ChemicalBook > CAS DataBase List > 2-(4-Bromomethyl)phenylpropionic acid
2-(4-Bromomethyl)phenylpropionic acid
- Product Name
- 2-(4-Bromomethyl)phenylpropionic acid
- CAS No.
- 111128-12-2
- Chemical Name
- 2-(4-Bromomethyl)phenylpropionic acid
- Synonyms
- BMPPA;2-[4-(BROMOMETHYL)PHENYL]PROPIONIC ACID;2-[4-(BROMOMETHYL)PHENYL]PROPANOIC ACID;Loxoprofen 16;Loxoprofen Impurity 28;Loxoprofen Intermediate;p-Bromomethyl isocyanate;Loxoprofen Sodium intermediate;4-(BROMOMETHYL)HYDRATROPIC ACID;2-[4-(Xiu Jiaji)phenyl]propionate
- CBNumber
- CB3420139
- Molecular Formula
- C10H11BrO2
- Formula Weight
- 243.1
- MOL File
- 111128-12-2.mol
More
Less
2-(4-Bromomethyl)phenylpropionic acid Property
- Melting point:
- 126-130 °C(lit.)
- Boiling point:
- 148°C (rough estimate)
- Density
- 1.4557 (rough estimate)
- refractive index
- 1.5220 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- powder to crystal
- pka
- 4.29±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C10H11BrO2/c1-7(10(12)13)9-4-2-8(6-11)3-5-9/h2-5,7H,6H2,1H3,(H,12,13)
- InChIKey
- QQXBRVQJMKBAOZ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C1=CC=C(CBr)C=C1)C
- CAS DataBase Reference
- 111128-12-2(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-27-36/37/39-45-37/39
- RIDADR
- UN 1759 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- Ⅱ
- HS Code
- 29163990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 530360
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid
- Purity
- 96%
- Packaging
- 25g
- Price
- $537
- Updated
- 2023/06/20
TCI Chemical
- Product number
- B2101
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $68
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B2101
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $207
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H60763
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid, 96%
- Packaging
- 5g
- Price
- $71.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H60763
- Product name
- 2-[4-(Bromomethyl)phenyl]propionic acid, 96%
- Packaging
- 25g
- Price
- $288.65
- Updated
- 2024/03/01
More
Less
2-(4-Bromomethyl)phenylpropionic acid Chemical Properties,Usage,Production
Chemical Properties
beige-cream crystalline powder
Uses
2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.
General Description
2-[4-(Bromomethyl)phenyl]propionic acid is a propionic acid derivative. Its enthalpy of vaporization at boiling point (421.15K) is 36.363kjoule/mol and density at 25°C is 1.4212g/ml.
Synthesis
The synthesis method comprises the following steps: dissolving sodium hydroxide in excessive methanol to react with p-chloro-tolualdehyde to obtain p-methoxy-tolualdehyde, andthen performing chloromethylation reaction on the p-methoxy tolualdehyde and concentrated hydrochloric acid in the existence of sulfuric acid to obtain p-chloromethyl benzyl ether; performing nucleophilic reaction on the p-chloromethyl benzyl ether and the sodium cyanide to obtain p-methoxy-methyl benzyl cyanide; reacting the p-methoxy-methyl benzyl cyanide with dimethyl carbonate under high pressure in the existence of a catalyst to obtain p-methoxy-methyl benzyl iso-propionitrile; and reacting the p-methoxy-methylbenzyl sodium isopropionate with excessive concentrate sulfuric acid to generate molten salt which is reacted with hydrobromic acid to obtain 2-(4-Bromomethyl)phenylpropionic acid.
2-(4-Bromomethyl)phenylpropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-(4-Bromomethyl)phenylpropionic acid Suppliers
- Tel
- 025-84683399 13952017251
- Fax
- 025-84683112
- sales@sinfachem.com
- Country
- China
- ProdList
- 217
- Advantage
- 56
- Tel
- 0531-83554928 13854196079
- Fax
- 0531-83554928
- 936804155@qq.com
- Country
- China
- ProdList
- 11
- Advantage
- 58
- Tel
- 0512-67260010 13773004275
- vic.xu@hx-pharma.com
- Country
- China
- ProdList
- 20
- Advantage
- 58
- Tel
- 0370-2070160 17550096163
- Fax
- 18736733639
- 2986449836@qq.com
- Country
- China
- ProdList
- 3028
- Advantage
- 58
- Tel
- 13358059751
- gopon2012@gmail.com
- Country
- China
- ProdList
- 297
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- 82899734
- Fax
- +86-519-82899734
- Country
- China
- ProdList
- 51
- Advantage
- 64
- Tel
- 021-021-57872719 13761402923
- Fax
- 02157872719
- 245662540@qq.com
- Country
- China
- ProdList
- 309
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19172
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8838
- Advantage
- 52
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 021-53292253
- Fax
- 021-53292253
- biz@synches.com
- Country
- China
- ProdList
- 199
- Advantage
- 64
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3203
- Advantage
- 55
- Tel
- 021-33690831-8001 13552411790
- Fax
- 021-33690831
- postmaster@tyjchem.cn
- Country
- China
- ProdList
- 1541
- Advantage
- 55
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2871
- Advantage
- 58
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19915
- Advantage
- 55
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9347
- Advantage
- 55
- Tel
- 021-34666753 13311639313
- Fax
- +86-21-34979012
- info@shyrchem.com
- Country
- China
- ProdList
- 571
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 86-21-50102722
- Fax
- 86-21-50102722
- Country
- China
- ProdList
- 26
- Advantage
- 55
- Tel
- 021-60451683 15021268886
- Fax
- +86-21-60451682
- sales@arborchemical.com
- Country
- China
- ProdList
- 855
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 15902102743
- Fax
- 0731-57805668
- shelley@furuipharma.com
- Country
- China
- ProdList
- 452
- Advantage
- 55
- Tel
- 0532-87118899
- Fax
- 0532-84117788
- sales@kingwaypharm.com
- Country
- China
- ProdList
- 119
- Advantage
- 56
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9978
- Advantage
- 55
- Tel
- 18136598690 18136597130
- Fax
- 86-0519-89617886
- Country
- China
- ProdList
- 235
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- +86 574 8729 6330
- Fax
- +86 574 8729 7461
- info@chemik.com
- Country
- China
- ProdList
- 3616
- Advantage
- 61
- Tel
- 0371-13526885213 15637198702
- Fax
- 0371-63709726
- xpkchem@163.com
- Country
- China
- ProdList
- 3991
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9346
- Advantage
- 58
More
Less
View Lastest Price from 2-(4-Bromomethyl)phenylpropionic acid manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-09-22
Hebei Weibang Biotechnology Co., Ltd
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 111128-12-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-19
Career Henan Chemica Co
- Product
- 2-(4-Bromomethyl)phenylpropionic acid 11128-12-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29
111128-12-2, 2-(4-Bromomethyl)phenylpropionic acidRelated Search:
Ethyl 3-bromopropionate
3-Bromopropionic acid
(S)-(+)-2-Phenylpropionic acid
Chlorodimethylphenylsilane
Pimecrolimus
Entacapone
Ciprofloxacin hydrochloride
2,2-Bis(hydroxymethyl)propionic acid
4-Bromomethylbenzoic acid
Methyl bromide
Loxoprofen
4-(BROMOMETHYL)PHENYLACETIC ACID
4-ISOPROPYL BENZYL BROMIDE 97
1-(bromomethyl)-4-ethylbenzene
2-[p-(1-Bromo-2-methylpropyl)phenyl]propionic Acid
2-(4-Bromomethyl)phenylpropionic acid
p-Bromomethylphenylpropionic acid
2-(4-BROMOMETHYL-PHENYL)-2-METHYL-PROPIONIC ACID METHYL ESTER