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L-Histidine hydrochloride monohydrate

Product Name
L-Histidine hydrochloride monohydrate
CAS No.
5934-29-2
Chemical Name
L-Histidine hydrochloride monohydrate
Synonyms
15N3, 98%);L-HIS HCL H2O;L-His.H2o.HCl;Histidine (H);HISTIDINE HCL;H-His-OH¤HCl¤H;L-HISTIDINEHCL;H-HIS-OH HCL H2O;L-His-OH·HCl·H2O;HISTIDINE HCL H2O
CBNumber
CB1369616
Molecular Formula
C6H12ClN3O3
Formula Weight
209.63
MOL File
5934-29-2.mol
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L-Histidine hydrochloride monohydrate Property

Melting point:
254 °C (dec.)(lit.)
alpha 
9.9 º (c=11, 6 N HCl)
Density 
1.49 g/cm3
vapor pressure 
<1 hPa (20 °C)
storage temp. 
Store below +30°C.
solubility 
H2O: 100 mg/mL
form 
Solid
color 
White
Odor
odorless
PH
3.5-4.5 (100g/l, H2O, 20℃)
PH Range
3 - 4 at 105 g/l at 25 °C
optical activity
[α]20/D +9.5±0.5°, c = 5% in 5 M HCl
Water Solubility 
169.9 g/L (20 ºC)
Merck 
14,4720
BRN 
4168261
InChIKey
CMXXUDSWGMGYLZ-XRIGFGBMSA-N
LogP
-3.32 at 25℃
CAS DataBase Reference
5934-29-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36/37-26
WGK Germany 
3
RTECS 
MS3119000
F 
10
TSCA 
Yes
HS Code 
29332990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5659
Product name
L-Histidine monohydrochloride monohydrate
Purity
from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%
Packaging
25G
Price
$52.3
Updated
2024/03/01
Sigma-Aldrich
Product number
H5659
Product name
L-Histidine monohydrochloride monohydrate
Purity
from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%
Packaging
100G
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
H5659
Product name
L-Histidine monohydrochloride monohydrate
Purity
from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%
Packaging
1KG
Price
$819
Updated
2024/03/01
Sigma-Aldrich
Product number
8.16005
Product name
(S)-(+)-Histidine hydrochloride monohydrate
Purity
for synthesis
Packaging
25g
Price
$38.1
Updated
2024/03/01
Sigma-Aldrich
Product number
53370
Product name
L-Histidine monohydrochloride monohydrate
Purity
≥99.0% (AT)
Packaging
25g
Price
$32.2
Updated
2024/03/01
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L-Histidine hydrochloride monohydrate Chemical Properties,Usage,Production

Chemical Properties

white crystals or cryst. or granular powder

Uses

L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.

Uses

L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

Uses

L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method.

General Description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Purification Methods

Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.]

L-Histidine hydrochloride monohydrate Preparation Products And Raw materials

Raw materials

HEMOGLOBIN Soy bean Isoflavone Isoflavone 10-40% L-Lysine Hydrolyzate Ion exchange resin column

Preparation Products

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L-Histidine hydrochloride monohydrate Suppliers

Belgium 3 Canada 2 China 310 Europe 3 France 3 Germany 16 India 35 Japan 12 Poland 1 Russia 1 Singapore 1 Switzerland 5 United Kingdom 16 United States 65 USA 1 Global 474
Nantong puyue biomedical Co., Ltd
Tel
051389158300 18014392889
Fax
0513-89158198
Email
sales8@puyerbiopharma.com
Country
China
ProdList
4316
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
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66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
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66
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View Lastest Price from L-Histidine hydrochloride monohydrate manufacturers

airuikechemical co., ltd.
Product
l-histidine hydrochloride monohydrate 5934-29-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Histidine hydrochloride monohydrate 5934-29-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
5000kg/month
Release date
2021-08-16
Hebei Yibangte Import and Export Co. , Ltd.
Product
L-Histidine hydrochloride monohydrate 5934-29-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
500000kg
Release date
2023-08-01

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