4-BROMO-6-METHOXYINDOLE
- Product Name
- 4-BROMO-6-METHOXYINDOLE
- CAS No.
- 393553-55-4
- Chemical Name
- 4-BROMO-6-METHOXYINDOLE
- Synonyms
- 4-BROMO-6-METHOXYINDOLE;4-BROMO-6-METHYLOXY INDOLE;4-bromo-6-methoxy-1H-indole;4-broMo-6-Methyloxyl indole;1H-Indole, 4-broMo-6-Methoxy-
- CBNumber
- CB1348446
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 393553-55-4.mol
4-BROMO-6-METHOXYINDOLE Property
- Boiling point:
- 346.8±22.0 °C(Predicted)
- Density
- 1.591±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 16.29±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C9H8BrNO/c1-12-6-4-8(10)7-2-3-11-9(7)5-6/h2-5,11H,1H3
- InChIKey
- CZJYKEPYJHPVOD-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC(OC)=C2)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B429763
- Product name
- 4-bromo-6-methoxy-1H-indole
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B429763
- Product name
- 4-bromo-6-methoxy-1H-indole
- Packaging
- 2mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 5147AB
- Product name
- 4-Bromo-6-methoxy-1H-indole
- Packaging
- 5g
- Price
- $1308
- Updated
- 2021/12/16
- Product number
- HCH0320033
- Product name
- 4-BROMO-6-METHOXYINDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.1
- Updated
- 2021/12/16
- Product number
- SC-12820
- Product name
- 4-bromo-6-methoxy-1H-indole
- Purity
- 95
- Packaging
- 1g
- Price
- $539
- Updated
- 2021/12/16
4-BROMO-6-METHOXYINDOLE Chemical Properties,Usage,Production
Synthesis
1431711-54-4
393553-55-4
General procedure for the synthesis of 4-bromo-6-methoxy-1H-indole from the compound (CAS: 1431711-54-4): (b) N-(3-bromo-5-methoxyphenyl)-N-hydroxyacetamide (360 mg, 1.384 mmol) was dissolved in vinyl acetate (1.92 mL) followed by addition of Li2PdCl4 (18.2 mg, 69 μmol). The reaction mixture was stirred at 60°C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and brine, the organic layer was separated and concentrated under reduced pressure to give a solid. The solid was dissolved in methanol (20 mL), 1N NaOH aqueous solution (2.61 mL, 2.61 mmol) was added and stirred for 2 hours at room temperature. The reaction mixture was quenched with 2N HCl aqueous solution (1.3 mL, 2.6 mmol) followed by addition of sodium carbonate (500 mg). After addition of ethyl acetate (50 mL), the organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (20 g silica gel, ethyl acetate/heptane, gradient from 0/100 to 1/4) to afford the title compound as a liquid (145 mg, 46% yield, two steps).1H-NMR (600 MHz; DMSO-d6): δ 11.26 (brs, 1H), 7.31 (dd, 1H), 6.93 (d, 1H), and 6.90 (d, 1H), 6.29 (dd, 1H), 3.78 (s, 3H).
References
[1] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 45; 46
4-BROMO-6-METHOXYINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-6-METHOXYINDOLE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4-BROMO-6-METHOXYINDOLE manufacturers
- Product
- 4-BROMO-6-METHOXYINDOLE 393553-55-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12