ChemicalBook > CAS DataBase List > ARS-1620

ARS-1620

Product Name
ARS-1620
CAS No.
1698055-85-4
Chemical Name
ARS-1620
Synonyms
CPD1588;ARS-1620;ARS-1620;ARS 1620;ARS1620;inhibit,Ras,Inhibitor,ARS-1620,ARS 1620,ARS1620;(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one;(S)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one;2-Propen-1-one, 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-;1-?[4-?[(7S)?-?6-?Chloro-?8-?fluoro-?7-?(2-?fluoro-?6-?hydroxyphenyl)?-?4-?quinazolinyl]?-?1-?piperazinyl]?-?2-?propen-?1-?one
CBNumber
CB13369787
Molecular Formula
C21H17ClF2N4O2
Formula Weight
430.84
MOL File
1698055-85-4.mol
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ARS-1620 Property

Boiling point:
614.7±55.0 °C(Predicted)
Density 
1.434±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM)
form 
A solid
pka
6.03±0.35(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27915
Product name
ARS1620
Packaging
1mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
27915
Product name
ARS1620
Packaging
5mg
Price
$351
Updated
2024/03/01
ChemScene
Product number
CS-0035119
Product name
ARS-1620
Purity
99.20%
Packaging
25mg
Price
$690
Updated
2021/12/16
ChemScene
Product number
CS-0035119
Product name
ARS-1620
Purity
99.20%
Packaging
50mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0035119
Product name
ARS-1620
Purity
99.20%
Packaging
100mg
Price
$1250
Updated
2021/12/16
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ARS-1620 Chemical Properties,Usage,Production

Uses

ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

Definition

ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.

ARS-1620 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARS-1620 Suppliers

ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4010
Advantage
58
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9458
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
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View Lastest Price from ARS-1620 manufacturers

Career Henan Chemical Co
Product
ARS-1620 1698055-85-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

1698055-85-4, ARS-1620Related Search:


  • ARS-1620
  • CPD1588
  • ARS-1620;ARS 1620;ARS1620
  • (S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
  • 1-?[4-?[(7S)?-?6-?Chloro-?8-?fluoro-?7-?(2-?fluoro-?6-?hydroxyphenyl)?-?4-?quinazolinyl]?-?1-?piperazinyl]?-?2-?propen-?1-?one
  • 2-Propen-1-one, 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-
  • (S)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one
  • inhibit,Ras,Inhibitor,ARS-1620,ARS 1620,ARS1620
  • 1698055-85-4
  • C21H17ClF2N4O2
  • APIs
  • API