), 6.45 (dd, J=7.3,6.4 Hz, 1H), 7.78 (dd, J=6.4,2.4 Hz, 1H). 8.29 (dd, J=7.3,2.4Hz, 1H).

References

[1] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[2] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[3] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0404
[5] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0331

Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE 10128-91-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Henan Aochuang Chemical Co.,Ltd.
Product
methyl 2-oxo-1,2-dihydropyridine-3-carboxylate 10128-91-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Career Henan Chemical Co
Product
METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 10128-91-3
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

10128-91-3, Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylateRelated Search:

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 2-PHENOXYNICOTINATE ETHYL 5-(AMINOCARBONYL)-4-METHYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE DIETHYL 2-(2-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 1-(2,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE DIETHYL 2-HYDROXY-6-[2-(1-METHYL-4-PIPERIDINYLIDENE)HYDRAZINO]-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-(2-[1-(6-FLUORO-2-PYRIDINYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 5-CHLORO-1-(4-CHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ETHYL 5-CYANO-6-[4-(4-METHOXYPHENYL)PIPERAZINO]-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 1-(2,6-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 5-CHLORO-2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE DIETHYL 2-[2-(1-BENZYL-4-PIPERIDINYLIDENE)HYDRAZINO]-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE METHYL 5-CHLORO-1-(3,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 1-(2-CHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE METHYL 1-(3-CHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ETHYL 5-CYANO-6-ETHOXY-2-HYDROXYNICOTINATE

  • METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
  • SPECS AE-508/36398048
  • 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester
  • Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate
  • 2-Hydroxy-nicotinic acid methyl ester
  • Methyl 6-hydroxypyridin-3-carboxylate
  • 1,2-Dihydro-3-(methoxycarbonyl)-2-oxopyridine
  • Methyl 2-oxo-l,2-dihydropyridine-3-carboxylate
  • Methyl2-hydroxynicotinate,97%
  • METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ISO 9001：2015 REACH
  • TIANFUCHEM--10128-91-3--High purity METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE in stock
  • 10128-91-3
  • Esters
  • Pyridines