2-(4-Bromomethyl)phenylpropionic acid
- Product Name
- 2-(4-Bromomethyl)phenylpropionic acid
- CAS No.
- 111128-12-2
- Chemical Name
- 2-(4-Bromomethyl)phenylpropionic acid
- Synonyms
- BMPPA;2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID;2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID;Loxoprofen 16;Loxoprofen Impurity 28;Loxoprofen Intermediate;p-Bromomethyl isocyanate;Loxoprofen Sodium intermediate;4-(BROMOMETHYL)HYDRATROPIC ACID;2-[4-(Xiu Jiaji)phenyl]propionate
- CBNumber
- CB3420139
- Molecular Formula
- C10H11BrO2
- Formula Weight
- 243.1
- MOL File
- 111128-12-2.mol
2-(4-Bromomethyl)phenylpropionic acid Property
- Melting point:
- 126-130 °C(lit.)
- Boiling point:
- 148°C (rough estimate)
- Density
- 1.4557 (rough estimate)
- refractive index
- 1.5220 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- powder to crystal
- pka
- 4.29±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C10H11BrO2/c1-7(10(12)13)9-4-2-8(6-11)3-5-9/h2-5,7H,6H2,1H3,(H,12,13)
- InChIKey
- QQXBRVQJMKBAOZ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C1=CC=C(CBr)C=C1)C
- CAS DataBase Reference
- 111128-12-2(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-27-36/37/39-45-37/39
- RIDADR
- UN 1759 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- Ⅱ
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 530360
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid
- Purity
- 96%
- Packaging
- 25g
- Price
- $537
- Updated
- 2023/06/20
- Product number
- B2101
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- B2101
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $207
- Updated
- 2024/03/01
- Product number
- H60763
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid, 96%
- Packaging
- 5g
- Price
- $71.65
- Updated
- 2024/03/01
- Product number
- H60763
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid, 96%
- Packaging
- 25g
- Price
- $288.65
- Updated
- 2024/03/01
2-(4-Bromomethyl)phenylpropionic acid Chemical Properties,Usage,Production
Chemical Properties
beige-cream crystalline powder
Uses
2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.
General Description
2-[4-(Bromomethyl)phenyl]propionic acid is a propionic acid derivative. Its enthalpy of vaporization at boiling point (421.15K) is 36.363kjoule/mol and density at 25°C is 1.4212g/ml.
Synthesis
The synthesis method comprises the following steps: dissolving sodium hydroxide in excessive methanol to react with p-chloro-tolualdehyde to obtain p-methoxy-tolualdehyde, andthen performing chloromethylation reaction on the p-methoxy tolualdehyde and concentrated hydrochloric acid in the existence of sulfuric acid to obtain p-chloromethyl benzyl ether; performing nucleophilic reaction on the p-chloromethyl benzyl ether and the sodium cyanide to obtain p-methoxy-methyl benzyl cyanide; reacting the p-methoxy-methyl benzyl cyanide with dimethyl carbonate under high pressure in the existence of a catalyst to obtain p-methoxy-methyl benzyl iso-propionitrile; and reacting the p-methoxy-methylbenzyl sodium isopropionate with excessive concentrate sulfuric acid to generate molten salt which is reacted with hydrobromic acid to obtain 2-(4-Bromomethyl)phenylpropionic acid.
2-(4-Bromomethyl)phenylpropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-Bromomethyl)phenylpropionic acid manufacturers
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-09-22
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 11128-12-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07