Description References
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Desmopressin

Description References
Product Name
Desmopressin
CAS No.
16679-58-6
Chemical Name
Desmopressin
Synonyms
DDAVP;MINIRIN;esmopressin;DESMOPRESSIN;DDAVP, HUMAN;[deamino-Cys;Desmopressin CRS;DESMOPRESSIN, HUMAN;Iloprost Impurity 8;Desmopressin (DDAVP)
CBNumber
CB5487392
Molecular Formula
C46H64N14O12S2
Formula Weight
1069.22
MOL File
16679-58-6.mol
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Desmopressin Property

alpha 
D25 +85.5 ± 2° (calculated for the free peptide)
Density 
1.56±0.1 g/cm3(Predicted)
RTECS 
YW9000000
storage temp. 
Store at 0°C
solubility 
H2O: soluble20mg/mL, clear, colorless
pka
9.90±0.15(Predicted)
Water Solubility 
Soluble to 4 mg/ml in water
InChIKey
NFLWUMRGJYTJIN-PNIOQBSNSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V1005
Product name
[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
Purity
≥95%(HPLC)
Packaging
0.1mg
Price
$80.4
Updated
2024/03/01
Sigma-Aldrich
Product number
V1005
Product name
[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
Purity
≥95%(HPLC)
Packaging
0.5mg
Price
$246
Updated
2024/03/01
Alfa Aesar
Product number
J66929
Product name
[Deamino-Cys<sup>1</sup>, Arg<sup>8</sup>] Vasopressin
Packaging
1mg
Price
$92.7
Updated
2021/12/16
Cayman Chemical
Product number
17348
Product name
Desmopressin
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17348
Product name
Desmopressin
Purity
≥95%
Packaging
1mg
Price
$74
Updated
2024/03/01
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Desmopressin Chemical Properties,Usage,Production

Description

Desmopressin (Brand name: DDAVP) is an artificial derivative of vasopressin, being similar to the antidiuretic hormone (ADH) that naturally produced in the body. It is used for the treatment of diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease and high blood urea levels. It is capable of increasing the water permeability in the renal tubular cells, further increasing the urine concentration and decreasing the urine production. Therefore, it can be used to prevent and control severe thirst, urination and dehydration caused by various kinds of reasons including injury, surgery and certain medical condition. This help you sleep throughout the night without being awaken by urinate.

References

https://www.drugbank.ca/drugs/DB00035
http://www.medicinenet.com/desmopressin_tabs/article.htm
https://en.wikipedia.org/wiki/Desmopressin

Chemical Properties

White or almost white, fluffy powder.

Originator

DAV,Ritter,Switz.,1974

Uses

Antidiuretic.

Uses

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.

Definition

ChEBI: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine prod ction, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial iabetes insipidus and in tests of renal function.

Manufacturing Process

β-Benzylmercaptopropionyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-L-prolyl-NG-tosyl-D-arginyl-glycinamide (0.5 g) is reduced with sodium in liquid ammonia. The liquid ammonia is then evaporated and the residue dissolved in 5% aqueous acetic acid (800 ml). The solution is filtered to remove the undissolved portion and the filtrate is adjusted to a pH of 6.5 to 7 by addition of aqueous sodium hydroxide and it is then oxidized by known procedure, cf. Kimbrough, R.D., Jr.; Cash, W.D.; Branda, L.A.; Chan, W.Y.; and Du Vigneaud, V.; J. Biol. Chem. 238,1411 (1963). The reaction mixture is thereupon adjusted to a pH of 4 to 4.5 by addition of acetic acid. The peptide is applied to a column of a carboxylate ion exchange resin, is eluted with 50% aqueous acetic acid and isolated by lyophilization (freeze-drying). The crude product is purified by known procedure using a carrier-free high-voltage electrophoresis, cf. Zaoral, M.; Sorm, F.; Collection Czechoslov. Chem Communs, 31, 310 (1966). Yield, 100 to 200 mg of 1-deamino-8-D-argine-vasopressin.

brand name

Concentraid (Ferring Pharmaceuticals); Ddavp (Sanofi Aventis); Stimate (ZLB Behring).

Therapeutic Function

Antidiuretic

Biochem/physiol Actions

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.

Clinical Use

Diabetes insipidus
Nocturnal enuresis
Nocturia due to idiopathic nocturnal polyuria
Post-biopsy bleeding (unlicensed indication)
Pre-biopsy prophylaxis (unlicensed indication)

Metabolism

Metabolic fate of desmopressin is unknown. It is not affected by liver microsomal cytochrome P450 enzymes. As a peptide, desmopressin is expected to undergo catabolism to its constituent amino acids, with subsequent recycling of the amino acid in the body pool.

storage

Store at -20°C

Desmopressin Preparation Products And Raw materials

Raw materials

Preparation Products

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Desmopressin Suppliers

Hangzhou Peptide Biochem Co.,Ltd
Tel
0571-89197072; 18668118770
Fax
0571-89197072
Email
linda@peptide-china.com
Country
China
ProdList
248
Advantage
56
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Hangzhou nuotong biotechnology co. LTD
Tel
0571-88589737 18506821783
Email
xiaozhi.xu@sinopep.com
Country
China
ProdList
87
Advantage
58
Shenzhen JYMed Technology Co., Ltd.
Tel
755-755-26612112 15013529272;
Fax
+86 (755) 8635-0488
Email
jymed@jymedtech.com
Country
China
ProdList
81
Advantage
58
Phygene
Tel
18059081430
Email
2070812664@qq.com
Country
China
ProdList
1232
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
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View Lastest Price from Desmopressin manufacturers

Hangzhou Hyper Chemicals Limited
Product
Desmopressin 16679-58-6
Price
US $0.00-0.00/Gram
Min. Order
1Gram
Purity
98%
Supply Ability
50KG
Release date
2024-04-30
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Desmopressin 16679-58-6
Price
US $70.00-700.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-27
Shanghai Yunao International Trade Co., Ltd
Product
(Deamino-Cys1,D-Arg8)-Vasopressin acetate salt 16679-58-6
Price
US $30.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
2000
Release date
2023-10-11

16679-58-6, DesmopressinRelated Search:


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