ChemicalBook > CAS DataBase List > N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide

Product Name
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
CAS No.
827001-82-1
Chemical Name
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
Synonyms
5J 4;5J-4, 10 mM in DMSO;Orai1/CRAC Blocker, Cpd5J-4;N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide;N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide;2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-;Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
CBNumber
CB13373021
Molecular Formula
C16H12N2O3S
Formula Weight
312.34
MOL File
827001-82-1.mol
More
Less

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Property

Density 
1.459±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.08±0.70(Predicted)
form 
Powder
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
H826850
Product name
N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
Packaging
100mg
Price
$1050
Updated
2021/12/16
More
Less

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Chemical Properties,Usage,Production

Uses

N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide inhibits or blocks the calcium release-activated calcium (CRAC) channel for alleviation of autoimmune diseases.

Biological Activity

Primary Target
Orail1

in vivo

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].

Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
Dosage:2 m/kg
Administration:I.p., every alternate day for 30 days
Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

storage

Store at -20°C

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Suppliers

China 15 India 1 The Netherlands 1 United States 2 Global 19
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Guangzhou Yansai Biological Products Co., Ltd.
Tel
13710209565
Country
CHINA
ProdList
122
Advantage
58
Guangzhou Baide Biotechnology Co., Ltd.
Tel
18925065404
Country
CHINA
ProdList
168
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58

827001-82-1, N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamideRelated Search:


  • N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
  • 2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-
  • 5J 4
  • Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
  • 5J-4, 10 mM in DMSO
  • Orai1/CRAC Blocker, Cpd5J-4
  • N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide
  • 827001-82-1