1-Acetyl-2-imidazolidinone

Uses

Product Name: 1-Acetyl-2-imidazolidinone
CAS No.: 5391-39-9
Chemical Name: 1-Acetyl-2-imidazolidinone
Synonyms: RARECHEM AQ NN 0041;ACETYL IMIDAZO-2-ONE;Clonidine Impurity A;Acetyl Ethylene Urea;Clonidine EP Impurity A;N-Acetylimidazolidinone;Clonidine IMpurity-A(BP);1-Acetyl-2-Imidazolidone;1-acetyl-2-imidazolidine;1-ACETYL-2-IMIDAZOLIDINONE
CBNumber: CB1370702
Molecular Formula: C5H8N2O2
Formula Weight: 128.13
MOL File: 5391-39-9.mol

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1-Acetyl-2-imidazolidinone Property

Melting point:: 173-175°C
Density: 1.237
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly, Heated)
form: Solid
pka: 12.11±0.20(Predicted)
color: White to Off-White
InChI: InChI=1S/C5H8N2O2/c1-4(8)7-3-2-6-5(7)9/h2-3H2,1H3,(H,6,9)
InChIKey: JJWACYUTERPMBM-UHFFFAOYSA-N
SMILES: C1(=O)N(C(C)=O)CCN1
CAS DataBase Reference: 5391-39-9(CAS DataBase Reference)

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Safety

HS Code: 2933.29.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R593206
Product name: 1-ACETYL-2-IMIDAZOLIDINONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: R593206
Product name: 1-ACETYL-2-IMIDAZOLIDINONE
Purity: AldrichCPR
Packaging: 50MG
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: A1945
Product name: 1-Acetyl-2-imidazolidinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: A1945
Product name: 1-Acetyl-2-imidazolidinone
Purity: >98.0%(GC)
Packaging: 25g
Price: $203
Updated: 2025/07/31

TRC

Product number: A167955
Product name: 1-Acetyl-2-imidazolidinone
Packaging: 25g
Price: $305
Updated: 2021/12/16

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1-Acetyl-2-imidazolidinone Chemical Properties,Usage,Production

Uses

1-Acetyl-2-imidazolidinone (Clonidine EP Impurity A) is a synthetic reagent used in the preparation of triple [14C]-labelled moxonidine which is an antihypertensive compound.

Uses

1-Acetyl-2-imidazolidinone (Clonidine EP Impurity A) is a synthetic reagent used in the preparation of triple [14C]-labelled moxonidine which is an antihypertensive compound.

Synthesis

120-93-4

108-24-7

5391-39-9

General procedure for the synthesis of 1-acetyl-2-imidazolidinone from 2-imidazolidinone and acetic anhydride: 5.18 g (60.2 mmol) of 2-imidazolidinone and 50 mL of acetic anhydride were added to a 100 mL round-bottom flask. The mixture was placed in an oil bath and the reaction was stirred at 150 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered to collect the precipitated solid. The solid was washed with a small amount of cold ethanol to give a final 4.94 g (yield: 64.1%) of colorless solid 1-acetyl-2-imidazolidinone.

References

[1] Chemistry - A European Journal, 2002, vol. 8, # 11, p. 2464 - 2475
[2] Patent: JP2016/145198, 2016, A. Location in patent: Paragraph 0087-0089
[3] Arkivoc, 2014, vol. 2014, # 2, p. 44 - 56
[4] Journal of the American Chemical Society, 1958, vol. 80, p. 6409,6412

1-Acetyl-2-imidazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Acetyl-2-imidazolidinone Suppliers

Americas 1 Belgium 1 Canada 4 China 273 Czech Republic 1 Europe 4 Germany 7 India 25 Japan 3 South Korea 1 United Kingdom 10 United States 34 Global 364

Vyzkumny Ustav Organickych Syntez A.S. (VUOS)

Tel: --
Fax: --
Email: vi@vuos.com
Country: Czech Republic
ProdList: 64
Advantage: 58

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View Lastest Price from 1-Acetyl-2-imidazolidinone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Acetyl-2-imidazolidinone 5391-39-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Acetyl-2-imidazolidinone 5391-39-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1-Acetylimidazolidin-2-one 5391-39-9
Price: US $75.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-28

5391-39-9, 1-Acetyl-2-imidazolidinone Related Search:

Imidazolidine Acetylacetone Imidazolidinyl urea Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetyl chloride Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 1,3-Dimethyl-2-imidazolidinone 2-Imidazolidone N-Carbethoxy-4-piperidone N-(tert-Butoxycarbonyl)-4-piperidone N-ACETYL-(2S)-BORNANE 10,2-SULTAM 1-Acetyl-5-broMo-6-chloro-1H-indol-3-yl acetate 6-CHLOROINDOXYL-1,3-DIACETATE AC-GLU-OME N-ACETYL-4-S-CYSTEAMINYLPHENOL 1-ACETYL-5-BROMO-7-NITROINDOLINE 1-acetyl-3-bromopiperidin-4-one hydrobromide

1-ethanoylimidazolidin-2-one

N-acetyl-2-iMidazolidazolidinone

Clonidine IMpurity-A(BP)

Clonidine Impurity A

2-Imidazolidinone,1-acetyl-

n-acetyl-2-imidazolidinone

RARECHEM AQ NN 0041

ACETYL IMIDAZO-2-ONE

1-ACETYL-IMIDAZOLIDIN-2-ONE

1-ACETYL-1,3,4,5-TETRAHYDROIMIDAZOLE-2-ONE

1-ACETYL-2-IMIDAZOLIDINONE

1-Acetyl-2-Imidazolidone

1-acetylimidazolidine-2-thione

Acetyl Ethylene Urea

1-acetyl-2-imidazolidine

1-acetyl-2-imidazol-1-iumone

Clonidine Impurity 1（Clonidine EP Impurity A)

Clonidine EP Impurity A

1-Acetyl-2-imidazolidinone &gt

N-Acetylimidazolidinone

Clonidine Hydrochloride EP Impurity A

Clonidine EP Impurity A 1-Acetylimidazolidin-2-one

Clonidine Hydrochloride Impurity A

5391-39-9

5391-53-9

C5H8N2O2

Imidazol&Benzimidazole

(intermediate of moxonidine hcl)