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CTOP

Product Name
CTOP
CAS No.
103429-31-8
Chemical Name
CTOP
Synonyms
NTB;CTOP;NALTRIBEN;threoninamide;CYS2,TYR3,ORN5,PEN7-AMIDE;M.W. 1062.26 C50H67N11O11S2;(Tyr3,Orn5,Pen7)-Octreotate amide;Cys2, Tyr3, Orn5, Pen7 amide - CTOP;DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL;D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
CBNumber
CB9260913
Molecular Formula
C50H67N11O11S2
Formula Weight
1062.26
MOL File
103429-31-8.mol
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CTOP Property

Boiling point:
1491.2±65.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
RTECS 
XO8578200
storage temp. 
-20°C
pka
9.90±0.15(Predicted)
form 
Powder
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5296
Product name
CTOP
Purity
≥97% (HPLC)
Packaging
1mg
Price
$274
Updated
2024/03/01
Alfa Aesar
Product number
J66263
Product name
CTOP
Packaging
1mg
Price
$122
Updated
2021/12/16
Alfa Aesar
Product number
J66263
Product name
CTOP
Packaging
5mg
Price
$441
Updated
2021/12/16
Tocris
Product number
1578
Product name
CTOP
Packaging
1
Price
$195
Updated
2021/12/16
TRC
Product number
C800010
Product name
CTOP
Packaging
1mg
Price
$195
Updated
2021/12/16
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CTOP Chemical Properties,Usage,Production

Uses

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.

Uses

CTOP has been used:

  • to study the anxiogenic effects induced by CTOP in mice and rat.
  • to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
  • to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

General Description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Biochem/physiol Actions

Selective ligand for μ-opioid receptors.

storage

Store at -20°C

CTOP Preparation Products And Raw materials

Raw materials

Preparation Products

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CTOP Suppliers

China 76 Europe 1 France 1 Germany 2 Switzerland 1 United Kingdom 2 United States 13 Global 96
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from CTOP manufacturers

Career Henan Chemical Co
Product
CTOP 103429-31-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-11

103429-31-8, CTOPRelated Search:

L-Threoninamide monohydrochloride ,L-Threoninamide HCl,L-THREONINAMIDE HYDROCHLORIDE 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2-7)-disulfide N-Carbobenzyloxy-L-threoninamide,N2-(Benzyloxycarbonyl)-L-threoninamide,Z-L-THREONINAMIDE,N-Benzyloxycarbonyl-L-Threoninamide,CBZ-L-THREONINAMIDE isopropyl methyl disulphide L-Penicillamine Z-L-THREONINAMIDE,CBZ-L-THREONINAMIDE CTAP CTOP L-Threoninamide, D-phenylalanyl-L-cycteingyl-L-phenylalanyl-D-tryptoph yl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2-7)-disulfide L-Threoninamide n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide technetium Tc 99m dioxo-1-(alanyl-seryl-threonyl-theonyl-threonyl-asparaginyl-tyrosyl-threoninamide)cyclam phenylalanyl--cysteinyl-tyrosyl-tryptophyl-arginyl-penicillaminyl-threoninamide N-Hydroxy-L-threoninamide phenylalanyl-chlorophenylalanyl-tyrosyl-tryptophyl-lysyl-valyl-phenylalanyl-threoninamide 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide isopropyl propyl disulphide N-octanoyl-asparaginyl-tyrosyl-threoninamide

  • threoninamide
  • NALTRIBEN
  • NTB
  • D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE
  • D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
  • DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
  • CTOP
  • CYS2,TYR3,ORN5,PEN7-AMIDE
  • [CYS2, TYR3, ORN5, PEN7]-SOMATOSTATIN 14 (7-14), AMIDE
  • H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
  • H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 (DISULFIDE BRIDGE: 2-7)
  • FCYW(ORN)T(PEN)T-NH2 (DISULFIDE BRIDGE: 2-7)
  • phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, (Disulfide bond between Cys2 and Pen7)
  • M.W. 1062.26 C50H67N11O11S2
  • D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-3-Mercapto(1)-L-Val-L-Thr-NH2
  • D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-L-Pen(1)-L-Thr-NH2
  • [Cys2, Tyr3, Orn5, Pen7-amide]-Somatostatin 14 (7-14)
  • Cys2, Tyr3, Orn5, Pen7 amide - CTOP
  • CTOP, (Tyr3,Orn5,Pen7)-Octreotate aMide
  • (Tyr3,Orn5,Pen7)-Octreotate amide
  • phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond)
  • L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide
  • Cys2, Tyr3, Orn5, Pen7-NH2]-Somatostatin14(7-14)
  • H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond) TFA Salt
  • 103429-31-8
  • C50H67N11O11S2
  • Opioid Peptides
  • Other Opioid Peptides
  • Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • peptide
  • Neuropeptides
  • Opioid Peptides
  • Other Opioid Peptides
  • Other Opioid PeptidesPeptides for Cell Biology
  • Opioid receptor and opioid-like receptor