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2-(4-Bromomethyl)phenylpropionic acid

Product Name
2-(4-Bromomethyl)phenylpropionic acid
CAS No.
111128-12-2
Chemical Name
2-(4-Bromomethyl)phenylpropionic acid
Synonyms
BMPPA;2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID;2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID;Loxoprofen 16;Loxoprofen Impurity 28;Loxoprofen Intermediate;p-Bromomethyl isocyanate;Loxoprofen Sodium intermediate;4-(BROMOMETHYL)HYDRATROPIC ACID;2-[4-(Xiu Jiaji)phenyl]propionate
CBNumber
CB3420139
Molecular Formula
C10H11BrO2
Formula Weight
243.1
MOL File
111128-12-2.mol
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2-(4-Bromomethyl)phenylpropionic acid Property

Melting point:
126-130 °C(lit.)
Boiling point:
148°C (rough estimate)
Density 
1.4557 (rough estimate)
refractive index 
1.5220 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder to crystal
pka
4.29±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C10H11BrO2/c1-7(10(12)13)9-4-2-8(6-11)3-5-9/h2-5,7H,6H2,1H3,(H,12,13)
InChIKey
QQXBRVQJMKBAOZ-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C1=CC=C(CBr)C=C1)C
CAS DataBase Reference
111128-12-2(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-27-36/37/39-45-37/39
RIDADR 
UN 1759 8/PG 2
WGK Germany 
3
HazardClass 
8
PackingGroup 
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
530360
Product name
2-[4-(Bromomethyl)phenyl]propionic acid
Purity
96%
Packaging
25g
Price
$537
Updated
2023/06/20
TCI Chemical
Product number
B2101
Product name
2-[4-(Bromomethyl)phenyl]propionic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
B2101
Product name
2-[4-(Bromomethyl)phenyl]propionic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$207
Updated
2024/03/01
Alfa Aesar
Product number
H60763
Product name
2-[4-(Bromomethyl)phenyl]propionic acid, 96%
Packaging
5g
Price
$71.65
Updated
2024/03/01
Alfa Aesar
Product number
H60763
Product name
2-[4-(Bromomethyl)phenyl]propionic acid, 96%
Packaging
25g
Price
$288.65
Updated
2024/03/01
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2-(4-Bromomethyl)phenylpropionic acid Chemical Properties,Usage,Production

Chemical Properties

beige-cream crystalline powder

Uses

2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.

General Description

2-[4-(Bromomethyl)phenyl]propionic acid is a propionic acid derivative. Its enthalpy of vaporization at boiling point (421.15K) is 36.363kjoule/mol and density at 25°C is 1.4212g/ml.

Synthesis

The synthesis method comprises the following steps: dissolving sodium hydroxide in excessive methanol to react with p-chloro-tolualdehyde to obtain p-methoxy-tolualdehyde, andthen performing chloromethylation reaction on the p-methoxy tolualdehyde and concentrated hydrochloric acid in the existence of sulfuric acid to obtain p-chloromethyl benzyl ether; performing nucleophilic reaction on the p-chloromethyl benzyl ether and the sodium cyanide to obtain p-methoxy-methyl benzyl cyanide; reacting the p-methoxy-methyl benzyl cyanide with dimethyl carbonate under high pressure in the existence of a catalyst to obtain p-methoxy-methyl benzyl iso-propionitrile; and reacting the p-methoxy-methylbenzyl sodium isopropionate with excessive concentrate sulfuric acid to generate molten salt which is reacted with hydrobromic acid to obtain 2-(4-Bromomethyl)phenylpropionic acid.

2-(4-Bromomethyl)phenylpropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Bromomethyl)phenylpropionic acid Suppliers

Sinfachem Limited
Tel
025-84683399 13952017251
Fax
025-84683112
Email
sales@sinfachem.com
Country
China
ProdList
217
Advantage
56
Jinan Derifeng Environmental Protection Chemical Co., Ltd.
Tel
0531-83554928 13854196079
Fax
0531-83554928
Email
936804155@qq.com
Country
China
ProdList
11
Advantage
58
Suzhou Huaxin Pharmaceutical Technology Co., Ltd.
Tel
0512-67260010 13773004275
Email
vic.xu@hx-pharma.com
Country
China
ProdList
20
Advantage
58
Shangqiu Ladybug Network Technology Co., LTD
Tel
0370-2070160 17550096163
Fax
18736733639
Email
2986449836@qq.com
Country
China
ProdList
3028
Advantage
58
Suzhou Gopon Pharmaceutical Co., Ltd
Tel
13358059751
Email
gopon2012@gmail.com
Country
China
ProdList
297
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from 2-(4-Bromomethyl)phenylpropionic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-09-22
Hebei Weibang Biotechnology Co., Ltd
Product
2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Career Henan Chemica Co
Product
2-(4-Bromomethyl)phenylpropionic acid 11128-12-2
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29

111128-12-2, 2-(4-Bromomethyl)phenylpropionic acidRelated Search:


  • 4-(BROMOMETHYL)HYDRATROPIC ACID
  • 2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID
  • 2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID
  • 2-[(P-BROMOMETHYL)PHENYL]PROPIONIC ACID
  • BMPPA
  • 2-[4-(Bromomethyl)phenyl]propinic acid
  • Loxoprofen Intermediate
  • 2-(4-bromomethylphenyl)propionic acid (intermediate of loxoprofen)
  • 2-[4-(bromomethyl)phenyl]propanoic acid (intermediate of loxoprofen)
  • 2-(4-BROMOMETHYL)PHENYLPROPIONIC ACID 97%
  • 2-(4-Bromomethyl)phenylpropionic acid,97%
  • 2-[p-(Bromomethyl)phenyl]propanoic acid
  • 2-((4-Bromomethyl)phenyl)propanic acid
  • 2-(4-BroMoMethyl)phenylpropionic acid, 97% 5GR
  • 2-(4-BoroMoMethyl phenyl)propionic Acid
  • 2-[4-(Bromomethyl)phenyl]propionic acid, 4-(1-Carboxyethyl)benzyl bromide
  • 3-(2-(broMoMethyl)phenyl)propanoic acid
  • 2-[4-(Xiu Jiaji)phenyl]propionate
  • Loxoprofen Impurity 28
  • (2R)-2-[4-(bromomethyl)phenyl]propanoate
  • 2-[4-(Bromomethyl)phenyl]propionic Acid &gt
  • Benzeneacetic acid, 4-(bromomethyl)-α-methyl-
  • 2- ( 4-Bromomethyl )c phenylpropionic acid
  • p-Bromomethyl isocyanate
  • 2-(4-Bromomethyl)phenylpropionic acid Synonyms
  • Benzeneacetic acid, 4-(bromomethyl)-α-methyl-
  • Loxoprofen Sodium intermediate
  • Loxoprofen 16
  • 111128-12-2
  • 11128-12-2
  • C10H11BrO2
  • BrCH2C6H4CHCH3CO2H
  • C10H10BrO2
  • Building Blocks
  • C10
  • Carbonyl Compounds
  • Carboxylic Acids
  • Organic Building Blocks
  • Pharmaceutical intermediate
  • Organic acids
  • (intermediate of loxoprofen)
  • C10
  • Carbonyl Compounds
  • Carboxylic Acids
  • Aromatic Propionic Acids