ChemicalBook > CAS DataBase List > 5-METHOXY-2-BENZIMIDAZOLINONE

5-METHOXY-2-BENZIMIDAZOLINONE

Product Name
5-METHOXY-2-BENZIMIDAZOLINONE
CAS No.
2080-75-3
Chemical Name
5-METHOXY-2-BENZIMIDAZOLINONE
Synonyms
BUTTPARK 121\04-68;Omeprazole impurity R;Omeprazole Impurity 14;5-METHOXYBENZIMIDAZOLONE;5-METHOXYBENZIMIDAZOL-2-ONE;5-Methoxy-benzimidazolin-2-on;5-METHOXY-2-BENZIMIDAZOLINONE;5-METHOXY-BENZIMIDAZOLIN-2-ONE;Esomeprazole Sodium Impurity 44;5-Methoxybenzimidazol-2(3H)-one
CBNumber
CB1339965
Molecular Formula
C8H8N2O2
Formula Weight
164.16
MOL File
2080-75-3.mol
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5-METHOXY-2-BENZIMIDAZOLINONE Property

Melting point:
255°C (dec.)
Boiling point:
174.5±19.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO, Methanol (Slightly)
form 
Solid
pka
11.53±0.30(Predicted)
color 
Off-White to Dark Brown
BRN 
141043
CAS DataBase Reference
2080-75-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
0642AB
Product name
5-Methoxy-1H-benzo[d]imidazol-2(3H)-one
Packaging
1g
Price
$97
Updated
2021/12/16
AK Scientific
Product number
0642AB
Product name
5-Methoxy-1H-benzo[d]imidazol-2(3H)-one
Packaging
25g
Price
$667
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003359
Product name
5-METHOXY-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
Purity
95.00%
Packaging
5G
Price
$877.8
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
10855
Product name
2-Hydroxy-5-methoxybenzimidazole
Packaging
25g
Price
$1760
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003359
Product name
5-METHOXY-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
Purity
95.00%
Packaging
50G
Price
$3326.4
Updated
2021/12/16
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5-METHOXY-2-BENZIMIDAZOLINONE Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Uses

Benzimidazole derivative. An intermediate for a novel class of 2-{3-oxospiro[isobenzofuran -1(3H),4'-piperidin]-1'-yl}benzimidazole NPY Y5 receptor antagonist.

Uses

Benzimidazole derivative. An intermediate for a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4''-piperidin]-1''-yl}benzimidazole NPY Y5 receptor antagonist. An impurity of Esomeprazole, which is a gastric proton-pump inhibitor.

Uses

5-METHOXY-2-BENZIMIDAZOLINONE is a useful synthetic intermediate.

Synthesis

213118-56-0

2080-75-3

General procedure for the synthesis of 5-methoxy-1H-benzo[d]imidazol-2(3H)-one from 1,2-diamino-4-iodobenzene: Preparation of intermediate 37: Intermediate 36 (7.3 g, 30.6 mmol) was dissolved in N,N-dimethylformamide (DMF, 70 mL). Anhydrous potassium carbonate (K2CO3, 4.7 g, 33.7 mmol) was added to this solution and the mixture was heated to reflux (130 °C) for 5 h of reaction. After completion of the reaction, the solvent was removed by distillation under reduced pressure, the residue was poured into ice water and the aqueous phase was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The resulting yellow solid was recrystallized from ethanol (EtOH) to give 5-methoxy-1H-benzo[d]imidazol-2(3H)-one (Intermediate 37, 3.6 g, 72% yield) as a yellow solid with a melting point of 249-251 °C.

References

[1] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 71

5-METHOXY-2-BENZIMIDAZOLINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHOXY-2-BENZIMIDAZOLINONE Suppliers

Canada 1 China 102 Europe 1 Germany 3 India 6 Switzerland 1 United Kingdom 3 United States 14 Global 131
BOC Sciences
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View Lastest Price from 5-METHOXY-2-BENZIMIDAZOLINONE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
5-METHOXY-2-BENZIMIDAZOLINONE 2080-75-3
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2020-01-06
Nanjing jinheyou Trading Co., Ltd.
Product
5-METHOXY-2-BENZIMIDAZOLINONE 2080-75-3
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2020-01-06

2080-75-3, 5-METHOXY-2-BENZIMIDAZOLINONERelated Search:

N,N-Diisopropylethylamine 2-Methylimidazole Indole-3-carboxylic acid 5-Aminosalicylic acid Esomeprazole Impurity 3 Esomeprazole Impurity 17 5-methoxy-3H-benzooxazole-2-thione Esomeprazole Impurity 8 Esomeprazole Impurity 14 Esomeprazole Impurity 25 Esomeprazole Impurity Esomeprazole Impurity 15 2-Acetoxymethyl1-3-Methyl-4- 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine 1-Oxide 2-(((5-hydroxy-1H-benzo[d]iMidazol-2-yl)sulfinyl)Methyl)-3,5-diMethylpyridin-4(1H)-one N-oxide impurity Esomeprazole Impurity 5 N-(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl OMeprazole Sulfone

  • BUTTPARK 121\04-68
  • 1,3-Dihydro-5-methoxy-2H-benzimidazole-2-one~2-Hydroxy-5-methoxybenzimidazole
  • 1,3-dihydro-5-methoxy-2h-benzimidazole-2-one
  • 2H-Benzimidazol-2-one,1,3-dihydro-5-methoxy-(9CI)
  • 5-Methoxy-1H-benzimidazole-2(3H)-one
  • Esomeprazole Sodium Impurity 44
  • 5-Methoxy-benzimidazolin-2-on
  • 2-HYDROXY-5-METHOXYBENZIMIDAZOLE
  • 1,3-DIHYDRO-5-METHOXY-2H-BENZIMIDAZOL-2-ONE
  • 5-methoxy-1H-benzo[d]imidazol-2-ol
  • Omeprazole Impurity 14
  • Esomeprazole Impurity 4 (5-Methoxy-1, 3-Dihydro-benzoimidazol-2-One)
  • 5-Methoxy-1H-benzo[d]imidazol-2(3H)
  • 5-METHOXY-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE
  • 5-METHOXY-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
  • 5-METHOXY-2-BENZIMIDAZOLINONE
  • 5-METHOXYBENZIMIDAZOL-2-ONE
  • 5-METHOXY-BENZIMIDAZOLIN-2-ONE
  • 5-METHOXYBENZIMIDAZOLONE
  • Omeprazole impurity R
  • Esomeprazole impurity 7/2-Hydroxy-5-methoxybenzimidazole
  • 5-Methoxy-1,3-dihydrobenzimidazol-2
  • 2H-Benzimidazol-2-one, 1,3-dihydro-5-methoxy-
  • Omeprazole Imidazolinone Impurity
  • 5-Methoxybenzimidazol-2(3H)-one
  • 2080-75-3
  • BENZIMIDAZOLE
  • API intermediates
  • Aromatics Compounds
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals