7,12-DIMETHYLBENZ[A]ANTHRACENE
- Product Name
- 7,12-DIMETHYLBENZ[A]ANTHRACENE
- CAS No.
- 57-97-6
- Chemical Name
- 7,12-DIMETHYLBENZ[A]ANTHRACENE
- Synonyms
- DMBA;N-BENZYLDIMETHYLAMINE;dimethylbenzanthracene;DMBZA;7,12-Dimethylbenzanthracene;7,12-DIMETHYLBENZO(A)ANTHRACENE;DMBAn;SKL149;7,12-DMBA;NCI-C03918
- CBNumber
- CB1384824
- Molecular Formula
- C20H16
- Formula Weight
- 256.34
- MOL File
- 57-97-6.mol
7,12-DIMETHYLBENZ[A]ANTHRACENE Property
- Melting point:
- 122-123 °C(lit.)
- Boiling point:
- 183-184 °C765 mm Hg(lit.)
- Density
- 0.9 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.501(lit.)
- Flash point:
- 130 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Crystalline Powder
- color
- Yellow to greenish
- Merck
- 14,3235
- BRN
- 1912135
- CAS DataBase Reference
- 57-97-6(CAS DataBase Reference)
- EPA Substance Registry System
- 7,12-Dimethylbenz[a]anthracene (57-97-6)
Safety
- Hazard Codes
- T
- Risk Statements
- 22-45
- Safety Statements
- 45-53-36/37
- WGK Germany
- 3
- RTECS
- DP4500000
- F
- 10-13-23
- HS Code
- 29029090
- Hazardous Substances Data
- 57-97-6(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- D3254
- Product name
- 7,12-Dimethylbenz[a]anthracene
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $265
- Updated
- 2023/06/20
- Product number
- D3254
- Product name
- 7,12-Dimethylbenz[a]anthracene
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $954
- Updated
- 2023/06/20
- Product number
- D0677
- Product name
- 7,12-Dimethylbenz[a]anthracene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $186
- Updated
- 2024/03/01
- Product number
- D0677
- Product name
- 7,12-Dimethylbenz[a]anthracene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $643
- Updated
- 2024/03/01
- Product number
- D3254
- Product name
- 7,12-Dimethylbenz[a]anthracene
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $70.9
- Updated
- 2023/06/20
7,12-DIMETHYLBENZ[A]ANTHRACENE Chemical Properties,Usage,Production
Description
DBA is a greenish-yellow solid. Polynucleararomatic hydrocarbons (PAHs) are compounds containingmultiple benzene rings and are also called polycyclic aromatic hydrocarbons. Molecular weight= 256.36; Freezing/Melting point= 122℃. Insoluble in water
Chemical Properties
Yellow Powder
Uses
A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction
Uses
7,12-Dimethylbenz[a]anthracene was used:
- to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
- in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
- to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
- to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen
Definition
ChEBI: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Synthesis Reference(s)
The Journal of Organic Chemistry, 36, p. 966, 1971 DOI: 10.1021/jo00806a023
General Description
Yellow to greenish-yellow crystals or a yellow solid. Odorless. Maximum fluorescence at 440 nm. Bluish-violet fluorescence in UV light.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
7,12-DIMETHYLBENZ[A]ANTHRACENE is incompatible with strong oxidizing agents .
Fire Hazard
7,12-DIMETHYLBENZ[A]ANTHRACENE is combustible.
Biochem/physiol Actions
7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.
Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intratracheal routes. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Potential Exposure
Oxidizing agents
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. If thischemical contacts the skin, remove contaminated clothingand wash immediately with soap and water. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with DBA youshould be trained on its proper handling and storage. Storein tightly closed containers in a cool, well-ventilated areaaway from oxidizers. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045.
Shipping
The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21
Purification Methods
Purify DMBA by chromatography on alumina/toluene or *benzene. Crystallise it from acetone/EtOH. [Beilstein 5 IV 2587.]
Incompatibilities
Contact can irritate and burn theskin and eyes. Irritates the respiratory tract. High exposuremay damage the blood cells, causing anemia
7,12-DIMETHYLBENZ[A]ANTHRACENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7,12-DIMETHYLBENZ[A]ANTHRACENE manufacturers
- Product
- DMBA
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2021-02-24
- Product
- 7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
- Price
- US $16.99/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-12-22
- Product
- 7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-14