L-Penicillamine

Product Name: L-Penicillamine
CAS No.: 1113-41-3
Chemical Name: L-Penicillamine
Synonyms: l-valin;H-PEN-OH;3-MERCAPTO-L-VALINE;3,3-DIMETHYL-L-CYSTEINE;L-Pen-OH;L-(+)-B2;NSC 241261;3-Mercapto-;3-THIOL-VALINE;-Penicillamine
CBNumber: CB6302922
Molecular Formula: C5H11NO2S
Formula Weight: 149.21
MOL File: 1113-41-3.mol

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L-Penicillamine Property

Melting point:: 206 °C (dec.)(lit.)
alpha: 61.9 º (C=0.5 IN 1 M NAOH)
Boiling point:: 251.8±35.0 °C(Predicted)
Density: 1.113 (estimate)
refractive index: 63 ° (C=1, 1mol/L NaOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
pka: 2.13±0.12(Predicted)
form: Crystalline Powder
color: White to almost white
optical activity: [α]24/D +61.9°, c = 0.5 in 1 M NaOH
Merck: 14,7088
BRN: 1722374
Stability:: Hygroscopic
InChIKey: VVNCNSJFMMFHPL-GSVOUGTGSA-N
CAS DataBase Reference: 1113-41-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-40-20/21/22
Safety Statements: 26-36-22-24/25
WGK Germany: 2
RTECS: YV9445500
HS Code: 29309090
Toxicity: LD50 i.p. in rats: 350 mg/kg (Jaffe)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 196312
Product name: L-Penicillamine
Purity: 99%
Packaging: 1g
Price: $77.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 196312
Product name: L-Penicillamine
Purity: 99%
Packaging: 5g
Price: $264
Updated: 2024/03/01

TCI Chemical

Product number: P1370
Product name: L-Penicillamine
Purity: >98.0%(T)
Packaging: 1g
Price: $43
Updated: 2021/12/16

TCI Chemical

Product number: P1370
Product name: L-Penicillamine
Purity: >98.0%(T)
Packaging: 5g
Price: $93
Updated: 2021/12/16

Alfa Aesar

Product number: L13923
Product name: L-(+)-Penicillamine, 98+%
Packaging: 250mg
Price: $0
Updated: 2021/12/16

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L-Penicillamine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Uses

L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Uses

Metal-chelating agent

Uses

As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Indications

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.

Definition

ChEBI: The L-enantiomer of penicillamine.

Mechanism of action

The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.

Pharmacology

Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.

Safety Profile

A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.

Purification Methods

Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-Penicillamine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Penicillamine Suppliers

Americas 1 Belgium 1 Canada 1 China 171 Europe 1 France 1 Germany 4 India 8 Japan 3 South Korea 1 Switzerland 2 United Kingdom 3 United States 27 Global 224

MINKESH (SHANGHAI) CO., LTD.

Tel: +86-021-20980300 +86-13167252998
Fax: 021-20983811
Email: sales@minkesh.com
Country: China
ProdList: 76
Advantage: 55

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
ProdList: 8465
Advantage: 55

Jiangsu Shengkang Meixiang Technology Co., Ltd.

Tel: 18217475093
Email: 1615396342@qq.com
Country: China
ProdList: 4309
Advantage: 58

Madision Biomedical Co., Ltd.

Tel: 028-87439248 19150327610
Fax: 028-87439248
Email: 553691721@qq.com
Country: China
ProdList: 62
Advantage: 58

Shanghai Jifeng Biotechnology Co., Ltd.

Tel: 021-61263377 15023907684
Fax: 021-61263399
Email: 15800684150@163.com
Country: China
ProdList: 8131
Advantage: 58

CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.

Tel: 86-13062552990 13062552990
Email: sales@aldone.com.cn
Country: China
ProdList: 135
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

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View Lastest Price from L-Penicillamine manufacturers

Henan Fengda Chemical Co., Ltd

Product: L-Penicillamine 1113-41-3
Price: US $8.00-3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

PNP Biotech Co. Ltd

Product: L-penicillamine 1113-41-3
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-09-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-Penicillamine 1113-41-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

1113-41-3, L-PenicillamineRelated Search:

L-Valine POTASSIUM THIOGLYCOLATE Mercaptoacetic acid 2-Ethylhexyl mercaptoacetate 6-Mercaptopurine 3-Mercaptopropionic acid Calcium thioglycolate (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Sodium thioglycolate 3-mercapto-L-valine hydrochloride 3-(4-acetylphenyl)-2-aminopropanoic acid hydrochloride 3-METHOXY-L-PHENYLALANINE (S)-2-AMino-3-(3-iodophenyl)propanoic acid 3-Methylphenyl-L-alanine L-3-Chlorophenylalanine L-3-Cyanophenylalanine 2-Chloro-L-phenylalanine L-2-Bromophenylalanine

3-MERCAPTO-L-VALINE

3-THIOL-VALINE

3,3-DIMETHYL-L-CYSTEINE

TIMTEC-BB SBB000102

L-BETA,BETA-DIMETHYLCYSTEINE

L-BETA-MERCAPTOVALINE

L-(+)-PENICILLAMINE

L-PENICILLAMINE

L(+)-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID

H-BETA,BETA-DIMETHYL-CYS-OH

H-CYS(3-ME 2)-OH

H-PEN-OH

BETA,BETA-DIMETHYL-L-CYSTEINE

PENICILLAMINE(L-)

<small>L</small>-Penicillamine

L-Penicillamine≥ 99.0% (Titration: anhydrous basis)

Penicillamine Impurity 4(L-Penicillamine)

(2R)-2-amino-3-methyl-3-sulfanylbutanoic acid

3-mercapto-l-valin

L-(+)-PENICILLAMINE, 98+%

L-PENICILLAMINE 99.5+%

3,3-Dimethyl-L-cysteine~3-Mercapto-L-valine

(R)-Penicillamine

L-Valine, 3-mercapto- (9CI)

NSC 241261

Valine, 3-mercapto-, L- (8CI)

l-valin

3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid

3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid β,β-Dimethyl-L-cysteine

[R,(+)]-2-Amino-3-mercapto-3-methylbutyric acid

L-(+)-β-mercaptovaline

3-Mercapto-

L-PenicillaMine-d6

L-beta,beta-Dimethylcysteine L-beta-Mercaptovaline

H-b,b-DiMethyl-Cys-OH, H-b-Mercapto-Val-OH

L-Pen-OH

L-PenicillaMine 99%

L-Penicillamine&gt

L-Valine, 3-mercapto-

L-Penicillamine ISO 9001：2015 REACH

L-(+)-B2

-mercaptovaline

3-Sulfanyl-L-Valine

L-(+)-β-mercaptovaline

-Penicillamine

L-PENCILLAMINE

1113-41-3

AMINE

Specialty Synthesis

Peptide Synthesis

Unnatural Amino Acid Derivatives

Amino Acids & Derivatives

Intermediates & Fine Chemicals

Pharmaceuticals

Amino Acids

Biochemistry

non-Proteinorganic Amino Acids

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