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CTAP

Product Name
CTAP
CAS No.
103429-32-9
Chemical Name
CTAP
Synonyms
CTAP;CTAP-NH2;CTAP,CTA;CTAP, ≥95%;7)-disulfide;CTAP, mu opioid antagonist;CYS2, TYR3, ARG5, PEN7-AMIDE;M.W. 1104.30 C51H69N13O11S2;D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
CBNumber
CB1349599
Molecular Formula
C51H69N13O11S2
Formula Weight
1104.3
MOL File
103429-32-9.mol
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CTAP Property

storage temp. 
-20°C
form 
Solid
color 
off-white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
{d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6352
Product name
CTAP
Purity
≥95%
Packaging
1mg
Price
$245
Updated
2025/07/31
Sigma-Aldrich
Product number
5.08316
Product name
CTAP - CAS 103429-32-9 - Calbiochem
Packaging
1MG
Price
$144
Updated
2025/07/31
Cayman Chemical
Product number
14959
Product name
CTAP
Packaging
1mg
Price
$79
Updated
2021/12/16
Tocris
Product number
1560
Product name
CTAP
Packaging
1
Price
$173
Updated
2021/12/16
Usbiological
Product number
255053
Product name
CTAP
Packaging
1mg
Price
$409
Updated
2021/12/16
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CTAP Chemical Properties,Usage,Production

Uses

CTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake.

Uses

CTAP has been used as a μ-opioid receptor (MOR) antagonist:

  • to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
  • to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats
  • to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons

Biochem/physiol Actions

CTAP is a peptide antagonist produced from somatostatin analogs.

in vivo

CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect[1].
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0, 0.1, 0.5, 1 mg/kg
Administration:IP, single
Result:Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.

IC 50

μ Opioid Receptor/MOR: 3.5 nM (IC50); δ Opioid Receptor/DOR: 4500 nM (IC50)

storage

Store at -20°C

CTAP Preparation Products And Raw materials

Raw materials

Preparation Products

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CTAP Suppliers

China 112 Europe 1 Germany 3 Switzerland 1 United Kingdom 1 United States 14 USA 1 Global 133
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from CTAP manufacturers

Career Henan Chemical Co
Product
CTAP 103429-32-9
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

103429-32-9, CTAPRelated Search:

Bithionol ANTI-HUMAN CTAP-III PRECURSOR BIOTINYLATED ANTI-HUMAN CTAP-III PRECURSOR HUMAN CTAP-III PRECURSOR CTAP, Tca(1)- CTOP CTAP

  • H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
  • D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
  • CTAP
  • CYS2, TYR3, ARG5, PEN7-AMIDE
  • H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7)
  • CTAP, ≥95%
  • 7)-disulfide
  • M.W. 1104.30 C51H69N13O11S2
  • CTAP-NH2
  • D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH2
  • D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2(DISULFIDE BRIDGE:CYS2-PEN7)
  • CTAP,CTA
  • L-Threoninamide,D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-,cyclic (2&reg
  • D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide cyclic (2-7)-disulfide
  • H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7)
  • L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide
  • H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH? (Disulfide bond between Cys? and Pen?)
  • CTAP, mu opioid antagonist
  • 103429-32-9
  • C51H67N13O11S
  • C51H69N13O11S2
  • Neuropeptides
  • Opioid Peptides
  • Other Opioid Peptides
  • Other Opioid PeptidesPeptides for Cell Biology
  • Opioid receptor and opioid-like receptor
  • Peptide