Semaglutide
Discovery Description- Product Name
- Semaglutide
- CAS No.
- 910463-68-2
- Chemical Name
- Semaglutide
- Synonyms
- semaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;Sermaglutide CAS 910463 68 2;OG217SC;Somaroutin;Somalutide;semgalutide;Somaglutide;Somarlutide
- CBNumber
- CB93069423
- Molecular Formula
- C187H291N45O59
- Formula Weight
- 4113.57754
- MOL File
- 910463-68-2.mol
Semaglutide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO：3mg/mL (0.73 mM)
- form
- Solid
- color
- White to off-white
- InChIKey
- DLSWIYLPEUIQAV-CCUURXOWSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FS171058
- Product name
- Semaglutide
- Packaging
- 10mg
- Price
- $37.5
- Updated
- 2021/12/16
- Product number
- AG-CP3-0040-M001
- Product name
- Semaglutide
- Purity
- ≥98%(HPLC)
- Packaging
- 1mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0069903
- Product name
- Semaglutide
- Purity
- 99.84%
- Packaging
- 500ug
- Price
- $160
- Updated
- 2021/12/16
- Product number
- AG-CP3-0040-M005
- Product name
- Semaglutide
- Purity
- ≥98%(HPLC)
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0069903
- Product name
- Semaglutide
- Purity
- 99.84%
- Packaging
- 1mg
- Price
- $260
- Updated
- 2021/12/16
Semaglutide Chemical Properties,Usage,Production
Discovery
Semaglutide, developed by Novo Nordisk and marketed under the brand name Ozempic, is a glucagon-like peptide-1 (GLP-1) analogue. This injectable form was first approved by the FDA in December 2017 for the treatment of type 2 diabetes, reducing the risk of major cardiovascular events in patients with type 2 diabetes and cardiovascular disease, and reducing the risk of kidney disease progression and cardiovascular death in patients with type 2 diabetes and chronic kidney disease. In September 2019, Semaglutide was further approved by the FDA in tablet form under the brand name Rybelsus for the treatment of type 2 diabetes and for reducing cardiovascular (CV) risk in high-risk adults with type 2 diabetes. By March 2024, the FDA approved Semaglutide injection (Wegovy) as the first drug to reduce the risk of serious heart disease in obese or overweight adults.
Description
Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as Ozempic, Wegovy, and Rybelsus. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.
History
The story of semaglutide began in the 1980s when scientists (such as Joel Habener and Jens Juul Holst) discovered GLP-1, a hormone in the human body that regulates blood sugar and appetite. However, its highly degradable nature limited its potential for medicinal use. In the 1990s, researchers at Novo Nordisk in Denmark, including Lotte Bjerre Knudsen, drew inspiration from the Gila monster's venom protein Exendin-4 and successfully developed the first GLP-1 drug, exenatide. In pursuit of a longer-acting drug, the Novo Nordisk team, led by Knudsen, created a once-daily liraglutide in the 2000s by structurally modifying human GLP-1 and adding fatty acid chains. Building on this success, the team further optimized the formula, ultimately leading to the development of semaglutide, with a longer half-life, by scientists including a research team led by Mads Krogsgaard Thomsen. It was approved in 2017 as a once-weekly blood sugar lowering drug (Ozempic), and in 2021 it shocked the world with its remarkable effects in the field of weight loss (Wegovy), evolving from a scientific concept into a benchmark drug that changes the treatment of metabolic diseases.
Uses
Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.
Definition
ChEBI: Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a glucagon-like peptide-1 receptor agonist, an anti-obesity agent, a neuroprotective agent and an appetite depressant. It is a polypeptide and a lipopeptide.
Biological Activity
Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
Mechanism of action
Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of insulin, a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production. It also inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.
Pharmacokinetics
Median tmax,semaglutide was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL. AUC0-24h,semaglutide and Cmax,semaglutide were approximately 70% higher when dosed with 50 versus 240 mL water[2].
Side effects
Some common side effects of Semaglutide include: nausea, vomiting, diarrhea, abdominal pain, and constipation may occur.
Less common but serious side effects of Semaglutide include: kidney problems, diabetic retinopathy, allergic reactions, low blood sugar, and pancreatitis.
In people with heart problems, it can cause damage to the back of the eye (retinopathy). If you experience any of these serious side effects, contact your healthcare provider immediately.
www.mayoclinic.org
in vitro
Semaglutide is selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) is three-fold decreased compared to liraglutide, whereas the albumin affinity is increased.
in vivo
The plasma half-life is 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs.
Metabolism
Intact semaglutide was the primary component circulating in plasma for humans and both nonclinical species, accounting for 69–83% of the total amount of semaglutide-related material, and was metabolised prior to excretion. Recovery of excreted radioactivity was 75.1% in humans, 72.1% in rats and 58.2% in monkeys. Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals[1]. Semaglutide was metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain, and metabolism was not confined to specific organs. Intact semaglutide in urine accounted for 3.1% of the administered dose in humans and less than 1% in rats; it was not detected in urine in monkeys.
Description
Semaglutide Synthetic is a single, non-glycosylated polypeptide chain containing 31 amino acids, having a molecular mass of 4113 Dalton and a Molecular formula of C187H291N45O59.
Precautions
The FDA recommends Wegovy for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol; Have a BMI of 30kg/m2 or greater.
Avoid semaglutide if you have: History of medullary thyroid cancer; History of gallbladder disease; History of pancreatitis; Multiple endocrine neoplasia syndrome type 2 (MEN2).
References
[1] A, Lene Jensen , et al. "Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species." European Journal of Pharmaceutical Sciences 104(2017):31-41.
[2] Tine A. B?kdal. “Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study.” Clinical Pharmacology in Drug Development 10 5 (2021): 453–462.
Semaglutide Preparation Products And Raw materials
Raw materials
Preparation Products
Semaglutide Suppliers
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View Lastest Price from Semaglutide manufacturers
- Product
- Semaglutide 10mg 910463-68-2
- Price
- US $10.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 1000Kilogram/Month
- Release date
- 2025-11-20
- Product
- Semaglutide 910463-68-2
- Price
- US $5.00-0.50/Gram
- Min. Order
- 1Gram
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-11-20
- Product
- Semaglutide 910463-68-2
- Price
- US $5.00-0.50/Gram
- Min. Order
- 1Gram
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-11-20