Val-Ala-PAB

Product Name: Val-Ala-PAB
CAS No.: 1343476-44-7
Chemical Name: Val-Ala-PAB
Synonyms: Val-Ala-PAB-OH;(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide;CS-2747;Val-Ala-PAB;H-Val-Ala-PAB;Val Ala PAB,ValAlaPAB;L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-;(2S)-2-amino-N-[(1S)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl]-3-methylbutanamide;(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide;(S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide
CBNumber: CB13364146
Molecular Formula: C15H23N3O3
Formula Weight: 293.36
MOL File: 1343476-44-7.mol

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Val-Ala-PAB Property

Melting point:: 65-68°C
Boiling point:: 584.9±50.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: -20°C, Inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.51±0.70(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 1g
Price: $1210
Updated: 2021/12/16

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 5g
Price: $4400
Updated: 2021/12/16

TRC

Product number: V091550
Product name: Val-Ala-PAB
Packaging: 25g
Price: $18700
Updated: 2021/12/16

Ambeed

Product number: A1492902
Product name: (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
Purity: 97%
Packaging: 50mg
Price: $163
Updated: 2021/12/16

Ambeed

Product number: A1492902
Product name: (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide
Purity: 97%
Packaging: 100mg
Price: $249
Updated: 2021/12/16

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Val-Ala-PAB Chemical Properties,Usage,Production

Description

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.

Val-Ala-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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Val-Ala-PAB Suppliers

China 45 United States 4 Global 49

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

Tel: 13414494621
Fax: qq: 30307604
Email: chenchao02lzu@126.com
Country: China
ProdList: 122
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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Advantage: 64

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
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Country: China
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Hygeia (Chengdu) pharmaceutical technique Co., Ltd

Tel: 028-84502008 13568869383
Fax: 028-66476329
Email: sales@hygeiapharm.com
Country: China
ProdList: 297
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4456
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

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Email: hailey@shsendpharm.com
Country: China
ProdList: 3129
Advantage: 55

Shanghai Chaolan Chemical Technology Center

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Heze Development Zone chuangli Chemical Co., Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4824
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SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3571
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View Lastest Price from Val-Ala-PAB manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Val-Ala-PAB-OH 1343476-44-7
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-29

1343476-44-7, Val-Ala-PABRelated Search:

Val-Ala-PAB

CS-2747

(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide

L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-

Val-Ala-PAB-OH

(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide

Val Ala PAB,ValAlaPAB

H-Val-Ala-PAB

(S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide

(2S)-2-amino-N-[(1S)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl]-3-methylbutanamide

1343476-44-7

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