2-(Dimethylaminomethyl)-3-hydroxypyridine

Product Name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
CAS No.: 2168-13-0
Chemical Name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
Synonyms: 2(-DIMETHYLAMINOMETHYL)-3-PYRIDOL;2-DIMETHYLAMINOMETHYL-3-PYRIDINOL;2-(Dimethylaminomethyl)pyridine-3-ol;2-[(dimethylamino)methyl]pyridin-3-ol;3-Pyridinol, 2-[(dimethylamino)methyl]-;2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE;3-Hydroxy-2-(dimethylaminomethyl)-pyridine;2-(Dimethylaminomethyl)-3-hydroxypyridine,97%;2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE 97%;2-Dimethylaminomethyl-3-hydroxypyridine 97% min
CBNumber: CB1360789
Molecular Formula: C8H12N2O
Formula Weight: 152.19
MOL File: 2168-13-0.mol

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2-(Dimethylaminomethyl)-3-hydroxypyridine Property

Melting point:: 56-59 °C(lit.)
Boiling point:: 98 °C4 mm Hg(lit.)
Density: 1.0996 (rough estimate)
refractive index: 1.4940 (estimate)
storage temp.: Storage temp. 2-8°C
pka: 8.79±0.10(Predicted)
form: solid
Appearance: Off-white to light yellow Solid
CAS DataBase Reference: 2168-13-0
NIST Chemistry Reference: 2-(Dimethylaminomethyl)-3-hydroxypyridine(2168-13-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D492850
Product name: 2-((Dimethylamino)methyl)pyridin-3-ol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: D492850
Product name: 2-((Dimethylamino)methyl)pyridin-3-ol
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD54868
Product name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
Packaging: 2g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR933407
Product name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
Purity: 95%
Packaging: 25g
Price: $300
Updated: 2021/12/16

Apolloscientific

Product number: OR933407
Product name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
Purity: 95%
Packaging: 5g
Price: $100
Updated: 2021/12/16

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2-(Dimethylaminomethyl)-3-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

white to beige crystalline powder

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2969, 1949 DOI: 10.1021/ja01177a007

Synthesis

109-00-2

50-00-0

124-40-3

2168-13-0

To a solution of 3-hydroxypyridine (200 g, 2.10 mol) in water (500 mL) was sequentially added 50% aqueous dimethylamine (228 g) and 36% aqueous formaldehyde (210 g), and the reaction mixture was stirred at room temperature, then heated up to 50 °C and kept for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the precipitated crystals were collected by filtration to afford the target product 2-(dimethylaminomethyl)-3-hydroxypyridine (207 g, 65% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.38 (6H, s), 3.86 (2H, s), 7.01-7.18 (2H, m), 8.00 (1H, t, J = 3.2 Hz), and a hidden proton signal.

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 16, p. 7034 - 7042
[2] Patent: EP2100895, 2009, A1. Location in patent: Page/Page column 74-75
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2968,2971

2-(Dimethylaminomethyl)-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Dimethylaminomethyl)-3-hydroxypyridine Suppliers

Belgium 1 China 45 France 2 Germany 4 India 1 Russia 1 Slovakia 1 Switzerland 1 United Kingdom 4 United States 16 Global 76

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Sigma-Aldrich

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View Lastest Price from 2-(Dimethylaminomethyl)-3-hydroxypyridine manufacturers

Dideu Industries Group Limited

Product: 2-(Dimethylaminomethyl)-3-hydroxypyridine 2168-13-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

2168-13-0, 2-(Dimethylaminomethyl)-3-hydroxypyridineRelated Search:

3-Hydroxypyridine Dimethyl sulfoxide N,N-Dimethylformamide 2-Chloro-3-hydroxypyridine Poly(dimethylsiloxane) 2,6-Lutidine 2-(1-Piperidinylmethyl)-3-pyridinol 2-(Dimethylaminomethyl)-3-hydroxypyridine 3-[(4,6-DIMETHYLPYRIMIDIN-2-YL)OXY]-N-METHYL-N-PHENYL-2-PYRIDINEMETHANAMINE 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-N-(4-METHOXYPHENYL)-N-METHYL-2-PYRIDINEMETHANAMINE (2S,4R)-1-[[3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PYRIDIN-2-YL]CARBONYL]-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID, ETHYL ESTER 1-BENZYL-5-OXO-3-PYRROLIDINECARBOXYLIC ACID 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-N-METHYL-N-PHENYL-2-PYRIDINEMETHANAMINE (4S)-3-[[3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PYRIDIN-2-YL]CARBONYL]THIAZOLIDINE-4-CARBOXYLIC ACID, METHYL ESTER 2-((Isopentylmethylamino)methyl)-3-pyridinol dimethylcarbamate oxalate 3-Pyridinol, 2-(1-piperidinylmethyl)-, dimethylcarbamate, oxalate aminostigmine 1-(3,4-DIMETHOXY-PYRIDIN-2-YLMETHYL)-PIPERAZINE

2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE

2-DIMETHYLAMINOMETHYL-3-PYRIDINOL

2(-DIMETHYLAMINOMETHYL)-3-PYRIDOL

3-Pyridinol, 2-[(dimethylamino)methyl]-

2-[(dimethylamino)methyl]pyridin-3-ol

3-Hydroxy-2-(dimethylaminomethyl)-pyridine

2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE 97%

2-(Dimethylaminomethyl)pyridine-3-ol

2-(Dimethylaminomethyl)-3-hydroxypyridine,97%

2-Dimethylaminomethyl-3-hydroxypyridine 97% min

2-(Dimethylaminomethyl)-3-hydroxypyridine≥ 95% (HPLC)

2-(Dimethylaminomethyl)-3-hydroxypyridine ISO 9001：2015 REACH

2168-13-0

Building Blocks

C7 and C8

Heterocyclic Building Blocks

Pyridines