ChemicalBook > CAS DataBase List > DFMO
DFMO
- Product Name
- DFMO
- CAS No.
- 66640-93-5
- Chemical Name
- DFMO
- Synonyms
- DFMO;L-DFMO;L-RMI71782;EFLORNITINE;L-Eflornithine;H-DL-(F2ME)ORN-OH;DIFLUOROMETHYLORNITHINE;L-α-difluoromethylornithine;L-α-difluoromethylornithine;L Eflornithine,LEflornithine
- CBNumber
- CB1373228
- Molecular Formula
- C6H12F2N2O2
- Formula Weight
- 182.17
- MOL File
- 66640-93-5.mol
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DFMO Property
- Boiling point:
- 347.0±42.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 1.22±0.44(Predicted)
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N-Bromosuccinimide Price
AHH
- Product number
- MT-50140
- Product name
- Difluoromethylornithine
- Purity
- 98%
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
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DFMO Chemical Properties,Usage,Production
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
target
KD: 1.3±0.3 μM (Ornithine decarboxylase, ODC)
DFMO Preparation Products And Raw materials
Raw materials
Preparation Products
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DFMO Suppliers
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