ChemicalBook > CAS DataBase List > 3',4',5,7-TETRAHYDROXYISOFLAVONE

3',4',5,7-TETRAHYDROXYISOFLAVONE

Product Name
3',4',5,7-TETRAHYDROXYISOFLAVONE
CAS No.
480-23-9
Chemical Name
3',4',5,7-TETRAHYDROXYISOFLAVONE
Synonyms
Orbol;Orobo;OROBOL;isoluteolin;3'-Hydroxygenistein;5,7,3’,4’-tetrahydroxyisoflavone;3’,4’,5,7-tetrahydroxy-isoflavon;3',4',5,7-TETRAHYDROXYISOFLAVONE;3',4',5,7-Tetrahydroxyisoflavone Orobol;3'-Hydroxygenistein|||3’,4’,5,7-tetrahydroxy-isoflavon
CBNumber
CB1391240
Molecular Formula
C15H10O6
Formula Weight
286.24
MOL File
480-23-9.mol
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3',4',5,7-TETRAHYDROXYISOFLAVONE Property

Melting point:
270 °C
Boiling point:
616.1±55.0 °C(Predicted)
Density 
1.654±0.06 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
6.37±0.20(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FO137892
Product name
Orobol
Packaging
500ug
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO137892
Product name
Orobol
Packaging
1mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO137892
Product name
Orobol
Packaging
2mg
Price
$280
Updated
2021/12/16
AK Scientific
Product number
W1721
Product name
Orobol
Packaging
1mg
Price
$286
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000208
Product name
3',4',5,7-TETRAHYDROXY ISOFLAVONE
Purity
95.00%
Packaging
5MG
Price
$500.58
Updated
2021/12/16
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3',4',5,7-TETRAHYDROXYISOFLAVONE Chemical Properties,Usage,Production

Uses

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ)[1][2].

Definition

ChEBI: Orobol is a member of the class of 7-hydroxyisoflavones which consists of isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4'. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as an anti-inflammatory agent, a radical scavenger, a plant metabolite and a fungal metabolite. It is functionally related to an isoflavone.

in vivo

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice[2].

Animal Model:HFD-induced obesity in C57BL/6J mice[2]
Dosage:10?mg/kg
Administration:Intragastrically; daily for 23 weeks
Result:Significantly reduced body weight by 17.3% compared to the HFD group.

target

PI3K | Caspase | Bcl-2/Bax | Calcium Channel | Antifection | Influenza virus

References

[1] Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12(9):845. Published 2020 Sep 3. DOI:10.3390/pharmaceutics12090845

3',4',5,7-TETRAHYDROXYISOFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4',5,7-TETRAHYDROXYISOFLAVONE Suppliers

China 74 India 1 United Kingdom 5 United States 4 Global 84
Carbosynth
Tel
--
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apin Chemicals Limited (UK)
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info@apinchemicals.com
Country
United Kingdom
ProdList
6184
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60
Eurolabs Limited
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Country
United Kingdom
ProdList
6309
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46
Sequoia Research Products Ltd.
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Fax
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Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
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Apin Chemicals Ltd.
Tel
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Fax
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Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
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View Lastest Price from 3',4',5,7-TETRAHYDROXYISOFLAVONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Orobol 480-23-9
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-09

480-23-9, 3',4',5,7-TETRAHYDROXYISOFLAVONERelated Search:

LUTEOLIN-3',7-DI-O-GLUCOSIDE 5-HYDROXYDEQUELIN 5,7,3',4'-TETRAMETHOXYISOFLAVONE 3'-O-METHYLPRATENSEIN OROBOL 7,4'-DIMETHYL ETHER OROBOL 7,3',4'-TRIMETHYL ETHER PRATENSEIN 3',4',5,7-TETRAHYDROXYISOFLAVONE ISOPOMIFERIN 6'-METHOXY-2'-PRENYL-5,7,3',4'-TETRAHYDROXYISOFLAVONE 5,7-DIHYDROXY-3',4'-METHYLENEDIOXYISOFLAVONE 5-METHOXYDURMILLONE POMIFERIN OROBOL 7,3'-DIMETHYL ETHER 7-METHOXY-3',4',5-TRIHYDROXYISOFLAVONE ISOPOMIFERIN-3',4'-DIMETHYL ETHER 5-METHOXYMETHYLACICERONE OROBOL-3'-METHYL ETHER

  • OROBOL
  • 3’,4’,5,7-tetrahydroxy-isoflavon
  • 5,7,3’,4’-tetrahydroxyisoflavone
  • 5,7-dihydroxy-3-(3,4-dihydroxyphenyl)-4h-1-benzopyran-4-on
  • 5,7-dihydroxy-3-(3,4-dihydroxyphenyl)-4h-1-benzopyran-4-one
  • isoluteolin
  • 3-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 3'-Hydroxygenistein
  • 3',4',5,7-TETRAHYDROXYISOFLAVONE
  • 3',4',5,7-Tetrahydroxyisoflavone Orobol
  • 4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
  • Orbol
  • Orobo
  • 3'-Hydroxygenistein|||3’,4’,5,7-tetrahydroxy-isoflavon
  • 480-23-9
  • Iso-Flavones