7,12-DIMETHYLBENZ[A]ANTHRACENE

ChemicalBook > CAS DataBase List > 7,12-DIMETHYLBENZ[A]ANTHRACENE

7,12-DIMETHYLBENZ[A]ANTHRACENE

Product Name: 7,12-DIMETHYLBENZ[A]ANTHRACENE
CAS No.: 57-97-6
Chemical Name: 7,12-DIMETHYLBENZ[A]ANTHRACENE
Synonyms: DMBA;N-BENZYLDIMETHYLAMINE;dimethylbenzanthracene;DMBZA;7,12-Dimethylbenzanthracene;7,12-DIMETHYLBENZO(A)ANTHRACENE;DMBAn;SKL149;7,12-DMBA;NCI-C03918
CBNumber: CB1384824
Molecular Formula: C20H16
Formula Weight: 256.34
MOL File: 57-97-6.mol

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7,12-DIMETHYLBENZ[A]ANTHRACENE Property

Melting point:: 122-123 °C(lit.)
Boiling point:: 183-184 °C765 mm Hg(lit.)
Density: 0.9 g/mL at 25 °C(lit.)
refractive index: n20/D 1.501(lit.)
Flash point:: 130 °F
storage temp.: Sealed in dry,Room Temperature
form: Crystalline Powder
color: Yellow to greenish
Merck: 14,3235
BRN: 1912135
CAS DataBase Reference: 57-97-6(CAS DataBase Reference)
EPA Substance Registry System: 7,12-Dimethylbenz[a]anthracene (57-97-6)

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Safety

Hazard Codes: T
Risk Statements: 22-45
Safety Statements: 45-53-36/37
WGK Germany: 3
RTECS: DP4500000
F: 10-13-23
HS Code: 29029090
Hazardous Substances Data: 57-97-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3254
Product name: 7,12-Dimethylbenz[a]anthracene
Purity: ≥95%
Packaging: 1g
Price: $265
Updated: 2023/06/20

Sigma-Aldrich

Product number: D3254
Product name: 7,12-Dimethylbenz[a]anthracene
Purity: ≥95%
Packaging: 5g
Price: $954
Updated: 2023/06/20

TCI Chemical

Product number: D0677
Product name: 7,12-Dimethylbenz[a]anthracene
Purity: >98.0%(GC)
Packaging: 1g
Price: $186
Updated: 2024/03/01

TCI Chemical

Product number: D0677
Product name: 7,12-Dimethylbenz[a]anthracene
Purity: >98.0%(GC)
Packaging: 5g
Price: $643
Updated: 2024/03/01

Sigma-Aldrich

Product number: D3254
Product name: 7,12-Dimethylbenz[a]anthracene
Purity: ≥95%
Packaging: 100mg
Price: $70.9
Updated: 2023/06/20

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7,12-DIMETHYLBENZ[A]ANTHRACENE Chemical Properties,Usage,Production

Description

DBA is a greenish-yellow solid. Polynucleararomatic hydrocarbons (PAHs) are compounds containingmultiple benzene rings and are also called polycyclic aromatic hydrocarbons. Molecular weight= 256.36; Freezing/Melting point= 122℃. Insoluble in water

Chemical Properties

Yellow Powder

Uses

A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction

Uses

7,12-Dimethylbenz[a]anthracene was used:

to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12^doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen

Definition

ChEBI: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 966, 1971 DOI: 10.1021/jo00806a023

General Description

Yellow to greenish-yellow crystals or a yellow solid. Odorless. Maximum fluorescence at 440 nm. Bluish-violet fluorescence in UV light.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

7,12-DIMETHYLBENZ[A]ANTHRACENE is incompatible with strong oxidizing agents .

Fire Hazard

7,12-DIMETHYLBENZ[A]ANTHRACENE is combustible.

Biochem/physiol Actions

7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intratracheal routes. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Oxidizing agents

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. If thischemical contacts the skin, remove contaminated clothingand wash immediately with soap and water. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with DBA youshould be trained on its proper handling and storage. Storein tightly closed containers in a cool, well-ventilated areaaway from oxidizers. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045.

Shipping

The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21

Purification Methods

Purify DMBA by chromatography on alumina/toluene or *benzene. Crystallise it from acetone/EtOH. [Beilstein 5 IV 2587.]

Incompatibilities

Contact can irritate and burn theskin and eyes. Irritates the respiratory tract. High exposuremay damage the blood cells, causing anemia

7,12-DIMETHYLBENZ[A]ANTHRACENE Preparation Products And Raw materials

Raw materials

Preparation Products

Bifenthrin 2-bromo-N,N-dimethylbenzylamine

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View Lastest Price from 7,12-DIMETHYLBENZ[A]ANTHRACENE manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: DMBA
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2021-02-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
Price: US $16.99/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2021-12-22

Career Henan Chemical Co

Product: 7,12-DIMETHYLBENZ[A]ANTHRACENE 57-97-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-14

57-97-6, 7,12-DIMETHYLBENZ[A]ANTHRACENERelated Search:

N-BENZYLDIMETHYLAMINE

N-BENZYL-N, N-DIMETHYLAMINE

N,N-DIMETHYLBENZENEMETHANAMINE

N,N-BENZYLDIMETHYLAMINE

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7,12-Dimethylbenzanthracene

7,12-dimethylbenzanthrancene

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9,10-dimethyl-benzanthracene

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dimethylbenz(a)anthracene

Dimethylbenz[a]anthracene

dimethylbenzanthracene

7,12-diMethyltetraphene

7,12-Dimethylbenz[a]anthracene, 98.5%

NCI-C03918

rcrawastenumberu094

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