PD-1/PD-L1 Inhibitor 3
- Product Name
- PD-1/PD-L1 Inhibitor 3
- CAS No.
- 1629654-95-0
- Chemical Name
- PD-1/PD-L1 Inhibitor 3
- Synonyms
- PD-1/PD-L1-IN 3;PD-1/PD-L1 Inhibitor 3;PD-1/PD-L1 Inhibitor 3 TFA;PD-1/PD-L1 Inhibitor 3 USP/EP/BP;Glycinamide, N-(2-mercaptoacetyl)-L-phenylalanyl-N-methyl-L-alanyl-L-asparaginyl-L-prolyl-L-histidyl-L-leucyl-N-methylglycyl-L-tryptophyl-L-seryl-L-tryptophyl-N-methyl-L-norleucyl-N-methyl-L-norleucyl-L-arginyl-L-cysteinyl-, cyclic (1→14)-thioether
- CBNumber
- CB13362748
- Molecular Formula
- C89H126N24O18S
- Formula Weight
- 1852.17
- MOL File
- 1629654-95-0.mol
PD-1/PD-L1 Inhibitor 3 Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.14±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- B6191
- Product name
- PD-1/PD-L1Inhibitor3
- Packaging
- 5mg
- Price
- $1047
- Updated
- 2021/12/16
- Product number
- DC44154
- Product name
- PD-1/PD-L1-IN3
- Purity
- >98%
- Packaging
- 25mg
- Price
- $750
- Updated
- 2021/12/16
PD-1/PD-L1 Inhibitor 3 Chemical Properties,Usage,Production
Biological Activity
pd-1/pd-l1 inhibitor 3 is a pd-1/pd-l1 interaction inhibitor.the anti-pd-1 and anti-pd-l1 compounds have been found to show impressive antitumor effects in various malignancies, such as melanoma. the greatest clinical outcome in unselected patients has been observed in melanoma. the tumor expression of pd-l1 is suggested to be a suggestive, inadequate, and predictive of response to immune-checkpoint blockade.
in vitro
pd-1/pd-l1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1) and with cd80. pd-1/pd-l1 inhibitor 3 was also found to act as an immunomodulator. in addition, pd-1/pd-l1 inhibitor 3 was found to have highly efficacious binding to pd-l1 and promote the increased functional activities of t cells. therefore, pd-1/pd-l1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis c [1].
target
| Target | Value |
| PD-1/PD-L1 interaction (Cell-free assay ) | 5.6 nM |
References
[1] miller michael matthew, et al. patent, pub. no.:wo/2014/151634
PD-1/PD-L1 Inhibitor 3 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PD-1/PD-L1 Inhibitor 3 manufacturers
- Product
- PD-1/PD-L1 Inhibitor 3 1629654-95-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-05-18
- Product
- PD-1/PD-L1 Inhibitor 3 1629654-95-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17