TAK-931

Product Name: TAK-931
CAS No.: 1330782-76-7
Chemical Name: TAK-931
Synonyms: TAK-931;ZL-2309;SIMUROSERTIB;TAK-931，Simurosertib;Simurosertib (TAK-931);Simurosertib, 10 mM in DMSO;(S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one;(S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-;2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one
CBNumber: CB13364621
Molecular Formula: C17H19N5OS
Formula Weight: 341.43
MOL File: 1330782-76-7.mol

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TAK-931 Property

storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
color: White to off-white
InChI: InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8,10,13H,2-6H2,1H3,(H,18,21)(H,19,20,23)/t13-/m0/s1
InChIKey: XGVXKJKTISMIOW-ZDUSSCGKSA-N
SMILES: C1([C@@H]2CC3CCN2CC3)NC(=O)C2SC(C3=CNN=C3C)=CC=2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 2mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 5mg
Price: $230
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 10mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0020550
Product name: Simurosertib
Purity: 99.07%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC21653
Product name: Simurosertib(TAK-931)
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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TAK-931 Chemical Properties,Usage,Production

Uses

Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity[1].

in vivo

In the COLO205-xenograft mouse model, oral administration of Simurosertib (TAK-931) inhibits pMCM2 of the xenografted COLO205 in dose- and time-dependent manners. Furthermore, Simurosertib (TAK-931) exhibits a significant antitumor activity in multiple xenograft models^[1].

IC 50

Cdc7: <0.3 nM (IC₅₀)

References

[1] K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal of Cancer , 2016 , 69 (1) :S34.

TAK-931 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAK-931 Suppliers

China 63 United States 4 Global 67

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 995
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 8555
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
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Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
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1330782-76-7, TAK-931Related Search:

2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1~{H}-pyrazol-4-yl)-3~{H}-thieno[3,2-d]pyrimidin-4-one

SIMUROSERTIB

TAK-931

(S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one

Simurosertib (TAK-931)

Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-

TAK-931，Simurosertib

Inhibitor,anti-cancer,Cyclin dependent kinase,ATP-competitive,CDK,TAK931,Simurosertib,cycle,cell,orally,inhibit,division,TAK 931

2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one

(S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one

Simurosertib, 10 mM in DMSO

ZL-2309

1330782-76-7