4,6-DIOXOHEPTANOIC ACID
- Product Name
- 4,6-DIOXOHEPTANOIC ACID
- CAS No.
- 51568-18-4
- Chemical Name
- 4,6-DIOXOHEPTANOIC ACID
- Synonyms
- SUCCINYLACETONE;4,6-dioxoheptanoicaci;[13C7]-Succinylacetone;4,6-DIOXOHEPTANOIC ACID;Succinylacetone in Water;Heptanoic acid, 4,6-dioxo-;Succinylacetone-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid (mixture of isomers)
- CBNumber
- CB1385063
- Molecular Formula
- C7H10O4
- Formula Weight
- 158.15
- MOL File
- 51568-18-4.mol
4,6-DIOXOHEPTANOIC ACID Property
- Melting point:
- 66-67 °C(lit.)
- Boiling point:
- 318.7±17.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 4.54±0.17(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 51568-18-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D1415
- Product name
- 4,6-Dioxoheptanoic acid
- Purity
- powder
- Packaging
- 100mg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- D1415
- Product name
- 4,6-Dioxoheptanoic acid
- Purity
- powder
- Packaging
- 1g
- Price
- $1790
- Updated
- 2024/03/01
- Product number
- U0127
- Product name
- Succinylacetone
- Packaging
- 100MG
- Price
- $234
- Updated
- 2023/01/07
- Product number
- U0127
- Product name
- Succinylacetone
- Packaging
- 25MG
- Price
- $79
- Updated
- 2022/04/27
- Product number
- 25501
- Product name
- Succinylacetone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
4,6-DIOXOHEPTANOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
4,6-Dioxoheptanoic acid has been used:
- as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
- as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
- as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)
Uses
Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope quid urine using a 13C4-SA as internal standard.
Definition
ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Biochem/physiol Actions
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.
4,6-DIOXOHEPTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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