Lanreotide
Description Background- Product Name
- Lanreotide
- CAS No.
- 108736-35-2
- Chemical Name
- Lanreotide
- Synonyms
- IPSTYL;AUTOGEL;DC-13-116;BIM-23014;LANREOTIDE;bim-23014c;Somatuline;ANGIOPEPTIN;LaroMustine;D8-Lanreotide
- CBNumber
- CB6190280
- Molecular Formula
- C54H69N11O10S2
- Formula Weight
- 1096.32
- MOL File
- 108736-35-2.mol
Lanreotide Property
- Boiling point:
- 1508.2±65.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- pka
- 9.90±0.15(Predicted)
- Sequence
- D-2-Nal-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2
- InChIKey
- PUDHBTGHUJUUFI-VHAAONQQNA-N
Safety
- WGK Germany
- 3
- HS Code
- 3504009000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- L1275
- Product name
- Lanreotide
- Packaging
- 200ug
- Price
- $297
- Updated
- 2021/12/16
- Product number
- CM100725
- Product name
- Lanreotide acetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $729
- Updated
- 2021/12/16
- Product number
- CD22005163
- Product name
- Lanreotide
- Purity
- 97%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CD22005163
- Product name
- Lanreotide
- Purity
- 97%
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
Lanreotide Chemical Properties,Usage,Production
Description
Lanreotide is a synthetic octapeptide analogue of somatostatin with enhanced metabolic stability compared with somatostatin. It binds with high affinity to and stimulates the somatostatin receptors SSTR2 and SSTR5, with relatively greater potency at SSTR2 and very low binding to SSTR1, SSTR3 and SSTR4. It is used to treat acromegaly and neuroendocrine tumors.
Chemical Properties
White to off-white lyophilised powder
Uses
Antineoplas tic.
Side effects
Lanreotide depot was generally well tolerated, as 88% of patients had adverse events, compared with the placebo at 90%. Most adverse events were mild (17%) or moderate (44%) in both lanreotide and placebo groups. The most common adverse event was diarrhea at 26% in the lanreotide group and 9% with placebo. Abdominal pain was recorded in 14% of patients taking lanreotide but only occurred in 2% of patients taking placebo. Cholelithiasis occurred in 10% of patients but only 3% in the placebo group. Hyperglycemia occurred in 5% of lanreotide patients but was not observed in placebo patients.
in vivo
Lanreotide (2.5-10mg/kg; s.c.; daily for 5 days) results in tumor growth inhibition[1].
| Animal Model: | Male nude mice, 8 weeks old and 20–25?g in body weight (GH3 tumor-bearing nude mice)[1] |
| Dosage: | 2.5, 5, 10?mg/kg |
| Administration: | Subcutaneous; daily for 5 days |
| Result: | Produced tumor growth inhibition. |
Description
Lanreotide is an octapeptide, an analogue of a naturally occurring hormone, somatostatin.
Background
Lanreotide is a peptide inhibitor of a number of endocrine, neuroendocrine, exocrine and paracrine functions. It shows good affinity for peripheral somatostatin receptors (anterior pituitary and pancreatic). In contrast, its affinity for central receptors is much lower. This profile confers a good specificity of action at the level of growth hormone and digestive hormone secretion. Lanreotide shows a much longer duration of action than natural somatostatin. In addition, its marked selectivity for the secretion of growth hormone, compared to that of insulin, makes it a suitable candidate for the treatment of acromegaly. By inhibiting the synthesis of thyroid stimulating hormone (TSH), lanreotide also normalised thyroid function of patients with thyrotrophin secreting adenomas in 50% (8/16) of the per-protocol population treated for 6 months. There was no significant reduction in the size of the adenoma. Furthermore, the inhibitory action of lanreotide on intestinal exocrine secretion, d
Lanreotide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Lanreotide manufacturers
- Product
- Lanreotide 108736-35-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2023-01-12
- Product
- Lanreotide 108736-35-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- Lanreotide 108736-35-2
- Price
- US $60.00/g
- Min. Order
- 1g
- Purity
- 0.99
- Supply Ability
- 100000kgs
- Release date
- 2023-11-02