ChemicalBook > CAS DataBase List > 4,6-DIOXOHEPTANOIC ACID

4,6-DIOXOHEPTANOIC ACID

Product Name
4,6-DIOXOHEPTANOIC ACID
CAS No.
51568-18-4
Chemical Name
4,6-DIOXOHEPTANOIC ACID
Synonyms
SUCCINYLACETONE;4,6-dioxoheptanoicaci;[13C7]-Succinylacetone;4,6-DIOXOHEPTANOIC ACID;Succinylacetone in Water;Heptanoic acid, 4,6-dioxo-;Succinylacetone-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid (mixture of isomers)
CBNumber
CB1385063
Molecular Formula
C7H10O4
Formula Weight
158.15
MOL File
51568-18-4.mol
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4,6-DIOXOHEPTANOIC ACID Property

Melting point:
66-67 °C(lit.)
Boiling point:
318.7±17.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
4.54±0.17(Predicted)
color 
White to Off-White
CAS DataBase Reference
51568-18-4
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1415
Product name
4,6-Dioxoheptanoic acid
Purity
powder
Packaging
100mg
Price
$313
Updated
2024/03/01
Sigma-Aldrich
Product number
D1415
Product name
4,6-Dioxoheptanoic acid
Purity
powder
Packaging
1g
Price
$1790
Updated
2024/03/01
TCI Chemical
Product number
U0127
Product name
Succinylacetone
Packaging
100MG
Price
$234
Updated
2023/01/07
TCI Chemical
Product number
U0127
Product name
Succinylacetone
Packaging
25MG
Price
$79
Updated
2022/04/27
Cayman Chemical
Product number
25501
Product name
Succinylacetone
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
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4,6-DIOXOHEPTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

4,6-Dioxoheptanoic acid has been used:

  • as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
  • as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
  • as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)

Uses

Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope quid urine using a 13C4-SA as internal standard.

Definition

ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.

Biochem/physiol Actions

4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.

4,6-DIOXOHEPTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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51568-18-4, 4,6-DIOXOHEPTANOIC ACIDRelated Search:

Heptanoic acid prohexadione-calcium 4,6-DIOXOHEPTANOIC ACID 3,5-Dioxocyclohexanecarboxylic acid TRINEXAPAC-ETHYL Trinexapac-ethyl PROHEXADIONE 4-ACETYL-3,5-DIOXO-1-METHYLCYCLOHEXANECARBOXYLIC ACID Ethyl 2,4-dioxoheptanoate ,97% 4-ACETYL-3,5-DIOXO-CHA(1-ME, 1-COOH) 3,5-DIOXO-4-PROPIONYL-CYCLOHEXANECARBOXYLIC ACID CALCIUM SALT 7-(4-Methoxyphenyl)-5,7-dioxoheptanoic acid 7-(4-Chlorophenyl)-5,7-dioxoheptanoic acid 2-Diazo-3,6-dioxoheptanoic acid ethyl ester 7-(4-CHLOROPHENYL)-4,7-DIOXOHEPTANOIC ACID 7-(5-METHYLTHIEN-2-YL)-4,7-DIOXOHEPTANOIC ACID BIS-2,2-SUCCINOYLMETHYLENE-PROPIONIC ACID CHOLESTERYL ESTER 3-(1,2,3,4-Tetrahydro-6-methoxy-1-oxo-2-naphthoyl)propionicacid

  • 4,6-DIOXOHEPTANOIC ACID
  • SUCCINYLACETONE
  • Succinylacetone-3,4,5,6,7-13C5
  • 4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5
  • [13C7]-Succinylacetone
  • Heptanoic acid, 4,6-dioxo-
  • 4,6-dioxoheptanoicaci
  • 4,6-Dioxoheptanoic acid (mixture of isomers)
  • Succinylacetone in Water
  • 51568-18-4
  • CH3COCH2COCH2CH2CO2H
  • Biochemicals and Reagents
  • BioChemical
  • Saturated fatty acids and derivatives
  • Lipids
  • Keto fatty acids
  • Fatty Acids
  • Aliphatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals