2-(4-Bromomethyl)phenylpropionic acid

Product Name: 2-(4-Bromomethyl)phenylpropionic acid
CAS No.: 111128-12-2
Chemical Name: 2-(4-Bromomethyl)phenylpropionic acid
Synonyms: BMPPA;2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID;2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID;Loxoprofen 16;Loxoprofen sodium 16;Loxoprofen Impurity 28;Loxoprofen Intermediate;p-Bromomethyl isocyanate;Loxoprofen Sodium intermediate;4-(BROMOMETHYL)HYDRATROPIC ACID
CBNumber: CB3420139
Molecular Formula: C10H11BrO2
Formula Weight: 243.1
MOL File: 111128-12-2.mol

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2-(4-Bromomethyl)phenylpropionic acid Property

Melting point:: 126-130 °C(lit.)
Boiling point:: 148°C (rough estimate)
Density: 1.4557 (rough estimate)
refractive index: 1.5220 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 4.29±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C10H11BrO2/c1-7(10(12)13)9-4-2-8(6-11)3-5-9/h2-5,7H,6H2,1H3,(H,12,13)
InChIKey: QQXBRVQJMKBAOZ-UHFFFAOYSA-N
SMILES: C(O)(=O)C(C1=CC=C(CBr)C=C1)C
CAS DataBase Reference: 111128-12-2(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 26-27-36/37/39-45-37/39
RIDADR: UN 1759 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: Ⅱ
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 530360
Product name: 2-[4-(Bromomethyl)phenyl]propionic acid
Purity: 96%
Packaging: 25g
Price: $537
Updated: 2023/06/20

TCI Chemical

Product number: B2101
Product name: 2-[4-(Bromomethyl)phenyl]propionic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: B2101
Product name: 2-[4-(Bromomethyl)phenyl]propionic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $186
Updated: 2025/07/31

TRC

Product number: B415946
Product name: 2-[4-(Bromomethyl)phenyl]propionic acid
Packaging: 10g
Price: $65
Updated: 2021/12/16

TRC

Product number: B415946
Product name: 2-[4-(Bromomethyl)phenyl]propionic acid
Packaging: 100g
Price: $125
Updated: 2021/12/16

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2-(4-Bromomethyl)phenylpropionic acid Chemical Properties,Usage,Production

Chemical Properties

beige-cream crystalline powder

Uses

2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.

General Description

2-[4-(Bromomethyl)phenyl]propionic acid is a propionic acid derivative. Its enthalpy of vaporization at boiling point (421.15K) is 36.363kjoule/mol and density at 25°C is 1.4212g/ml.

Synthesis

The synthesis method comprises the following steps: dissolving sodium hydroxide in excessive methanol to react with p-chloro-tolualdehyde to obtain p-methoxy-tolualdehyde, andthen performing chloromethylation reaction on the p-methoxy tolualdehyde and concentrated hydrochloric acid in the existence of sulfuric acid to obtain p-chloromethyl benzyl ether; performing nucleophilic reaction on the p-chloromethyl benzyl ether and the sodium cyanide to obtain p-methoxy-methyl benzyl cyanide; reacting the p-methoxy-methyl benzyl cyanide with dimethyl carbonate under high pressure in the existence of a catalyst to obtain p-methoxy-methyl benzyl iso-propionitrile; and reacting the p-methoxy-methylbenzyl sodium isopropionate with excessive concentrate sulfuric acid to generate molten salt which is reacted with hydrobromic acid to obtain 2-(4-Bromomethyl)phenylpropionic acid.

References

[1] Patent: CN104744237, 2016, B. Location in patent: Paragraph 0027; 0042; 0048; 0049
[2] Patent: CN105753685, 2016, A. Location in patent: Paragraph 0104; 0105
[3] Patent: CN106866404, 2017, A. Location in patent: Paragraph 0013
[4] Patent: CN107573230, 2018, A. Location in patent: Paragraph 0024; 0025; 0026; 0027; 0028; 0029; 0030; 0031

2-(4-Bromomethyl)phenylpropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Bromomethyl)phenylpropionic acid Suppliers

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View Lastest Price from 2-(4-Bromomethyl)phenylpropionic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-09-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-02

111128-12-2, 2-(4-Bromomethyl)phenylpropionic acidRelated Search:

Ethyl 3-bromopropionate 3-Bromopropionic acid (S)-(+)-2-Phenylpropionic acid Chlorodimethylphenylsilane Pimecrolimus Entacapone Ciprofloxacin hydrochloride 2,2-Bis(hydroxymethyl)propionic acid 4-Bromomethylbenzoic acid Methyl bromide Loxoprofen 4-(BROMOMETHYL)PHENYLACETIC ACID 4-ISOPROPYL BENZYL BROMIDE 97 1-(bromomethyl)-4-ethylbenzene 2-[p-(1-Bromo-2-methylpropyl)phenyl]propionic Acid 2-(4-Bromomethyl)phenylpropionic acid p-Bromomethylphenylpropionic acid 2-(4-BROMOMETHYL-PHENYL)-2-METHYL-PROPIONIC ACID METHYL ESTER

4-(BROMOMETHYL)HYDRATROPIC ACID

2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID

2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID

2-[(P-BROMOMETHYL)PHENYL]PROPIONIC ACID

BMPPA

2-[4-(Bromomethyl)phenyl]propinic acid

Loxoprofen Intermediate

2-(4-bromomethylphenyl)propionic acid (intermediate of loxoprofen)

2-[4-(bromomethyl)phenyl]propanoic acid (intermediate of loxoprofen)

2-(4-BROMOMETHYL)PHENYLPROPIONIC ACID 97%

2-(4-Bromomethyl)phenylpropionic acid,97%

2-[p-(Bromomethyl)phenyl]propanoic acid

2-((4-Bromomethyl)phenyl)propanic acid

2-(4-BroMoMethyl)phenylpropionic acid, 97% 5GR

2-(4-BoroMoMethyl phenyl)propionic Acid

2-[4-(Bromomethyl)phenyl]propionic acid, 4-(1-Carboxyethyl)benzyl bromide

3-(2-(broMoMethyl)phenyl)propanoic acid

2-[4-(Xiu Jiaji)phenyl]propionate

Loxoprofen Impurity 28

(2R)-2-[4-(bromomethyl)phenyl]propanoate

2-[4-(Bromomethyl)phenyl]propionic Acid &gt

Benzeneacetic acid, 4-(bromomethyl)-α-methyl-

2- （ 4-Bromomethyl ）c phenylpropionic acid

p-Bromomethyl isocyanate

2-(4-Bromomethyl)phenylpropionic acid Synonyms

Loxoprofen Sodium intermediate

Loxoprofen 16

4-(Bromomethyl)-α-methylbenzeneaceticacid

Loxoprofen sodium 16

Bromomethyl)phenylpropionic acid

111128-12-2

11128-12-2

111125-12-2

C10H11BrO2

BrCH2C6H4CHCH3CO2H

C10H10BrO2

Building Blocks

C10

Carbonyl Compounds

Carboxylic Acids

Organic Building Blocks

Pharmaceutical intermediate

Organic acids

(intermediate of loxoprofen)

C10

Carbonyl Compounds

Carboxylic Acids

Aromatic Propionic Acids