ChemicalBook > CAS DataBase List > CTOP

CTOP

Product Name
CTOP
CAS No.
103429-31-8
Chemical Name
CTOP
Synonyms
NTB;CTOP;NALTRIBEN;threoninamide;CYS2,TYR3,ORN5,PEN7-AMIDE;M.W. 1062.26 C50H67N11O11S2;(Tyr3,Orn5,Pen7)-Octreotate amide;Cys2, Tyr3, Orn5, Pen7 amide - CTOP;CTOP, mu opioid receptor antagonist;DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
CBNumber
CB9260913
Molecular Formula
C50H67N11O11S2
Formula Weight
1062.26
MOL File
103429-31-8.mol
More
Less

CTOP Property

Boiling point:
1491.2±65.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
RTECS 
XO8578200
storage temp. 
-20°C
pka
9.90±0.15(Predicted)
form 
Powder
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
{D-Phe}-Cys-Tyr-{D-Trp}-{Orn}-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5296
Product name
CTOP
Purity
≥97% (HPLC)
Packaging
1mg
Price
$282
Updated
2025/07/31
Tocris
Product number
1578
Product name
CTOP
Packaging
1
Price
$195
Updated
2021/12/16
TRC
Product number
C800010
Product name
CTOP
Packaging
1mg
Price
$195
Updated
2021/12/16
Usbiological
Product number
460531
Product name
Naltriben
Packaging
1mg
Price
$403
Updated
2021/12/16
ApexBio Technology
Product number
B5135
Product name
CTOP
Packaging
1mg
Price
$282
Updated
2021/12/16
More
Less

CTOP Chemical Properties,Usage,Production

Uses

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.

Uses

CTOP has been used:

  • to study the anxiogenic effects induced by CTOP in mice and rat.
  • to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
  • to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

General Description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Biochem/physiol Actions

Selective ligand for μ-opioid receptors.

in vivo

CTOP (0-0.5 nmol, ICV, once) antagonizes the analgesic effect of morphine in a dose-dependent manner[1].
CTOP (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in morphine-dependent animals[1].
CTOP (0-1.5 nmol per side, Intra-VTA injection) enhances extracellular dopamine levels in the nucleus accumbens and dose-dependently enhances locomotor activity[2].

Animal Model:Male CFLP mice (25-30 g)[1]
Dosage:0, 0.001, 0.05, 0.075, 0.1, and 0.5 nmol (made up in artificial cerebrospinal fluid (CSF) and kept in plastic tubes at -25℃ until use)
Administration:Intracerebroventricular (i.c.v.) administration, once
Result:Antagonized the analgesic effect of morphine in a dose-dependent manner, antagonized the morphine-induced hypermotility in a dose-dependent manner.
Animal Model:Male CFLP mice (25-30 g, Acute dependence to morphine was induced by a single dependence-inducing (100 mg/kg) dose of morphine-HC1)[1]
Dosage:0, 0.001, 0.05, 0.2, and 2 nmol
Administration:Intracerebroventricular (i.c.v.) administration, once
Result:Decreased the body temperature in a dose-dependent manner, and caused withdrawal hypothermia and a loss of body weight in morphine-dependent animals.
Animal Model:Long-Evans hooded rats (12, male, 350-450 g)[2]
Dosage:0, 0.015, 0.15, and 1.5 nmol per side
Administration:Intra-VTA (ventral tegmental area) injection
Result:Enhanced extracellular dopamine levels in the nucleus accumbens, dose-dependently increased activity, whereas had no effect on feeding and drinking behavior.

IC 50

μ Opioid Receptor/MOR

storage

Store at -20°C

CTOP Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CTOP Suppliers

China 96 Europe 1 France 1 Germany 2 Switzerland 1 United Kingdom 2 United States 14 Global 117
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1010
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
More
Less

View Lastest Price from CTOP manufacturers

Career Henan Chemical Co
Product
CTOP 103429-31-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-11

103429-31-8, CTOPRelated Search:

L-Threoninamide monohydrochloride ,L-Threoninamide HCl,L-THREONINAMIDE HYDROCHLORIDE 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2-7)-disulfide N-Carbobenzyloxy-L-threoninamide,N2-(Benzyloxycarbonyl)-L-threoninamide,Z-L-THREONINAMIDE,N-Benzyloxycarbonyl-L-Threoninamide,CBZ-L-THREONINAMIDE isopropyl methyl disulphide L-Penicillamine Z-L-THREONINAMIDE,CBZ-L-THREONINAMIDE CTAP CTOP L-Threoninamide, D-phenylalanyl-L-cycteingyl-L-phenylalanyl-D-tryptoph yl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2-7)-disulfide L-Threoninamide n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide technetium Tc 99m dioxo-1-(alanyl-seryl-threonyl-theonyl-threonyl-asparaginyl-tyrosyl-threoninamide)cyclam phenylalanyl--cysteinyl-tyrosyl-tryptophyl-arginyl-penicillaminyl-threoninamide N-Hydroxy-L-threoninamide phenylalanyl-chlorophenylalanyl-tyrosyl-tryptophyl-lysyl-valyl-phenylalanyl-threoninamide 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide isopropyl propyl disulphide N-octanoyl-asparaginyl-tyrosyl-threoninamide

  • threoninamide
  • NALTRIBEN
  • NTB
  • D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE
  • D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
  • DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
  • CTOP
  • CYS2,TYR3,ORN5,PEN7-AMIDE
  • [CYS2, TYR3, ORN5, PEN7]-SOMATOSTATIN 14 (7-14), AMIDE
  • H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
  • H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 (DISULFIDE BRIDGE: 2-7)
  • FCYW(ORN)T(PEN)T-NH2 (DISULFIDE BRIDGE: 2-7)
  • phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, (Disulfide bond between Cys2 and Pen7)
  • M.W. 1062.26 C50H67N11O11S2
  • D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-3-Mercapto(1)-L-Val-L-Thr-NH2
  • D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-L-Pen(1)-L-Thr-NH2
  • [Cys2, Tyr3, Orn5, Pen7-amide]-Somatostatin 14 (7-14)
  • Cys2, Tyr3, Orn5, Pen7 amide - CTOP
  • CTOP, (Tyr3,Orn5,Pen7)-Octreotate aMide
  • (Tyr3,Orn5,Pen7)-Octreotate amide
  • phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond)
  • L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide
  • Cys2, Tyr3, Orn5, Pen7-NH2]-Somatostatin14(7-14)
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond) TFA Salt
  • CTOP, mu opioid receptor antagonist
  • 103429-31-8
  • C50H67N11O11S2
  • Opioid Peptides
  • Other Opioid Peptides
  • Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • peptide
  • Neuropeptides
  • Opioid Peptides
  • Other Opioid Peptides
  • Other Opioid PeptidesPeptides for Cell Biology
  • Opioid receptor and opioid-like receptor