Lixisenatide

Product Name: Lixisenatide
CAS No.: 320367-13-3
Chemical Name: Lixisenatide
Synonyms: Lyxumia;lixisenatide;Lixisenatide, >98%;Lixisenatide Acetate;Lixisenatide USP/EP/BP;Lixisenatide|Lixisenatide Acetate
CBNumber: CB01518519
Molecular Formula: C215H347N61O65S
Formula Weight: 4858.53
MOL File: 320367-13-3.mol

More

Less

Lixisenatide Property

storage temp.: Store at -20°C
solubility: Water:103.0(Max Conc. mg/mL);21.2(Max Conc. mM)
Sequence: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2
InChI: InChI=1/C215H347N61O65S/c1-16-115(10)173(210(337)256-141(68-74-170(299)300)194(321)261-148(94-122-98-232-126-50-24-23-49-124(122)126)199(326)258-143(89-111(2)3)196(323)247-134(58-32-40-83-223)189(316)262-149(96-160(226)285)180(307)235-100-161(286)233-104-165(290)274-85-42-60-156(274)207(334)267-154(108-280)206(333)265-151(105-277)181(308)237-101-162(287)239-117(12)213(340)276-87-44-62-158(276)214(341)275-86-43-61-157(275)208(335)268-153(107-279)204(331)249-132(56-30-38-81-221)187(314)246-131(55-29-37-80-220)186(313)245-130(54-28-36-79-219)185(312)244-129(53-27-35-78-218)184(311)243-128(52-26-34-77-217)183(310)242-127(176(227)303)51-25-33-76-216)272-201(328)146(92-120-45-19-17-20-46-120)260-197(324)144(90-112(4)5)257-190(317)135(59-41-84-231-215(228)229)255-209(336)172(114(8)9)271-177(304)116(11)240-182(309)138(65-71-167(293)294)251-192(319)139(66-72-168(295)296)252-193(320)140(67-73-169(297)298)253-195(322)142(75-88-342-15)254-191(318)137(63-69-159(225)284)250-188(315)133(57-31-39-82-222)248-203(330)152(106-278)266-198(325)145(91-113(6)7)259-200(327)150(97-171(301)302)263-205(332)155(109-281)269-212(339)175(119(14)283)273-202(329)147(93-121-47-21-18-22-48-121)264-211(338)174(118(13)282)270-164(289)103-236-179(306)136(64-70-166(291)292)241-163(288)102-234-178(305)125(224)95-123-99-230-110-238-123/h17-24,45-50,98-99,110-119,125,127-158,172-175,232,277-283H,16,25-44,51-97,100-109,216-224H2,1-15H3,(H2,225,284)(H2,226,285)(H2,227,303)(H,230,238)(H,233,286)(H,234,305)(H,235,307)(H,236,306)(H,237,308)(H,239,287)(H,240,309)(H,241,288)(H,242,310)(H,243,311)(H,244,312)(H,245,313)(H,246,314)(H,247,323)(H,248,330)(H,249,331)(H,250,315)(H,251,319)(H,252,320)(H,253,322)(H,254,318)(H,255,336)(H,256,337)(H,257,317)(H,258,326)(H,259,327)(H,260,324)(H,261,321)(H,262,316)(H,263,332)(H,264,338)(H,265,333)(H,266,325)(H,267,334)(H,268,335)(H,269,339)(H,270,289)(H,271,304)(H,272,328)(H,273,329)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H4,228,229,231)/t115-,116-,117-,118+,119+,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,172-,173-,174-,175-/s3
InChIKey: XVVOERDUTLJJHN-JXBMKTOPNA-N
SMILES: N([C@H](C(N[C@H](C(=O)N[C@@H](CCCCN)C(N[C@H](C(=O)N)CCCCN)=O)CCCCN)=O)CCCCN)C(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC([C@H]1N(CCC1)C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2C=CC=CC1=2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC1N=CNC=1)N)CO)CCSC)CCC(=O)O)CCC(O)=O)CCC(=O)O)[C@@H](C)CC)=O)CCCCN |&1:1,4,8,16,39,43,52,58,65,72,81,87,92,107,115,124,132,146,155,159,170,178,189,196,201,205,209,213,217,226,235,241,249,257,261,262,268,279,280,290,303,332,r|
CAS DataBase Reference: 320367-13-3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-5788
Product name: Lixisenatide
Packaging: 1mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-5788
Product name: Lixisenatide
Packaging: 2mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-5788
Product name: Lixisenatide
Packaging: 5mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-5788
Product name: Lixisenatide
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611442
Product name: Lixisenatide
Packaging: 5mg
Price: $805.8
Updated: 2021/12/16

More

Less

Lixisenatide Chemical Properties,Usage,Production

Description

Lixisenatide injection is used to treat type 2 diabetes mellitus. Lixisenatide is used together with diet and exercise to help control your blood sugar. This medicine is a glucagon-like peptide-1 (GLP-1) receptor agonist.

History

Lixisenatide (brand name Lyxumia), has been available since 2013 in many other countries. It is now the fifth GLP-1 receptor agonist to be approved in the United States.

Uses

Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

Definition

ChEBI: Lixisenatide is a forty-four membered polypeptide consisting of L-His, Gly, L-Glu, Gly, L-Thr, L-Phe, L-Thr, L-Ser, L-Asp, L-Leu, L-Ser, L-Lys, L-Gln, L-Met, L-Glu, L-Glu, L-Glu, L-Ala, L-Val, L-Arg, L-Leu, L-Phe, L-Ile, L-Glu, L-Trp, L-Leu, L-Lys, L-Asn, Gly, Gly, LPro, L-Ser, L-Ser, Gly, L-Ala, L-Pro, L-Pro, L-Ser, L-Lys, L-Lys, L-Lys, L-Lys, L-Lys, and L-Lys-NH2 residues joined in sequence. Used as an adjunct to diet and exercise for the treatment of adults with type II diabetes. It has a role as a glucagon-like peptide-1 receptor agonist, a hypoglycemic agent and a neuroprotective agent. It is a polypeptide and a peptidyl amide.

Indications

Both Adlyxin and Soliqua 100/33 are FDA-approved as adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Soliqua 100/33 is indicated specifically in those inadequately controlled on basal insulin (less than 60 units daily) or lixisenatide.

Mechanism of action

Lixisenatide is a GLP-1 receptor agonist that works by increasing glucose-dependent insulin release, decreasing glucagon secretion, and slowing gastric emptying.Insulin glargine works through regulation of glucose metabolism. Specifically, insulin lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.

Pharmacology

Lixisenatide acts as an agonist at the GLP-1 receptor. In the pancreas, this agonism results in increased glucose-stimulated insulin exocytosis by beta islet cells. This produces a reduction in blood glucose due to increased glucose uptake by tissues 1. GLP-1 receptor activation in the GI tract results in delayed gastric emptying which is thought to mediate the effects of lixisenatide on postprandial blood glucose.

Safety

The most common adverse reactions associated with lixisenatide during clinical trials were hypoglycemia, allergic reactions, nausea, nasopharyngitis, upper respiratory tract infection, and headache.

Lixisenatide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Lixisenatide Suppliers

China 124 India 1 United States 8 Global 133

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921 13355716090
Email: Sales@gotopbio.com
Country: China
ProdList: 2831
Advantage: 58

Apextide Co Ltd

Tel: 15700198315
Email: shubin.zhao@apextide.com
Country: China
ProdList: 73
Advantage: 58

Linyi Shengyuan Biotechnology Co., LTD

Tel: 18315779352
Email: 1904618300@qq.com
Country: China
ProdList: 35
Advantage: 58

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Fuhe Chemistry Technology Co., Ltd.

Tel: 0086-21-67651709
Fax: 0086-21-67651705
Email: cfx759@hotmail.com
Country: China
ProdList: 410
Advantage: 57

Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd

Tel: 010-53679529 13801208576
Fax: 010-64215766
Email: sales.2@chinazhongshuo.com
Country: China
ProdList: 97
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

More

Less

View Lastest Price from Lixisenatide manufacturers

Shanghai Getian Industrial Co., LTD

Product: Lixisenatide 320367-13-3
Price: US $20.00-18.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000box
Release date: 2024-04-18

Nantong Guangyuan Chemicl Co,Ltd

Product: Lixisenatide 320367-13-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-15

Henan Tengmao Chemical Technology Co. LTD

Product: Lixisenatide 320367-13-3
Price: US $110.00-90.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 500tons
Release date: 2023-11-09

320367-13-3, LixisenatideRelated Search:

Angiotensin acetate Nafarelin Lypressin Gonadorelin acetate GLP-1 (7-37) Angiotensin acetate Deslorelin Taspoglutide Semaglutide Exendin-4 Albiglutide Liraglutide Cetrorelix acetate Glucagon Lanreotide Degarelix Exenatide acetate Goserelin

Lixisenatide, >98%

lixisenatide

Lixisenatide|Lixisenatide Acetate

Lixisenatide Acetate

Lixisenatide USP/EP/BP

Lyxumia

320367-13-3

C215H347N61O65S