ChemicalBook > CAS DataBase List > H-LEU-SER-LYS-LEU-OH
H-LEU-SER-LYS-LEU-OH
- Product Name
- H-LEU-SER-LYS-LEU-OH
- CAS No.
- 162559-45-7
- Chemical Name
- H-LEU-SER-LYS-LEU-OH
- Synonyms
- LEU-SER-LYS-LEU;H-LEU-SER-LYS-LEU-OH;L-Leucyl-L-seryl-L-lysyl-L-leucine;L-Leucine, L-leucyl-L-seryl-L-lysyl-;Inhibitor of Thrombospondin (TSP-1) (TFA)
- CBNumber
- CB1342000
- Molecular Formula
- C21H41N5O6
- Formula Weight
- 459.58
- MOL File
- 162559-45-7.mol
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H-LEU-SER-LYS-LEU-OH Property
- Boiling point:
- 803.2±65.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- pka
- 3.37±0.10(Predicted)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- INB0001591
- Product name
- LEU-SER-LYS-LEU
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $635.25
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0001591
- Product name
- LEU-SER-LYS-LEU
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $693
- Updated
- 2021/12/16
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H-LEU-SER-LYS-LEU-OH Chemical Properties,Usage,Production
Uses
H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK.html" class="link-product" target="_blank">KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis[1].
in vivo
H-Leu-Ser-Lys-Leu-OH (LSKL) (100 μg/0.5 mL; i.p.; daily for 4 weeks, accompanied with DMN) protects dimethylnitrosamine (DMN)-treated (10 mg/kg; i.p.; 3 consecutive days a week for 4 weeks) rats from liver atrophy. H-Leu-Ser-Lys-Leu-OH also prevents the progression of hepatic damage and fibrosis[1].
References
[1] Kondou H, et al. A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo. J Hepatol. 2003 Nov;39(5):742-8. DOI:10.1016/s0168-8278(03)00377-5
H-LEU-SER-LYS-LEU-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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