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CTOP

Product Name: CTOP
CAS No.: 103429-31-8
Chemical Name: CTOP
Synonyms: NTB;CTOP;NALTRIBEN;threoninamide;CYS2,TYR3,ORN5,PEN7-AMIDE;M.W. 1062.26 C50H67N11O11S2;(Tyr3,Orn5,Pen7)-Octreotate amide;Cys2, Tyr3, Orn5, Pen7 amide - CTOP;CTOP, mu opioid receptor antagonist;DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
CBNumber: CB9260913
Molecular Formula: C50H67N11O11S2
Formula Weight: 1062.26
MOL File: 103429-31-8.mol

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CTOP Property

Boiling point:: 1491.2±65.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
RTECS: XO8578200
storage temp.: -20°C
pka: 9.90±0.15(Predicted)
form: Powder
color: white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: {D-Phe}-Cys-Tyr-{D-Trp}-{Orn}-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P5296
Product name: CTOP
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $282
Updated: 2025/07/31

Tocris

Product number: 1578
Product name: CTOP
Packaging: 1
Price: $195
Updated: 2021/12/16

TRC

Product number: C800010
Product name: CTOP
Packaging: 1mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 460531
Product name: Naltriben
Packaging: 1mg
Price: $403
Updated: 2021/12/16

ApexBio Technology

Product number: B5135
Product name: CTOP
Packaging: 1mg
Price: $282
Updated: 2021/12/16

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CTOP Chemical Properties,Usage,Production

Uses

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.

Uses

CTOP has been used:

to study the anxiogenic effects induced by CTOP in mice and rat.
to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

General Description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Biochem/physiol Actions

Selective ligand for μ-opioid receptors.

in vivo

CTOP (0-0.5 nmol, ICV, once) antagonizes the analgesic effect of morphine in a dose-dependent manner^[1].
CTOP (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in morphine-dependent animals^[1].
CTOP (0-1.5 nmol per side, Intra-VTA injection) enhances extracellular dopamine levels in the nucleus accumbens and dose-dependently enhances locomotor activity^[2].

Animal Model:	Male CFLP mice (25-30 g)^[1]
Dosage:	0, 0.001, 0.05, 0.075, 0.1, and 0.5 nmol (made up in artificial cerebrospinal fluid (CSF) and kept in plastic tubes at -25℃ until use)
Administration:	Intracerebroventricular (i.c.v.) administration, once
Result:	Antagonized the analgesic effect of morphine in a dose-dependent manner, antagonized the morphine-induced hypermotility in a dose-dependent manner.

Animal Model:	Male CFLP mice (25-30 g, Acute dependence to morphine was induced by a single dependence-inducing (100 mg/kg) dose of morphine-HC1)^[1]
Dosage:	0, 0.001, 0.05, 0.2, and 2 nmol
Administration:	Intracerebroventricular (i.c.v.) administration, once
Result:	Decreased the body temperature in a dose-dependent manner, and caused withdrawal hypothermia and a loss of body weight in morphine-dependent animals.

Animal Model:	Long-Evans hooded rats (12, male, 350-450 g)^[2]
Dosage:	0, 0.015, 0.15, and 1.5 nmol per side
Administration:	Intra-VTA (ventral tegmental area) injection
Result:	Enhanced extracellular dopamine levels in the nucleus accumbens, dose-dependently increased activity, whereas had no effect on feeding and drinking behavior.

IC 50

μ Opioid Receptor/MOR

storage

Store at -20°C

CTOP Preparation Products And Raw materials

Raw materials

Preparation Products

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CTOP Suppliers

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View Lastest Price from CTOP manufacturers

Career Henan Chemical Co

Product: CTOP 103429-31-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

103429-31-8, CTOPRelated Search:

L-Threoninamide monohydrochloride ,L-Threoninamide HCl,L-THREONINAMIDE HYDROCHLORIDE 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2-7)-disulfide N-Carbobenzyloxy-L-threoninamide,N2-(Benzyloxycarbonyl)-L-threoninamide,Z-L-THREONINAMIDE,N-Benzyloxycarbonyl-L-Threoninamide,CBZ-L-THREONINAMIDE isopropyl methyl disulphide L-Penicillamine Z-L-THREONINAMIDE,CBZ-L-THREONINAMIDE CTAP CTOP L-Threoninamide, D-phenylalanyl-L-cycteingyl-L-phenylalanyl-D-tryptoph yl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2-7)-disulfide L-Threoninamide n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide technetium Tc 99m dioxo-1-(alanyl-seryl-threonyl-theonyl-threonyl-asparaginyl-tyrosyl-threoninamide)cyclam phenylalanyl--cysteinyl-tyrosyl-tryptophyl-arginyl-penicillaminyl-threoninamide N-Hydroxy-L-threoninamide phenylalanyl-chlorophenylalanyl-tyrosyl-tryptophyl-lysyl-valyl-phenylalanyl-threoninamide 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide isopropyl propyl disulphide N-octanoyl-asparaginyl-tyrosyl-threoninamide

threoninamide

NALTRIBEN

NTB

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2

DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL

CTOP

CYS2,TYR3,ORN5,PEN7-AMIDE

[CYS2, TYR3, ORN5, PEN7]-SOMATOSTATIN 14 (7-14), AMIDE

H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2

H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 (DISULFIDE BRIDGE: 2-7)

FCYW(ORN)T(PEN)T-NH2 (DISULFIDE BRIDGE: 2-7)

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide

H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, (Disulfide bond between Cys2 and Pen7)

M.W. 1062.26 C50H67N11O11S2

D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-3-Mercapto(1)-L-Val-L-Thr-NH2

D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-L-Pen(1)-L-Thr-NH2

[Cys2, Tyr3, Orn5, Pen7-amide]-Somatostatin 14 (7-14)

Cys2, Tyr3, Orn5, Pen7 amide - CTOP

CTOP, (Tyr3,Orn5,Pen7)-Octreotate aMide

(Tyr3,Orn5,Pen7)-Octreotate amide

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)

H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond)

L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide

Cys2, Tyr3, Orn5, Pen7-NH2]-Somatostatin14(7-14)

H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond) TFA Salt

CTOP, mu opioid receptor antagonist

103429-31-8

C50H67N11O11S2

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