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ChemicalBook > CAS DataBase List > 1-(3-BROMOPHENYL)PYRROLIDINE

1-(3-BROMOPHENYL)PYRROLIDINE

Application
Product Name
1-(3-BROMOPHENYL)PYRROLIDINE
CAS No.
219928-13-9
Chemical Name
1-(3-BROMOPHENYL)PYRROLIDINE
Synonyms
N-(3-BROMOPHENYL)PYRROLIDINE;1-(3-BROMOPHENYL)PYRROLIDINE;1-(3-Bromophenyl)pyrrolidine97%;Pyrrolidine, 1-(3-broMophenyl)-;1-(3-Bromophenyl)pyrrolidine 97%
CBNumber
CB1384763
Molecular Formula
C10H12BrN
Formula Weight
226.11
MOL File
219928-13-9.mol
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1-(3-BROMOPHENYL)PYRROLIDINE Property

Boiling point:
76/0.1mm
Density 
1.411±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.51±0.40(Predicted)
Appearance
Off-white to brown Solid
CAS DataBase Reference
219928-13-9
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Safety

Hazard Note 
Harmful
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B678323
Product name
1-(3-Bromophenyl)pyrrolidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR9182
Product name
1-(3-Bromophenyl)pyrrolidine
Purity
97%
Packaging
250mg
Price
$29
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-P7
Product name
1-(3-Bromophenyl)pyrrolidine
Purity
97%
Packaging
250mg
Price
$32
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153571
Product name
1-(3-Bromophenyl)pyrrolidine
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153571
Product name
1-(3-Bromophenyl)pyrrolidine
Packaging
1g
Price
$112.5
Updated
2021/12/16
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1-(3-BROMOPHENYL)PYRROLIDINE Chemical Properties,Usage,Production

Application

1-(3-bromophenyl)pyrrole is a heterocyclic organic compound that can be used to prepare lithium 3-(pyrrolidin-1-yl)benzenesulfinate.

Synthesis

123-75-1

108-36-1

219928-13-9

1. To a 500 mL three-necked round-bottomed flask was added a toluene solution (300 mL) of 1,3-dibromobenzene (20 g, 84.78 mmol, 1.00 eq.) under nitrogen protection. 2. To the reaction system was added pyrrolidine (6.03 g, 84.80 mmol, 1.00 eq.), Pd(OAc)2 (190 mg, 0.85 mmol, 0.01 eq.), BINAP (760 mg, 2.53 mmol, 0.03 eq.) and Cs2CO3 (69.1 g, 211.96 mmol, 2.50 equivalent). 3. The reaction mixture was stirred in an oil bath at 120 °C overnight and the progress of the reaction was monitored by TLC (Expander: EtOAc/PE = 1:5). 4. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure by rotary evaporator. 5. The residue was purified by column chromatography (eluent: PE) to afford 8.51 g (45% yield) of 1-(3-bromophenyl)pyrrolidine as a pale yellow liquid. 6. The product was analyzed by LC-MS. 6. The product was characterized by LC-MS: [M+H]+ m/z calculated value C10H13BrN 226, measured value 226.

References

[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6427 - 6434
[2] Tetrahedron, 2008, vol. 64, # 13, p. 2938 - 2950
[3] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0165
[4] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 44
[5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 66

1-(3-BROMOPHENYL)PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-BROMOPHENYL)PYRROLIDINE Suppliers

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219928-13-9, 1-(3-BROMOPHENYL)PYRROLIDINERelated Search:

1-(3-BROMOPHENYL)PYRROLIDINE 2-(2-Bromophenyl)pyrrolidine (R)-2-(2-BROMOPHENYL)PYRROLIDINE (S)-2-(2-BROMOPHENYL)PYRROLIDINE (S)-2-(4-BROMOPHENYL)PYRROLIDINE (3S,4R)-4-(2-BROMOPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID (R)-2-(4-BROMOPHENYL)PYRROLIDINE N-(4-BROMOPHENYL)PYRROLIDINE,1-(4-BROMOPHENYL)PYRROLIDINE (3S,4R)-4-(4-BROMOPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID (R)-2-(3-BROMOPHENYL)PYRROLIDINE (3S,4R)-4-(3-BROMOPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID BOC-(+/-)-TRANS-4-(3-BROMOPHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID 1-(3-bromophenyl)pyrrolidin-2-one N-(5-Bromo-2-nitrophenyl)-L-proline 1-(3-BROMOPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID N-(3-BROMOPHENYL)SUCCINIMIDE (+/-)-TRANS-4-(3-BROMOPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 3-(2-BROMOPHENYL)PYRROLIDINE

  • Pyrrolidine, 1-(3-broMophenyl)-
  • 1-(3-Bromophenyl)pyrrolidine 97%
  • 1-(3-BROMOPHENYL)PYRROLIDINE
  • N-(3-BROMOPHENYL)PYRROLIDINE
  • 1-(3-Bromophenyl)pyrrolidine97%
  • 219928-13-9
  • C10H12BrN
  • Amines
  • blocks
  • Bromides