Description Source Background
ChemicalBook > CAS DataBase List > HUMAN FGF-4

HUMAN FGF-4

Description Source Background
Product Name
HUMAN FGF-4
Chemical Name
HUMAN FGF-4
Synonyms
FGF-4;K-FGF;HST-1;hFGF-4;HBGF-4;HUMAN FGF-4;FGF-4, HUMAN;RECOMBINANT HUMAN FGF-4;transforming protein KS3;FIBROBLAST GROWTH FACTOR-4
CBNumber
CB1372993
Formula Weight
0
MOL File
Mol file
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HUMAN FGF-4 Property

storage temp. 
−20°C
form 
lyophilized powder
biological source
human
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F8424
Product name
Fibroblast Growth Factor-4 human
Purity
FGF-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Packaging
25μG
Price
$380
Updated
2025/07/31
Sigma-Aldrich
Product number
F8424
Product name
Fibroblast Growth Factor-4 human
Purity
FGF-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Packaging
100μG
Price
$1150
Updated
2025/07/31
Usbiological
Product number
025073
Product name
Fibroblast Growth Factor 4
Packaging
96Tests
Price
$851
Updated
2021/12/16
Usbiological
Product number
025072
Product name
Fibroblast Growth Factor 4
Packaging
96Tests
Price
$907
Updated
2021/12/16
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HUMAN FGF-4 Chemical Properties,Usage,Production

Uses

Fibroblast Growth Factor-4 human has been used:

  • To maintain trophectoderm stem cells.
  • In neurogenic differentiation.
  • In hepatocyte differentiation.

General Description

Fibroblast Growth Factor-4 (FGF4) is a 19 kDa protein, belonging to the FGF family of proteins. Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface. There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34 kDa and they possess a conserved sequence of 120 amino acids. The FGF4 gene is mapped to human chromosome 11q13.3.

Biochem/physiol Actions

Fibroblast growth factor-4 (FGF-4) is identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development. FGF-4 participates in cell differentiation and cell migration.

Description

FGF4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 182 amino acids and having a molecular mass of 19.8kDa.

The FGF4 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

HUMAN FGF-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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HUMAN FGF-4 Suppliers

Sigma-Aldrich
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HUMAN FGF-4Related Search:


  • RECOMBINANT HUMAN FGF-4
  • FIBROBLAST GROWTH FACTOR-4, HUMAN
  • FGF-4, HUMAN
  • FGF-4
  • FIBROBLAST GROWTH FACTOR-4
  • FIBROBLAST GROWTH FACTOR-4 HUMAN, RECOMBINANT
  • HUMAN FGF-4
  • HUMAN FIBROBLAST GROWTH FACTOR 4
  • hFGF-4
  • K-FGF
  • Heparin-binding growth factor 4
  • K-fibroblast growth factor
  • HBGF-4
  • HST-1
  • transforming protein KS3
  • Human