ChemicalBook > CAS DataBase List > N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
- Product Name
- N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
- CAS No.
- 827001-82-1
- Chemical Name
- N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
- Synonyms
- 5J 4;5J-4, 10 mM in DMSO;Orai1/CRAC Blocker, Cpd5J-4;N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide;N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide;2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-;Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
- CBNumber
- CB13373021
- Molecular Formula
- C16H12N2O3S
- Formula Weight
- 312.34
- MOL File
- 827001-82-1.mol
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N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Property
- Density
- 1.459±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.08±0.70(Predicted)
- form
- Powder
- color
- White to off-white
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N-Bromosuccinimide Price
TRC
- Product number
- H826850
- Product name
- N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
- Packaging
- 100mg
- Price
- $1050
- Updated
- 2021/12/16
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N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Chemical Properties,Usage,Production
Uses
N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide inhibits or blocks the calcium release-activated calcium (CRAC) channel for alleviation of autoimmune diseases.
Biological Activity
Primary Target
Orail1
in vivo
5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].
| Animal Model: | C57BL/6 mice (MOG35-55 peptide-immunized mice)[1] |
| Dosage: | 2 m/kg |
| Administration: | I.p., every alternate day for 30 days |
| Result: | Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population. |
storage
Store at -20°C
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Preparation Products And Raw materials
Raw materials
Preparation Products
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