DFMO
- Product Name
- DFMO
- CAS No.
- 66640-93-5
- Chemical Name
- DFMO
- Synonyms
- DFMO;L-DFMO;L-RMI71782;EFLORNITINE;L-Eflornithine;H-DL-(F2ME)ORN-OH;DIFLUOROMETHYLORNITHINE;L-α-difluoromethylornithine;L Eflornithine,LEflornithine;H-ALPHA-DIFLUORO-ME-DL-ORN-OH
- CBNumber
- CB1373228
- Molecular Formula
- C6H12F2N2O2
- Formula Weight
- 182.17
- MOL File
- 66640-93-5.mol
DFMO Property
- Boiling point:
- 347.0±42.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 1.22±0.44(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MT-50140
- Product name
- Difluoromethylornithine
- Purity
- 98%
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
DFMO Chemical Properties,Usage,Production
Uses
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
target
KD: 1.3±0.3 μM (Ornithine decarboxylase, ODC)
References
[1] Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375(Pt 2):465-70. DOI:10.1042/BJ20030382
[2] Jansson-Lfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. DOI:10.1128/AAC.04101-14
DFMO Preparation Products And Raw materials
Raw materials
Preparation Products
DFMO Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32467
- Advantage
- 58
- Tel
- 13876246362
- Fax
- QQ : 422165847
- 18259433389@163.com
- Country
- China
- ProdList
- 500
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24960
- Advantage
- 58
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19957
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39040
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58