4-(BROMOMETHYL)PHENYLACETIC ACID
- Product Name
- 4-(BROMOMETHYL)PHENYLACETIC ACID
- CAS No.
- 13737-36-5
- Chemical Name
- 4-(BROMOMETHYL)PHENYLACETIC ACID
- Synonyms
- PAM ACID;BR-PAM-LINKER;4-(Bromomethyl);Loxoprofen Impurity 64;Loxoprofen Impurity 78;LoxLoxoprofen Impurity 64;4-(BroMMethyl)phenylaceticacid;p-(Carboxymethyl)benzyl bromide;4-(CARBOXYMETHYL)BENZYL BROMIDE;P-(BROMOMETHYL)PHENYLACETIC ACID
- CBNumber
- CB1357013
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 13737-36-5.mol
4-(BROMOMETHYL)PHENYLACETIC ACID Property
- Melting point:
- 179-183 °C(lit.)
- Boiling point:
- 343.1±22.0 °C(Predicted)
- Density
- 1.565±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- Crystalline Powder
- pka
- 4.24±0.10(Predicted)
- color
- White to light beige
- BRN
- 2360711
- InChI
- InChI=1S/C9H9BrO2/c10-6-8-3-1-7(2-4-8)5-9(11)12/h1-4H,5-6H2,(H,11,12)
- InChIKey
- WCOCCXZFEJGHTC-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(CBr)C=C1
- CAS DataBase Reference
- 13737-36-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-42
- Safety Statements
- 26-36
- RIDADR
- UN3261
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B1351
- Product name
- 4-(Bromomethyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- B1351
- Product name
- 4-(Bromomethyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- B697438
- Product name
- 4-(Bromomethyl)phenylacetic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B697438
- Product name
- 4-(Bromomethyl)phenylacetic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 00044
- Product name
- 4-(Bromomethyl)phenylacetic acid
- Purity
- 99+%
- Packaging
- 1G
- Price
- $10.4
- Updated
- 2021/12/16
4-(BROMOMETHYL)PHENYLACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to light beige crystalline powder
Uses
4-(Bromomethyl)phenylacetic acid was used as the precursor for serine protease inhibitor. It was also used in the synthesis of a novel crown ether receptor and 4-(acetoxymethyl)phenylacetic acid by reacting with excessive sodium acetate and acetic acid.
Synthesis
622-47-9
13737-36-5
The general procedure for the synthesis of 4-bromomethylphenylacetic acid from p-toluacetic acid was as follows: 24 g of p-toluacetic acid was added to 250 ml of hydrogen trichloride, followed by 75 ml of chlorobenzene as a solvent. To the reaction system, 30 g of N-bromosuccinimide (NBS) and 0.5 g of benzoyl peroxide were added as initiator. Mechanical stirring was turned on and the reaction was heated to 85°C and under incandescent light. The reaction temperature will automatically rise to 110 °C, at which point the reaction temperature needs to be controlled in the range of 90-110 °C. The reaction continues at this temperature for 8 hours, during which the progress of the reaction is monitored by TLC. Upon completion of the reaction, the reaction mixture is cooled and the solid product will precipitate. The solid is collected by filtration and the filter cake is washed with plenty of water. The filter cake was filtered to dryness as much as possible, resulting in 33.7 g of white solid product in 91.9% yield and 99.2% HPLC purity.
References
[1] Patent: CN106905135, 2017, A. Location in patent: Paragraph 0018; 0019; 0020; 0021
[2] Bulletin of the Chemical Society of Japan, 1988, vol. 61, # 7, p. 2467 - 2472
[3] European Journal of Organic Chemistry, 2006, # 18, p. 4135 - 4146
[4] Journal of the Chemical Society, Chemical Communications, 1993, # 4, p. 399 - 401
[5] Patent: EP496548, 1992, A1
4-(BROMOMETHYL)PHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(BROMOMETHYL)PHENYLACETIC ACID manufacturers
- Product
- 4-(BROMOMETHYL)PHENYLACETIC ACID 13737-36-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 4-(BROMOMETHYL)PHENYLACETIC ACID 13737-36-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-(BROMOMETHYL)PHENYLACETIC ACID 13737-36-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24