2-FLUORO-3-PYRIDINEMETHANAMINE

2-FLUORO-3-PYRIDINEMETHANAMINE Property

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

2-FLUORO-3-PYRIDINEMETHANAMINE Chemical Properties,Usage,Production

Application

2-Fluoro-3-pyridinemethylmethylamine is an amine organic compound that can be used as a pharmaceutical synthesis intermediate.

Synthesis

General procedure for the synthesis of 2-fluoro-3-pyridinylmethylamine from 2-fluoro-3-cyanopyridine: first, C-(2-fluoro-pyridin-3-yl)-methylamine hydrochloride was prepared. Concentrated hydrochloric acid (0.46 mL) was slowly added to a suspension of methanol (10 mL) containing 2-fluoro-3-cyanopyridine (0.34 g, 2.8 mmol) and 5% Pd/C (0.5 g) at room temperature. Subsequently, the reaction suspension was stirred continuously for 6 hours under a hydrogen atmosphere at 1 atmosphere. Upon completion of the reaction, the reaction mixture was filtered and the filtrate concentrated. Ether was added to the concentrated residue and HCl gas was passed through the suspension bulge. The resulting precipitate was filtered and dried to give the target product 2-fluoro-3-pyridylmethylmethylamine (0.37 g, 82% yield). Substance spectral analysis (ES) of the product showed a m/z of 127.1 ([M + H]+). The NMR hydrogen spectrum (400 MHz, DMSO-d6) data were as follows: δ 8.65 (broad single peak, 3H), 8.24 (multiple peaks, 1H), 8.16 (multiple peaks, 1H), 7.41 (multiple peaks, 1H), 4.06 (multiple peaks, 2H).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 59