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TAK-931

Product Name
TAK-931
CAS No.
1330782-76-7
Chemical Name
TAK-931
Synonyms
TAK-931;ZL-2309;SIMUROSERTIB;TAK-931，Simurosertib;Simurosertib (TAK-931);Simurosertib, 10 mM in DMSO;(S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one;(S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-;2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one
CBNumber
CB13364621
Molecular Formula
C17H19N5OS
Formula Weight
341.43
MOL File
1330782-76-7.mol
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TAK-931 Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
InChI
InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8,10,13H,2-6H2,1H3,(H,18,21)(H,19,20,23)/t13-/m0/s1
InChIKey
XGVXKJKTISMIOW-ZDUSSCGKSA-N
SMILES
C1([C@@H]2CC3CCN2CC3)NC(=O)C2SC(C3=CNN=C3C)=CC=2N=1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0020550
Product name
Simurosertib
Purity
99.07%
Packaging
2mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0020550
Product name
Simurosertib
Purity
99.07%
Packaging
5mg
Price
$230
Updated
2021/12/16
ChemScene
Product number
CS-0020550
Product name
Simurosertib
Purity
99.07%
Packaging
10mg
Price
$320
Updated
2021/12/16
ChemScene
Product number
CS-0020550
Product name
Simurosertib
Purity
99.07%
Packaging
50mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC21653
Product name
Simurosertib(TAK-931)
Purity
>98%
Packaging
100mg
Price
$800
Updated
2021/12/16
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TAK-931 Chemical Properties,Usage,Production

Uses

Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity[1].

in vivo

In the COLO205-xenograft mouse model, oral administration of Simurosertib (TAK-931) inhibits pMCM2 of the xenografted COLO205 in dose- and time-dependent manners. Furthermore, Simurosertib (TAK-931) exhibits a significant antitumor activity in multiple xenograft models[1].

IC 50

Cdc7: <0.3 nM (IC50)

References

[1] K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal of Cancer , 2016 , 69 (1) :S34.

TAK-931 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAK-931 Suppliers

China 62 United States 4 Global 66
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1330782-76-7, TAK-931Related Search:


  • 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1~{H}-pyrazol-4-yl)-3~{H}-thieno[3,2-d]pyrimidin-4-one
  • SIMUROSERTIB
  • TAK-931
  • (S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
  • Simurosertib (TAK-931)
  • Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-
  • TAK-931，Simurosertib
  • Inhibitor,anti-cancer,Cyclin dependent kinase,ATP-competitive,CDK,TAK931,Simurosertib,cycle,cell,orally,inhibit,division,TAK 931
  • 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)-1H,4H-thieno[3,2-d]pyrimidin-4-one
  • (S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(1H)-one
  • Simurosertib, 10 mM in DMSO
  • ZL-2309
  • 1330782-76-7