tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
- Product Name
- tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
- CAS No.
- 1118767-16-0
- Chemical Name
- tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
- Synonyms
- tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu;Semaglutide side chain;(S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid;Side chain;Semaglutide linker;Carbaryl Impurity 3;Egf(a) analogue-13C4;Somaluptide side chain;Semaglutide impurity 22;tBuO-Ste-Glu(AEEA-AEEA)-OtBu
- CBNumber
- CB43975343
- Molecular Formula
- C43H79N3O13
- Formula Weight
- 846.1
- MOL File
- 1118767-16-0.mol
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Property
- Boiling point:
- 940.6±65.0 °C(Predicted)
- Density
- 1.079±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place, Sealed in dry, Store in freezer, under -20°C
- solubility
- Ethanol: Slightly soluble: 0.1-1 mg/ml
- form
- Solid
- pka
- 3.39±0.10(Predicted)
- color
- White to off-white
- InChIKey
- YZUXNRZPWYRMGH-DHUJRADRSA-N
- SMILES
- C(O)(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(OC(C)(C)C)=O)NC(=O)CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 181927
- Product name
- Octa(OtBu)-Glu(AEEA-AEEA-OH)-OtBu
- Packaging
- 1g
- Price
- $800
- Updated
- 2021/12/16
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Chemical Properties,Usage,Production
Description
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is the 18-carbon fatty acid side chain of somatostatin, which contributes to an increased affinity for albumin (approximately 5-6 fold). Somalutide is a glucagon-like peptide-1 (GLP-1) analogue with hypoglycaemic properties.
Uses
(S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.
Definition
TBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is also known as Semaglutide Side Chain. An 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.
Application
OLED intermediates, Pharmaceutical Raw Intermediates, Fine Chemical Intermediate
References
[1] IVAN GURYANOV*. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide[J]. Organic Process Research & Development, 2021, 25 7: 1598-1611. DOI: 10.1021/acs.oprd.1c00021
[2] THOMAS B. KJELDSEN. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320[J]. Journal of Medicinal Chemistry, 2020, 64 1: 616-628. DOI: 10.1021/acs.jmedchem.0c01576
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Preparation Products And Raw materials
Raw materials
Preparation Products
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Suppliers
- Tel
- 189-75832125 13397510867
- BD@csmspharm.com
- Country
- China
- ProdList
- 399
- Advantage
- 58
- Tel
- +86-028-82550498 +86-19102685862
- Fax
- 086-28-82550468
- sales@pu-kang.com
- Country
- China
- ProdList
- 497
- Advantage
- 58
- Tel
- 0576-0576-89232655 13566878689
- Fax
- 0576-88860891
- info@seasonsbio.com
- Country
- China
- ProdList
- 37
- Advantage
- 58
- Tel
- 19983060238
- sales@tachem.cn
- Country
- China
- ProdList
- 103
- Advantage
- 58
- Tel
- 0556-05565032870 13770767175
- liangzhi.xu@nuoquanpharm.com
- Country
- China
- ProdList
- 24
- Advantage
- 58
- Tel
- 18615688519
- Fax
- qq 2477717102
- Sales@h2opharm.com
- Country
- China
- ProdList
- 253
- Advantage
- 58
- Tel
- 0513-82206272 17706270880
- 2057095228@qq.com
- Country
- China
- ProdList
- 173
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1002
- Advantage
- 58
- Tel
- 18963498209
- sales@h2opharm.com
- Country
- China
- ProdList
- 284
- Advantage
- 58
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
View Lastest Price from tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu manufacturers
- Product
- tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu 1118767-16-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-09-22
- Product
- (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid 1118767-16-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 1
- Release date
- 2021-07-06
- Product
- tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu 1118767-16-0
- Price
- US $2.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15