N-Trityl-L-serine methyl ester
- Product Name
- N-Trityl-L-serine methyl ester
- CAS No.
- 4465-44-5
- Chemical Name
- N-Trityl-L-serine methyl ester
- Synonyms
- Trt-Ser-OMe;(S)-methyl 3-hydroxy-2-(tritylamino)propanoate;Methyl trityl-L-serinate;methyl (2S)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate;Trt-L-Ser-Ome;Trt-L-Ser-Ome-OH;(diphenylMethyl)benzene;(4S)-4-aMinooxolan-3-one;Methyl N-trityl-L-serinate;N-TRITYL-L-SERINE METHYL ESTER
- CBNumber
- CB1369166
- Molecular Formula
- C23H23NO3
- Formula Weight
- 361.43
- MOL File
- 4465-44-5.mol
N-Trityl-L-serine methyl ester Property
- Melting point:
- 148-150 °C (lit.)
- Boiling point:
- 538.2±50.0 °C(Predicted)
- alpha
- 31 º (c=1 in methanol)
- Density
- 1.169±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 14.01±0.10(Predicted)
- color
- White to Light yellow
- optical activity
- [α]20/D +31°, c = 1 in methanol
- InChI
- InChI=1S/C23H23NO3/c1-27-22(26)21(17-25)24-23(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24-25H,17H2,1H3/t21-/m0/s1
- InChIKey
- LXAWQKKSNNYYEK-NRFANRHFSA-N
- SMILES
- C(OC)(=O)[C@H](CO)NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 411345
- Product name
- N-Trityl-L-serine methyl ester
- Purity
- 99%
- Packaging
- 25g
- Price
- $426
- Updated
- 2025/07/31
- Product number
- T2870
- Product name
- N-(Triphenylmethyl)-L-serine Methyl Ester
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- T2870
- Product name
- N-(Triphenylmethyl)-L-serine Methyl Ester
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $232
- Updated
- 2025/07/31
- Product number
- T888923
- Product name
- N-Trityl-L-serine methyl ester
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- T888923
- Product name
- N-Trityl-L-serine methyl ester
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
N-Trityl-L-serine methyl ester Chemical Properties,Usage,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
5680-80-8
76-83-5
13515-76-9
A solution of dichloromethane (CH2Cl2, 40 mL) with triethylamine (Et3N, 13.4 mL, 96.78 mmol) was slowly added dropwise to a dichloromethane (CH2Cl2, 129 mL) containing L-serine methyl ester hydrochloride (5.0 g, 32.26 mmol) and triphenylmethane chloride (Ph3CCl, 13.5 g, 48.39 mmol) solution and the reaction was carried out at 0 °C under the protection of nitrogen (N2). Subsequently, the reaction system was gradually warmed up to room temperature with continuous stirring overnight. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and the aqueous phase was extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford N-trityl-L-serine methyl ester as a colorless solid (11.41 g, 98% yield).
References
[1] Acta Chemica Scandinavica, 1994, vol. 48, # 6, p. 511 - 516
[2] Patent: WO2007/68474, 2007, A1. Location in patent: Page/Page column 51; 52
[3] Patent: WO2016/8946, 2016, A1. Location in patent: Page/Page column 101
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 40, p. 12245 - 12249
[5] Angew. Chem., 2017, vol. 129, p. 12413 - 12417,5
N-Trityl-L-serine methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Trityl-L-serine methyl ester manufacturers
- Product
- Trt-L-Ser-Ome 4465-44-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-02
- Product
- N-Trityl-L-serine methyl ester 4465-44-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-16