ARS-1630

Product Name: ARS-1630
CAS No.: 1698055-86-5
Chemical Name: ARS-1630
Synonyms: CPD2016;ARS-1630;ARS-1630, 10 mM in DMSO;ARS-1630;ARS 1630;ARS1630;inhibit,Ras,ARS-1630,ARS1630,Inhibitor,ARS 1630;1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl}prop-2-en-1-one;(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one;2-Propen-1-one, 1-[4-[(7R)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-
CBNumber: CB13386449
Molecular Formula: C21H17ClF2N4O2
Formula Weight: 430.84
MOL File: 1698055-86-5.mol

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ARS-1630 Property

Boiling point:: 614.7±55.0 °C(Predicted)
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 69 mg/mL (160.15 mM)
form: Solid
pka: 6.03±0.35(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0035117
Product name: ARS-1630
Purity: 98.01%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0035117
Product name: ARS-1630
Purity: 98.01%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0035117
Product name: ARS-1630
Purity: 98.01%
Packaging: 25mg
Price: $690
Updated: 2021/12/16

ChemScene

Product number: CS-0035117
Product name: ARS-1630
Purity: 98.01%
Packaging: 50mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0035117
Product name: ARS-1630
Purity: 98.01%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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ARS-1630 Chemical Properties,Usage,Production

Uses

ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.

Definition

ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.

IC 50

KRAS(G12C)

References

[1] Liansheng Li, et al. Inhibitors of kras g12c. WO 2015054572 A1.
[2] Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172(3):578-589.e17. DOI:10.1016/j.cell.2018.01.006

ARS-1630 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARS-1630 Suppliers

China 38 United States 5 Global 43

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30227
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1698055-86-5, ARS-1630Related Search:

ARS-1630

CPD2016

ARS-1630;ARS 1630;ARS1630

(R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

2-Propen-1-one, 1-[4-[(7R)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-

inhibit,Ras,ARS-1630,ARS1630,Inhibitor,ARS 1630

1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl}prop-2-en-1-one

ARS-1630, 10 mM in DMSO

1698055-86-5