ChemicalBook > CAS DataBase List > 7,12-DIMETHYLBENZ[A]ANTHRACENE

7,12-DIMETHYLBENZ[A]ANTHRACENE

Product Name
7,12-DIMETHYLBENZ[A]ANTHRACENE
CAS No.
57-97-6
Chemical Name
7,12-DIMETHYLBENZ[A]ANTHRACENE
Synonyms
DMBA;N-BENZYLDIMETHYLAMINE;dimethylbenzanthracene;DMBZA;7,12-Dimethylbenzanthracene;7,12-DIMETHYLBENZO(A)ANTHRACENE;DMBAn;SKL149;7,12-DMBA;NCI-C03918
CBNumber
CB1384824
Molecular Formula
C20H16
Formula Weight
256.34
MOL File
57-97-6.mol
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7,12-DIMETHYLBENZ[A]ANTHRACENE Property

Melting point:
122-123 °C(lit.)
Boiling point:
183-184 °C765 mm Hg(lit.)
Density 
0.9 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.501(lit.)
Flash point:
130 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Powder
color 
Yellow to greenish
Merck 
14,3235
BRN 
1912135
CAS DataBase Reference
57-97-6(CAS DataBase Reference)
EPA Substance Registry System
7,12-Dimethylbenz[a]anthracene (57-97-6)
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Safety

Hazard Codes 
T
Risk Statements 
22-45
Safety Statements 
45-53-36/37
WGK Germany 
3
RTECS 
DP4500000
F 
10-13-23
HS Code 
29029090
Hazardous Substances Data
57-97-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3254
Product name
7,12-Dimethylbenz[a]anthracene
Purity
≥95%
Packaging
1g
Price
$265
Updated
2023/06/20
Sigma-Aldrich
Product number
D3254
Product name
7,12-Dimethylbenz[a]anthracene
Purity
≥95%
Packaging
5g
Price
$954
Updated
2023/06/20
TCI Chemical
Product number
D0677
Product name
7,12-Dimethylbenz[a]anthracene
Purity
>98.0%(GC)
Packaging
1g
Price
$186
Updated
2024/03/01
TCI Chemical
Product number
D0677
Product name
7,12-Dimethylbenz[a]anthracene
Purity
>98.0%(GC)
Packaging
5g
Price
$643
Updated
2024/03/01
Sigma-Aldrich
Product number
D3254
Product name
7,12-Dimethylbenz[a]anthracene
Purity
≥95%
Packaging
100mg
Price
$70.9
Updated
2023/06/20
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7,12-DIMETHYLBENZ[A]ANTHRACENE Chemical Properties,Usage,Production

Description

DBA is a greenish-yellow solid. Polynucleararomatic hydrocarbons (PAHs) are compounds containingmultiple benzene rings and are also called polycyclic aromatic hydrocarbons. Molecular weight= 256.36; Freezing/Melting point= 122℃. Insoluble in water

Chemical Properties

Yellow Powder

Uses

A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction

Uses

7,12-Dimethylbenz[a]anthracene was used:

  • to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
  • in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
  • to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
  • to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen

Definition

ChEBI: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 966, 1971 DOI: 10.1021/jo00806a023

General Description

Yellow to greenish-yellow crystals or a yellow solid. Odorless. Maximum fluorescence at 440 nm. Bluish-violet fluorescence in UV light.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

7,12-DIMETHYLBENZ[A]ANTHRACENE is incompatible with strong oxidizing agents .

Fire Hazard

7,12-DIMETHYLBENZ[A]ANTHRACENE is combustible.

Biochem/physiol Actions

7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intratracheal routes. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Oxidizing agents

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. If thischemical contacts the skin, remove contaminated clothingand wash immediately with soap and water. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with DBA youshould be trained on its proper handling and storage. Storein tightly closed containers in a cool, well-ventilated areaaway from oxidizers. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045.

Shipping

The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21

Purification Methods

Purify DMBA by chromatography on alumina/toluene or *benzene. Crystallise it from acetone/EtOH. [Beilstein 5 IV 2587.]

Incompatibilities

Contact can irritate and burn theskin and eyes. Irritates the respiratory tract. High exposuremay damage the blood cells, causing anemia

7,12-DIMETHYLBENZ[A]ANTHRACENE Preparation Products And Raw materials

Raw materials

Preparation Products

Bifenthrin 2-bromo-N,N-dimethylbenzylamine
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7,12-DIMETHYLBENZ[A]ANTHRACENE Suppliers

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View Lastest Price from 7,12-DIMETHYLBENZ[A]ANTHRACENE manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
DMBA
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-02-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
Price
US $16.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-12-22
Career Henan Chemical Co
Product
7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-14

57-97-6, 7,12-DIMETHYLBENZ[A]ANTHRACENERelated Search:

7,12-DIMETHYLBENZ[A]ANTHRACENE DL-DOPA Phenanthrene 1,2-BENZANTHRACENE 7-hydroxymethyl-12-methylbenz(a)anthracene 3-bromo-7,12-dimethylbenz(a)anthracene 7-chloromethyl-12-methylbenz(a)anthracene BENZ[A]ANTHRACENE-7,12-DICARBOXALDEHYDE 7,12-DIMETHYLBENZ(A)ANTHRACENE-3,4-DIOL 3-hydroxy-7,12-dimethylbenz(a)anthracene 7-ETHYL-12-METHYLBENZ(A)ANTHRACENE 7,8,12-trimethylbenz(a)anthracene 7,12-Dimethylbenz[a]anthracene-3,9-diol=diacetate 4-methoxy-7,12-dimethylbenz(a)anthracene 2-methoxy-7,12-dimethylbenz(a)anthracene 7,12-dihydroxymethylbenz(a)anthracene 12-hydroxymethyl-7-methylbenz(a)anthracene 4-bromo-7,12-dimethylbenz(a)anthracene

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  • 7,12-diMethyltetraphene
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  • NCI-C03918
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  • 7.12-Dimethylbenz(a)anthracene 100mg [57-97-6]
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  • 7,12-Dimethylbenz[a]anthreceneSolution,2,000mg/L,1ml
  • 7,12-Dimethylbenz(a)anthracene@1000 μg/mL in CH2Cl2